Results 41 to 50 of about 123,010 (259)

The Influence of Haemoglobin A1c Levels on Platelet Aggregation and Platelet Turnover in Patients with Coronary Artery Disease Treated with Aspirin. [PDF]

PLoS ONE, 2015
Hyperglycaemia may attenuate the antiplatelet effect of aspirin and thereby increase the risk of cardiovascular events. We investigated the influence of increased haemoglobin A1c (HbA1c) levels on platelet aggregation and turnover in a large cohort of ...
Søs Neergaard-Petersen, Anne-Mette Hvas, Erik Lerkevang Grove, Sanne Bøjet Larsen, Søren Gregersen, Steen Dalby Kristensen   +5 more
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

Adiponectin diminishes platelet aggregation and sCD40L release. Potential role in the metabolic syndrome [PDF]

, 2010
The proinflammatory and proatherogenic mediator, soluble CD40 ligand (CD40L), is increased in the metabolic syndrome (MS) and released from platelets. We hypothesized that adiponectin modulates platelet function, and we sought to evaluate the association
Colina, I. (Inmaculada), Restituto, P. (Patricia), Varo, J.J. (José Javier), Varo-Cenarruzabeitia, M.N. (Miren Nerea)   +3 more
core   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

THE EFFECTIVENESS OF PAPAYA LEAF EXTRACT (CARICA PAPAYA L.) AS AN ANTIAGGREGATION AGENT ON PLATELET COUNT AND PLATELET AGGREGATION: IN VITRO STUDY

Journal of Vocational Health Studies
Background: In hypertensive patients, platelet hyperaggregation may lead to acute ischemic stroke, which can increase mortality or neurological deficits.
Ganjar Noviar, Eem Hayati, Riski Nur Ramadhani   +2 more
doaj   +1 more source

rLOAD: does sex mediate the effect of acute antiplatelet loading on stroke outcome. [PDF]

, 2014
BackgroundBiologic sex can influence response to pharmacologic therapy. The purpose of this proof-of-concept study was to evaluate the medicating effects of estrogen in the efficacy of acute antiplatelet loading therapy on stroke outcome in the rabbit ...
Compton, M Peggy, Eastwood, Jo-Ann, Gylys, Karen, Meyer, Dawn M, Zivin, Justin A   +4 more
core   +3 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

TLR7, TLR9, MyD88, and NF-κB role on platelet aggregation in Yucatecan patients with type 2 diabetes

Revista de la Alad. Asociación Latinoamericana de Diabetes, 2022
Objective: To analyze the expression of TLR7, TLR9, and signaling proteins MyD88 and NF-κB, and their relationship with platelet aggregation in Yucatecan patients with type 2 diabetes.
Lucía G. González-Espinosa, Irma G. Quintal-Ortiz, Yumi E. Nakazawa-Ueji, Juan D. Villarreal-Ku, Ligia G. Alonso-Salomón, Isaac A. López-Briceño, Nina Valadez-González, Guillermo Valencia-Pacheco   +7 more
doaj   +1 more source