Results 81 to 90 of about 223,961 (265)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Morphology of cardiac and renal microvasculature in spontaneously hypertensive rat. Activity of thioctic acid [PDF]

, 2013
Accumulation of intimal vascular smooth muscle cells is a trait of atherosclerosis. Endothelial cells lining vascular luminal surface represent an important site of signalling and development of damage induced by reactive oxygen species (ROS) during ...
AMENTA, Francesco, Nwankow, EI, TAYEBATI, Seyed Khosrow, TOMASSONI, Daniele   +3 more
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Collaborative enhancement of antibody binding to distinct PECAM-1 epitopes modulates endothelial targeting. [PDF]

PLoS ONE, 2012
Antibodies to platelet endothelial cell adhesion molecule-1 (PECAM-1) facilitate targeted drug delivery to endothelial cells by "vascular immunotargeting." To define the targeting quantitatively, we investigated the endothelial binding of monoclonal ...
Ann-Marie Chacko, Madhura Nayak, Colin F Greineder, Horace M Delisser, Vladimir R Muzykantov   +4 more
doaj   +1 more source

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane

Journal of Experimental Medicine, 1996
Platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) plays an active role in the process of leukocyte migration through cultured endothelial cells in vitro and anti-PECAM-1 antibodies (Abs) inhibit accumulation of leukocytes into sites of ...
M. Wakelin, M J Sanz, A. Dewar, S. Albelda, S. Larkin, N. Boughton-Smith, T. Williams, S. Nourshargh   +7 more
semanticscholar   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Heparan Sulfates Mediate the Interaction between Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and the Gαq/11 Subunits of Heterotrimeric G Proteins*

Journal of Biological Chemistry, 2014
Background: The mechanisms by which the PECAM-1·Gαq/11 mechanosensitive complex mediates endothelial flow responses remain unclear. Results: The PECAM-1·Gαq/11 complex contains heparan sulfate proteoglycans (HSPGs) and is disrupted by inhibition of HS ...
Nathaniel G. dela Paz, B. Melchior, Francisca Y Shayo, J. Frangos   +3 more
semanticscholar   +1 more source

Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season [PDF]

, 2010
Background and Objective Air temperature changes are associated with increased cardiovascular and respiratory risk, but the roles of inflammatory and coagulation markers are not well understood.
Breitner, Susanne, Frampton, Mark W., Hampel, Regina, Koenig, Wolfgang, Peters, Annette, Phipps, Richard P., Rückerl, Regina, Schneider, Alexandra, Wichmann, Heinz-Erich   +8 more
core   +1 more source

Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass‐Released Ions

Advanced Functional Materials, EarlyView.
A mechanically tunable hydrogel composed of gelatin, chondroitin sulfate and laminin promotes angiogenesis in vitro without the supplement of growth factors. Endothelial cells morphogenesis was further enhanced by medium conditioned with bioactive glass 58S‐released ions (Ca and Si), thus offering a promising strategy to vascularize 3D tissue ...
Marco Piazzoni, Ilaria Borghi, Francesca Cadamuro, Sophia Dalfino, Riccardo Campanile, Sofia Nizzolo, Valeria Cassina, Francesca Tallia, Julian R. Jones, Francesco Mantegazza, Sabrina Bertini, Lorenzo Moroni, Francesco Nicotra, Laura Russo   +13 more
wiley   +1 more source

Inhibition of platelet-activating factor, intercellular adhesion molecule 1 and platelet endothelial cell adhesion molecule 1 reduces experimental pancreatitis-associated gut endothelial barrier dysfunction

Journal of British Surgery, 1999
Abstract Background Endothelial barrier dysfunction is a critical link in the development of tissue injury and organ dysfunction, via upregulation and exposure of adhesion molecules, intercellular signals and leucocyte–endothelial cell interactions.
X, Wang, Z, Sun, A, Börjesson, R, Andersson   +3 more
openaire   +2 more sources