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Cardiovascular Effects of Platelet-Activating Factor
Lipids, 1991AbstractSudden release of platelet‐activating factor (PAF) into the circulation can cause hypotension, tachycardia, and circulatory collapse. To further examine this response, we performed detailed studies of cardiovascular function after PAF administration to young domestic pigs and newborn piglets.
R E, Goldstein +5 more
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Synthesis of platelet-activating factor by human monocytes stimulated by platelet-activating factor
Journal of Allergy and Clinical Immunology, 1991The capacity of platelet-activating factor (PAF) to stimulate its own synthesis by human monocytes was examined. Adherent human monocytes of greater than 85% purity were incubated with 100 fM to 10 nM of PAF in the presence of 20 microCi of [3H]acetic acid to radiolabel newly synthesized PAF.
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Structural basis for signal recognition and transduction by platelet-activating-factor receptor
Nature Structural & Molecular Biology, 2018C. Cao +21 more
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Perspectives in platelet-activating factor research.
Pharmacological Reviews, 1987P. Braquet +3 more
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Paf-acether (Platelet-activating Factor)
1986Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine was unveiled in 1979, it was thus named “Paf-acether”, given the ether linkage at position 1 and the acetyl group at position 2 of glycerol. Paf-
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Structural analysis of purified platelet-activating factor by lipases
Nature, 1977J. Benveniste +3 more
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