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Platelet-activating factor acetylhydrolase
Prostaglandins & Other Lipid Mediators, 2002Platelet-activating factor (PAF) is one of the most potent lipid mediators and is involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is required for its biological activity, and deacetylation of PAF induces loss of activity. The deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH)
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Platelet Activating Factor and Platelets
1999Among agents which activate platelets PAF is unique since it is the only phospholipid known to date which stimulates platelets at nanomolar range. The first indications of such a mediator dates back to 1966 when it was observed that a mixture of rabbit platelets and stimulated leukocytes released histamine on specific antigen challenge (Barbaro and ...
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Pathobiology of Platelet-Activating Factors
Pathology and Immunopathology Research, 2008Throughout the evolution of knowledge about inflammation, a primary goal has been to understand this important biological response in sufficient depth to prevent the unwanted tissue injury that may spontaneously occur or that may coevolve to produce disease.
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Role for Platelet-Activating Factor in Asthma
Lipids, 1991AbstractRecent studies of the effects of platelet‐activating factor (PAF) on huan and animal airways would support a putative role for this lipid mediator in asthma. PAF can induce many aspects of the clinical and pathological features seen in asthmatic airways such as airway oedema, eosinophil accumulation in the airway wall, and bronchial ...
K F, Chung, P J, Barnes
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Cardiovascular Effects of Platelet-Activating Factor
Lipids, 1991AbstractSudden release of platelet‐activating factor (PAF) into the circulation can cause hypotension, tachycardia, and circulatory collapse. To further examine this response, we performed detailed studies of cardiovascular function after PAF administration to young domestic pigs and newborn piglets.
R E, Goldstein +5 more
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Synthesis of platelet-activating factor by human monocytes stimulated by platelet-activating factor
Journal of Allergy and Clinical Immunology, 1991The capacity of platelet-activating factor (PAF) to stimulate its own synthesis by human monocytes was examined. Adherent human monocytes of greater than 85% purity were incubated with 100 fM to 10 nM of PAF in the presence of 20 microCi of [3H]acetic acid to radiolabel newly synthesized PAF.
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2000
Research leading to the discovery of platelet-activating factor (PAF) came from studying a reaction that triggered platelets to release histamine. It was attributed to a factor actively released from leukocytes. Platelet-activating factor was first identified by Benveniste et al. in 1972.1 Later it was recognized that this phospholipid mediator is also
M. Poeze +3 more
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Research leading to the discovery of platelet-activating factor (PAF) came from studying a reaction that triggered platelets to release histamine. It was attributed to a factor actively released from leukocytes. Platelet-activating factor was first identified by Benveniste et al. in 1972.1 Later it was recognized that this phospholipid mediator is also
M. Poeze +3 more
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Paf-acether (Platelet-activating Factor)
1986Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine was unveiled in 1979, it was thus named “Paf-acether”, given the ether linkage at position 1 and the acetyl group at position 2 of glycerol. Paf-
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