Results 241 to 250 of about 1,166,887 (302)

Platelet-Activating Factor and Angiogenesis

1996
Platelet-activating factor (PAF) is a phospholipid autacoid with a spectrum of diverse and potent biological properties relevant for the development of inflammatory reaction and septic shock1. Recently, PAF has been also implicated in the embryogenesis and cell differentiation2,3. Researchers believe that PAF is a mediator of cell to cell communication
G, Camussi, G, Montrucchio, E, Lupia, M, Arese, F, Bussolino   +4 more
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Desensitization of human platelets by platelet activating factor

Biochemical and Biophysical Research Communications, 1985
Human platelets are less responsive to PAF at 37 degrees than at 25 degrees. They can be desensitized to the effects of PAF by pre-exposure to small concentrations. In both cases desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF rather than loss of binding sites.
C M, Chesney, D D, Pifer, K M, Huch
openaire   +2 more sources

Platelet Activating Factor Receptors

2003
Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
A Marilise, Marrache, Fernand, Gobeil, Sylvie G, Bernier, Jana, Stankova, Marek, Rola-Pleszczynski, Sanaa, Choufani, Ghassan, Bkaily, Annie, Bourdeau, Martin G, Sirois, Alejandro, Vazquez-Tello, L, Fan, Jean-Sebastien, Joyal, Janos G, Filep, Daya R, Varma, Alfredo, Ribeiro-Da-silva, Sylvain, Chemtob   +15 more
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Platelet Factor 3 Activity in Washed Platelets

Thrombosis and Haemostasis, 1973
SummaryPlatelets collected with an EDTA solution and simply washed in an incomplete Tyrode’s presented clotting times in the recalcification (man and rat) and the Stypven (rat) tests that were practically identical to those of the PRP when slow speed centrifugation was used (800 G in man, 1000 G in rat). This was demonstrated, in 6 pools of 5 rats each
S, Renaud, P, Gautheron, H, Rosenstein
openaire   +2 more sources

Platelet Microparticles: A Carrier of Platelet-Activating Factor?

Biochemical and Biophysical Research Communications, 1996
Platelet-activating factor (PAF) has been considered to be released in a soluble form from activated platelets. Also a considerable number of microparticles were released from stimulated platelets. To evaluate the possibility that microparticles contain PAF, the amount of PAF in whole activated platelets, microparticles and the suspending medium was ...
S, Iwamoto, T, Kawasaki, J, Kambayashi, H, Ariyoshi, M, Monden   +4 more
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Platelet-activating factor acetylhydrolase

Prostaglandins & Other Lipid Mediators, 2002
Platelet-activating factor (PAF) is one of the most potent lipid mediators and is involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is required for its biological activity, and deacetylation of PAF induces loss of activity. The deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH)
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Platelet-Activating Factor

Reference Module in Biomedical Sciences, 2021
K. Chung
semanticscholar   +1 more source

Platelet Activating Factor and Platelets

1999
Among agents which activate platelets PAF is unique since it is the only phospholipid known to date which stimulates platelets at nanomolar range. The first indications of such a mediator dates back to 1966 when it was observed that a mixture of rabbit platelets and stimulated leukocytes released histamine on specific antigen challenge (Barbaro and ...
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Pathobiology of Platelet-Activating Factors

Pathology and Immunopathology Research, 2008
Throughout the evolution of knowledge about inflammation, a primary goal has been to understand this important biological response in sufficient depth to prevent the unwanted tissue injury that may spontaneously occur or that may coevolve to produce disease.
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Role for Platelet-Activating Factor in Asthma

Lipids, 1991
AbstractRecent studies of the effects of platelet‐activating factor (PAF) on huan and animal airways would support a putative role for this lipid mediator in asthma. PAF can induce many aspects of the clinical and pathological features seen in asthmatic airways such as airway oedema, eosinophil accumulation in the airway wall, and bronchial ...
K F, Chung, P J, Barnes
openaire   +2 more sources