No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan‐induced inhibition of platelet aggregation response [PDF]
Journal of Veterinary Internal Medicine, 2023 Background A variant in the canine phosphodiesterase (PDE) 5A gene (PDE5A:E90K) is associated with decreased concentrations of circulating cyclic guanosine monophosphate (cGMP) and response to PDE5 inhibitor treatment.
Maria J. Reimann +9 more
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The Ratio of ADP- to TRAP-Induced Platelet Aggregation Quantifies P2Y12-Dependent Platelet Inhibition Independently of the Platelet Count. [PDF]
PLoS ONE, 2016 This study aimed to assess the association of clinical factors with P2Y12-dependent platelet inhibition as monitored by the ratio of ADP- to TRAP-induced platelet aggregation and conventional ADP-induced aggregation, respectively.Controversial findings ...
Christoph B Olivier +8 more
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Correlation Between P-Selectin Level and Platelet Aggregation in Cerebral Venous Sinus Thrombosis Patients [PDF]
Majalah Kedokteran Bandung, 2023 One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level.
Rahmawati Nurmin +4 more
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Effect of 3-Day Storage and Temperature on ADP-induced Platelet Aggregation [PDF]
International Journal of Integrated Health Sciences, 2018 Objective: To observe platelet functions during the 3 days of platelet storage and to evaluate the effect of storage temperature towards platelet aggregation response.
Nanda Ayu Puspita, Suryawati
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An investigation of the antiplatelet effects of succinobucol (AGI-1067) [PDF]
Platelets, 2017 Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Given the importance of oxidant stress in modulating platelet–platelet and platelet–vessel wall interactions, the aim of this study was to establish if antioxidant ...
Stephanie A. Houston +3 more
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Mucor circinelloides induces platelet aggregation through integrin αIIbβ3 and FcγRIIA [PDF]
Platelets, 2019 Thrombosis is a hallmark of the fatal fungal infection mucormycosis. Yet, the platelet activation pathway in response to mucormycetes is unknown. In this study we determined the platelet aggregation potential of Mucor circinelloides (M.
Harlene Ghuman +5 more
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Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood [PDF]
Frontiers in Immunology, 2022 IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem +14 more
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Physiological platelet aggregation assay to mitigate drug-induced thrombocytopenia using a microphysiological system [PDF]
Scientific ReportsDeveloping a reliable method to predict thrombocytopenia is imperative in drug discovery. Here, we establish an assay using a microphysiological system (MPS) to recapitulate the in-vivo mechanisms of platelet aggregation and adhesion.
Kosuke Harada +2 more
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Macrostachyols A-D, oligostilbenes from Gnetum macrostachyum inhibited in vitro human platelet aggregation [PDF]
Journal of HerbMed Pharmacology, 2021 Introduction: Gnetum macrostachyum is a known Thai medicinal plant as a source of bioactive oligostilbenes, which possess platelet inhibitory activities.
Serm Surapinit, Nuttakorn Baisaeng
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Ex vivo STUDY OF THE ACTION OF INTEGRIN RECEPTORS ANTAGONIST FROM ECHIS MULTISQUAMATIS SNAKE VENOM ON PLATELETS OF PREGNANT WOMEN WITH COMPICATIONS DURING GESTATION [PDF]
Biotechnologia Acta, 2023 Aim. In our work, we studied platelet aggregation in blood plasma of pregnant women and estimated the possibility of ex vivo normalization of aggregation rate using a polypeptide from the Echis multisquamatus snake venom.
O. M. PLATONOV, I. V. US
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