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Paf-acether (Platelet-activating Factor)
1986Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine was unveiled in 1979, it was thus named “Paf-acether”, given the ether linkage at position 1 and the acetyl group at position 2 of glycerol. Paf-
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2016
Platelet-activating factor (PAF) is a phospholipid produced by a variety of cells including platelets, endothelial cells, neutrophils, monocytes and macrophages. It has a wide range of potent biological activities including wound healing, physiological inflammation, apoptosis, angiogenesis, reproduction and long-term potentiation.
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Platelet-activating factor (PAF) is a phospholipid produced by a variety of cells including platelets, endothelial cells, neutrophils, monocytes and macrophages. It has a wide range of potent biological activities including wound healing, physiological inflammation, apoptosis, angiogenesis, reproduction and long-term potentiation.
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2000
Research leading to the discovery of platelet-activating factor (PAF) came from studying a reaction that triggered platelets to release histamine. It was attributed to a factor actively released from leukocytes. Platelet-activating factor was first identified by Benveniste et al. in 1972.1 Later it was recognized that this phospholipid mediator is also
M. Poeze +3 more
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Research leading to the discovery of platelet-activating factor (PAF) came from studying a reaction that triggered platelets to release histamine. It was attributed to a factor actively released from leukocytes. Platelet-activating factor was first identified by Benveniste et al. in 1972.1 Later it was recognized that this phospholipid mediator is also
M. Poeze +3 more
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Platelet Activating Factor and Platelets
1999Among agents which activate platelets PAF is unique since it is the only phospholipid known to date which stimulates platelets at nanomolar range. The first indications of such a mediator dates back to 1966 when it was observed that a mixture of rabbit platelets and stimulated leukocytes released histamine on specific antigen challenge (Barbaro and ...
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1995
Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
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Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
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Platelet-activating factor receptor
Journal of Lipid Mediators and Cell Signalling, 1995T, Izumi +6 more
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