Results 41 to 50 of about 119,640 (264)

An investigation of the antiplatelet effects of succinobucol (AGI-1067)

Platelets, 2017
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Given the importance of oxidant stress in modulating platelet–platelet and platelet–vessel wall interactions, the aim of this study was to establish if antioxidant ...
Stephanie A. Houston, Azizah Ugusman, Sukanya Gnanadesikan, Simon Kennedy   +3 more
doaj   +1 more source

Effect of Oral Anti-platelet Regimens on Platelet Aggregation using Chronolog Light Transmittance Aggregometry in Coronary Heart Disease Patients: An Observational Study [PDF]

Journal of Clinical and Diagnostic Research, 2013
Introduction: Coronary heart disease is one of the most common cardiac health problem in India. Anti-platelet therapy is the cornerstone in the management of coronary heart disease.
Kishan P.V., Uday Kumar C., Shobha J.C., Usharani P., Chandrasekhar E.   +4 more
doaj   +1 more source

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

PLATELET PHAGOCYTOSIS AND AGGREGATION [PDF]

The Journal of Cell Biology, 1965
The addition of latex particles to native (no anticoagulant) or citrated human platelet-rich plasma (PRP), or to a once-washed platelet suspension causes platelet aggregation. This aggregation is associated with phagocytosis of the latex particles by the platelets and appears to be due to release of adenosine diphosphate (ADP) from the platelets ...
H Z, Movat, W J, Weiser, M F, Glynn, J F, Mustard   +3 more
openaire   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Reduced platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis

Platelets, 2018
Results from previous studies regarding platelet function in liver cirrhosis are discordant. The aim was to investigate platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis.
Pernille Just Vinholt, Anne-Mette Hvas, Christian Nielsen, Anna Cecilia Söderström, Ulrik Sprogøe, Annette Dam Fialla, Mads Nybo   +6 more
doaj   +1 more source

TLR7, TLR9, MyD88, and NF-κB role on platelet aggregation in Yucatecan patients with type 2 diabetes

Revista de la Alad. Asociación Latinoamericana de Diabetes, 2022
Objective: To analyze the expression of TLR7, TLR9, and signaling proteins MyD88 and NF-κB, and their relationship with platelet aggregation in Yucatecan patients with type 2 diabetes.
Lucía G. González-Espinosa, Irma G. Quintal-Ortiz, Yumi E. Nakazawa-Ueji, Juan D. Villarreal-Ku, Ligia G. Alonso-Salomón, Isaac A. López-Briceño, Nina Valadez-González, Guillermo Valencia-Pacheco   +7 more
doaj   +1 more source

Glycine reduces platelet aggregation [PDF]

Amino Acids, 2012
It has been demonstrated that a wide variety of white blood cells and macrophages (i.e. Kupffer cells, alveolar and peritoneal macrophages and neutrophils) contain glycine-gated chloride channels. Binding of glycine on the receptor stimulates Cl− influx causing membrane hyperpolarization that prevents agonist-induced influx of calcium.
Peter, Schemmer, Zhi, Zhong, Uwe, Galli, Michael D, Wheeler, Li, Xiangli, Blair U, Bradford, Lars O, Conzelmann, Dow, Forman, José, Boyer, Ronald G, Thurman   +9 more
openaire   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source