Results 91 to 100 of about 16,295 (299)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Effects of amotosalen treatment on human platelet lysate bioactivity: A proof-of-concept study.

PLoS ONE, 2020
BACKGROUND:Clinical application of mesenchymal stromal cells (MSCs) usually requires an in vitro expansion step to reach clinically relevant numbers. In vitro cell expansion necessitates supplementation of basal mammalian cell culture medium with growth ...
Christian Christensen, Sandra Mjoll Jonsdottir-Buch, Olafur Eysteinn Sigurjonsson   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Soluble CD40L and CD62P levels differ in single‐donor apheresis platelet concentrates and buffy coat–derived pooled platelet concentrates

, 2018
International audienceBACKGROUND Platelet storage lesions are structural and biochemical changes in platelet concentrates (PCs), and depend on variables in collection and processing, as well as secondary procedures and storage conditions; such lesions ...
Chaker Aloui, Sandrine Laradi, Jocelyne Fagan, Hind Hamzeh‐Cognasse, Hamzeh-Cognasse, Hind, Caroline Sut, Tariket, Sofiane, Fagan, Jocelyne, Chavarin, Patricia, Sut, Caroline, Arthaud, Charles‐antoine, Sofiane Tariket, Olivier Garraud, Fabrice Cognasse, Laradi, Sandrine, Charles‐Antoine Arthaud, Aloui, Chaker, Marie‐Ange Eyraud, Eyraud, Marie‐ange, Garraud, Olivier, Cognasse, Fabrice, Patricia Chavarin   +21 more
core   +1 more source

Use of platelet concentrates in oral surgery of patients with osteonecrosis: a scoping review

, 2023
The objective of this study was to map, through a scoping review, the evidence available in the literature on the use of platelet concentrates in compromised patients undergoing oral surgeries. Searches were performed in electronic databases for clinical
Dionatan Zauza (15475243), Mateus Bertolini Fernandes dos Santos (5383826), Rafael Sarkis-Onofre (2806660), Mayara Colpo Prado (15475237), Yara T. C. Silva-Sousa (15475246), Carlos Eduardo Dutra Rufato (15475234), Renan Luiz Luft (15475240)   +6 more
core   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

High fragmentation in platelet concentrates impacts the activation, procoagulant, and aggregatory capacity of platelets

, 2023
Platelets are transfused to patients to prevent bleeding. Since both preparation and storage can impact the hemostatic functions of platelets, we studied platelet concentrates (PCs) with different initial composition in regard to platelet fragmentation ...
Dermot Kenny, Alshamari, Aseel,, Sandgren, Per, Mohammad R. Abedi (14394616), Vasilache, Ana-Maria, Abedi, MR, Tynngard, N, Ramstroem, S, Mohammad R. Abedi, Ramström, Sofia,, Tynngård, Nahreen,, Abedi, Mohammad R.,, Kenny, Dermot, Sofia Ramström (808839), Vasilache, Ana-Maria,, Per Sandgren, Sofia Ramström, Vasilache, Ana Maria,, Aseel Alshamari (14394607), Ana Maria Vasilache (14394613), Tynngård, Nahreen, Kenny, Dermot,, Sandgren, P,, Vasilache, AM, Aseel Alshamari, Abedi, Mohammad R., Ana Maria Vasilache, Nahreen Tynngård (686725), Dermot Kenny (202554), Alshamari, A, Ramström, Sofia, Kenny, D, Per Sandgren (14394610), Nahreen Tynngård, Sandgren, Per,, Alshamari, Aseel   +35 more
core   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source