Platelet aggregation pathway [PDF]
Pharmacogenetics and Genomics, 2011 Platelet activation and coagulation normally do not occur in an intact blood vessel. After blood vessel wall injury, platelet plug formation is initiated by the adherence of the platelets to subendothelial collagen [1,2]. In high shear arterial blood, platelets are first slowed down from their blood flow velocity by interacting with the collagen-bound ...
Russ B. Altman +3 more
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Early recovery of microvascular perfusion induced by t-PA in combination with abciximab or eptifibatide during postischemic reperfusion [PDF]
, 2002 BACKGROUND: GPIIb/IIIa inhibitors abciximab and eptifibatide have been shown to inhibit platelet aggregation in ischemic heart disease. Our aim was to test the efficacy of abiciximab (Reo Pro) or eptifibatide (Integrilin) alone or in combination with ...
Bertuglia, Silva, Giusti, Andrea
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PLATELET PHAGOCYTOSIS AND AGGREGATION [PDF]
The Journal of Cell Biology, 1965 The addition of latex particles to native (no anticoagulant) or citrated human platelet-rich plasma (PRP), or to a once-washed platelet suspension causes platelet aggregation. This aggregation is associated with phagocytosis of the latex particles by the platelets and appears to be due to release of adenosine diphosphate (ADP) from the platelets ...
James F. Mustard +3 more
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Adiponectin diminishes platelet aggregation and sCD40L release. Potential role in the metabolic syndrome [PDF]
, 2010 The proinflammatory and proatherogenic mediator, soluble CD40 ligand (CD40L), is increased in the metabolic syndrome (MS) and released from platelets. We hypothesized that adiponectin modulates platelet function, and we sought to evaluate the association
Colina, I. (Inmaculada) +3 more
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Polyamines and platelet aggregation
Life Sciences, 1976 Abstract High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents.
Division of Genetics, Endocrinology and Metabolism Departments of Pediatrics, Biochemistry and Neuroscience University of Florida, Gainesville-Sunland Research Laboratory Gainesville, Florida 32610, U.S.A. ( host institution ) +4 more
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Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 [PDF]
, 2016 Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human ...
Arman, Mònica +5 more
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The glycoprotein IIb/IIIa antagonist c7E3 inhibits platelet aggregation in the presence of heparin-associated antibodies [PDF]
, 1997 Purpose: Heparin-associated antibodies (HAAb), in the presence of heparin, can cause platelet activation and aggregation. The purpose of this study was to assess whether a platelet glycoprotein (GP) IIb/IIIa receptor antagonist, c7E3, would inhibit ...
Liem, Timothy K. +3 more
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Mechanisms Underlying the Morning Increase in Platelet Aggregation: A Flow Cytometry Study [PDF]
, 1996 ObjectivesMechanisms underlying the morning increase in platelet aggregation produced by arising and assuming the upright posture were studied by examining 1) the expression on the platelet surface of activation-dependent markers; 2) platelet aggregation
Andrews, Neil P. +4 more
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FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation [PDF]
, 2005 The bacterium Streptococcus agalactiae is an etiologic agent in the pathogenesis of endocarditis in humans. FbsA, a fibrinogen-binding protein produced by this pathogen, is considered an important virulence factor.
Fitzgerald, J Ross +7 more
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Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
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