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Platelet Function in Aging [PDF]
Frontiers in Cardiovascular Medicine, 2019 Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders.
Jessica Le Blanc +3 more
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Corrigendum: The Effect of a Simulated Commercial Flight Environment With Hypoxia and Low Humidity on Clotting, Platelet, and Endothelial Function in Participants With Type 2 Diabetes – A Cross-Over Study [PDF]
Frontiers in Endocrinology, 2018 Aims: To determine if clotting, platelet, and endothelial function were affected by simulated short-haul commercial air flight conditions (SF) in participants with type 2 diabetes (T2DM) compared to controls. Methods: 10 participants with T2DM (7 females,
Judit Konya +9 more
doaj +6 more sources
Platelet function and ageing [PDF]
Mammalian Genome, 2016 There are clear age-related changes in platelet count and function, driven by changes in hematopoietic tissue, the composition of the blood and vascular health.
Jones, Chris I.
core +5 more sources
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
Frontiers in Cardiovascular Medicine, 2021 The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet ...
Jiayu Wu +3 more
doaj +1 more source
Aquaporins in platelet function
Platelets, 2021 Structurally, aquaporins (AQPs) are small channel proteins with monomers of ~ 30 kDa that are assembled as tetramers to form pores on cell membranes. Aquaporins mediate the conduction of water but at times also small solutes including glycerol across ...
Ejaife O. Agbani, Alastair W. Poole
doaj +1 more source
Tzu Chi Medical Journal, 2022 Platelets play an essential role in primary hemostasis through bleeding and thromboembolism. Thus, the diagnosis or evaluation of impaired hereditary, acquired, and drug-related platelet dysfunction has become imperative.
Chih-Lung Shen, Yi-Feng Wu
doaj +1 more source
Platelet function defects [PDF]
Haemophilia, 2008 Summary. Inherited defects of platelet function are a heterogeneous group of disorders that can result in bleeding symptoms ranging from mild bruising to severe mucocutaneous haemorrhage. These defects may be classified according to their effect on the various steps of platelet microthrombi formation including initiation, extension and cohesion, or ...
D, Simon, T, Kunicki, D, Nugent
openaire +2 more sources
Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]
, 2020 Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar +45 more
core +1 more source
JACC: Basic to Translational Science, 2022 Summary: Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood.
Rahim Kanji, MB, BS +5 more
doaj +1 more source
Epidural hematoma after thoracic epidural analgesia in a patient treated with ketorolac, mefenamic acid, and naftazone: a case report [PDF]
Korean Journal of Anesthesiology, 2014 A 26-year-old male undergoing thoracotomy and bleeding control received a preoperative thoracic epidural for postoperative analgesia. On the fifth postoperative day, paralysis of both lower limbs occurred and urgent magnetic resonance imaging showed ...
Dae Geun Jeon +3 more
doaj +1 more source