Results 1 to 10 of about 732,255 (167)
Seminars in Thrombosis and Hemostasis, 2016 Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate ...
Lordkipanidzé, Marie
core +5 more sources
A Wigner-Seitz model of charged lamellar colloidal dispersions [PDF]
Phys. Rev. E 56, 3137 (1997)., 1997 A concentrated suspension of lamellar colloidal particles (e. g. clay) is modelled by considering a single, uniformly charged, finite platelet confined with co- and counterions to a Wigner-Seitz (WS) cell. The system is treated within Poisson-Boltzmann theory, with appropriate boundary conditions on the surface of the WS cell, supposed to account for ...
Hansen, Jean-Pierre, Trizac, Emmanuel
arxiv +3 more sources
Platelet function and ageing [PDF]
Mammalian Genome, 2016 There are clear age-related changes in platelet count and function, driven by changes in hematopoietic tissue, the composition of the blood and vascular health.
Jones, Chris I.
core +5 more sources
Platelet function in aging [PDF]
Frontiers in Cardiovascular Medicine, 2019 Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders.
Le Blanc, Jessica, Lordkipanidzé, Marie
core +7 more sources
Aquaporins in platelet function [PDF]
Platelets, 2021 Structurally, aquaporins (AQPs) are small channel proteins with monomers of ~ 30 kDa that are assembled as tetramers to form pores on cell membranes. Aquaporins mediate the conduction of water but at times also small solutes including glycerol across cell membranes and along osmotic gradients.
Ejaife O. Agbani, Alastair W. Poole
openaire +4 more sources
High platelet reactivity in patients with acute coronary syndromes undergoing percutaneous coronary intervention: Randomised controlled trial comparing prasugrel and clopidogrel [PDF]
, 2015 Background: Prasugrel is more effective than clopidogrel in reducing platelet aggregation in acute coronary syndromes. Data available on prasugrel reloading in clopidogrel treated patients with high residual platelet reactivity (HRPR) i.e.
76-87 Ferri +44 more
core +8 more sources
Assay validity of point-of-care platelet function tests in thrombocytopenic blood samples [PDF]
, 2022 Point-of-care (POC) platelet function tests are faster and easier to perform than in-depth assessment by flow cytometry. At low platelet counts, however, POC tests are prone to assess platelet function incorrectly. Lower limits of platelet count required
Eichelberger, Beate +6 more
core +2 more sources
Immersed boundary simulations of cell-cell interactions in whole blood [PDF]
, 2021 We present a new method for the geometric reconstruction of elastic surfaces simulated by the immersed boundary method with the goal of simulating the motion and interactions of cells in whole blood. Our method uses parameter-free radial basis functions for high-order meshless parametric reconstruction of point clouds and the elastic force computations
arxiv +1 more source
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]
, 2018 The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P. +6 more
core +4 more sources
The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]
, 2016 A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai +5 more
core +4 more sources