Results 61 to 70 of about 28,987 (307)

Quality control in veterinary blood banks: evaluation of canine platelet concentrates stored for five days

BMC Veterinary Research, 2020
Background Platelets undergo structural, biochemical and functional alterations when stored, and platelet storage lesions reduce platelet function and half-life after transfusion.
Camila Serina Lasta, Nicole Hlavac, Natália Aydos Marcondes, Magnus Larruscaim Dalmolin, Silvia Resende Terra, Luciana de Almeida Lacerda, Gustavo Adolpho Moreira Faulhaber, Félix Hilário Díaz González   +7 more
doaj   +1 more source

Comparison of three commercially available buffy coat pooling sets for the preparation of platelet concentrates [PDF]

, 2018
Background: A disposable set for platelet concentrate (PC) preparation by the buffy coat method allows pooling of buffy coats, centrifugation and cell separation with in-line leucocyte filtration.
Aelst, Aelst, Drawz, Feys, Goodall, Hardwick, Hild, Irsch, Krailadsiri, Meer, Metcalfe, Vanaudenaerde   +11 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model [PDF]

, 2010
Current research aims to develop innovative approaches to improve chondral and osteochondral regeneration. The objective of this study was to investigate the regenerative potential of platelet-rich plasma (PRP) to enhance the repair process of a collagen-
Kon, Elizaveta, Filardo, Giuseppe, Delcogliano, Marco, Fini, Milena, Salamanna, Francesca, Giavaresi, Gianluca, Martin, Ivan, Marcacci, Maurilio   +7 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Bacterial Contamination of Blood Products Stored at Room Temperature on Agitator in Lagos State, Nigeria

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
BACKGROUND: The relevance of some plasma-based medicinal products, especially platelet concentrates in modern medical care, is confirmed by their inclusion in the World Health Organization Essential Medicines.
Tesleemah Oluwakemi Davies-Folorunso, Musa Abidemi Muhibi, Jamiu Bello Folorunso, Olufemi David Olaniyi, Abdulwaheed Adewale Ademosun, Nuryn Abdulganiy, Yekeen Adebisi Kosamat, Phoebe Nwamaka Kanikwu, Bodunrin Ibitola Osikomaiya, Mathew Folaranmi Olaniyan   +9 more
doaj   +1 more source

Frozen and cold-stored platelets: reconsidered platelet products

Platelets, 2022
Platelet transfusion, both prophylactic and therapeutic, is a key element in modern medicine. Currently, the standard platelet product for clinical use is platelet concentrates at room temperature (20–24°C) under gentle agitation.
Teresa Jimenez-Marco, Azucena Castrillo, Fernando Hierro-Riu, Vicente Vicente, José Rivera   +4 more
doaj   +1 more source

The Italian Regulatory Guidelines for the implementation of Patient Blood Management [PDF]

, 2017
Comment in Towards the implementation of patient blood management across Europe.
Antonioli, Paola, Biancofiore, Gianni, Gentili, Sara, Liumbruno, Giancarlo M., Marano, Giuseppe, Pupella, Simonetta, Rafanelli, Daniela, Vaglio, Stefania, Velati, Claudio   +8 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source