Results 251 to 260 of about 5,714,223 (293)
Some of the next articles are maybe not open access.
Cyclooxygenases and platelet functions
2023Cyclooxygenase (COX) isozymes, i.e., COX-1 and COX-2, are encoded by separate genes and are involved in the generation of the same products, prostaglandin (PG)G2 and PGH2 from arachidonic acid (AA) by the COX and peroxidase activities of the enzymes, respectively.
Bruno A. +4 more
openaire +2 more sources
Platelet function in hypertension
Blood Cells, Molecules, and Diseases, 2009Platelets from hypertensive patients show increased sensitivity to agonists and have high intracellular free Ca(2+) concentration. Furthermore, in hypertension, platelets show enhanced endogenous production of reactive oxygen species and a reduced antioxidant status which increases protein tyrosine phosphorylation, enhances Ca(2+) mobilization and ...
Mohammed, El Haouari, Juan A, Rosado
openaire +2 more sources
Platelet Function in Preleukaemia
Scandinavian Journal of Haematology, 1981Platelet function was studied in 17 patients with preleukaemia and the results were compared with those of 28 patients with other chronic myeloproliferative disorders. The test pattern included bleeding time (Ivy), platelet retention (Hellem II), PF‐3 activity and availability after exposure to ADP and kaolin, and ADP‐, epinephrine‐, collagen‐ and ...
R, Lintula +4 more
openaire +2 more sources
1993
Platelets contain multiple low molecular weight GTP-binding proteins which share strong sequence similarity to ras including rap, rac, ral, and rho (Nagata et al., 1989; Polakis et al., 1989). In addition, platelets contain regulatory molecules which both control the hydrolysis of GTP bound to the protein and/or promote the exchange of GDP for GTP ...
E G, Lapetina, F X, Farrell
openaire +2 more sources
Platelets contain multiple low molecular weight GTP-binding proteins which share strong sequence similarity to ras including rap, rac, ral, and rho (Nagata et al., 1989; Polakis et al., 1989). In addition, platelets contain regulatory molecules which both control the hydrolysis of GTP bound to the protein and/or promote the exchange of GDP for GTP ...
E G, Lapetina, F X, Farrell
openaire +2 more sources
The functional dissonance of platelets
Blood, 2012In this issue of Blood , Cloutier et al answer a long-standing but unappreciated question about the influence of platelets on vascular permeability.[1][1] The role of platelets in responding to vascular injury and the prevention blood loss is very well understood.
Enming Joseph, Su, Daniel A, Lawrence
openaire +2 more sources
Clinics in Perinatology, 2015
Similarly to the development of the plasma coagulation system, which matures during the early weeks and months of life, age-dependent mechanisms and developmental changes influence platelet production and function in neonates. Platelet function testing on cord blood and peripheral blood demonstrates a generalized platelet hyporeactivity, during the ...
Del Vecchio, A +2 more
openaire +2 more sources
Similarly to the development of the plasma coagulation system, which matures during the early weeks and months of life, age-dependent mechanisms and developmental changes influence platelet production and function in neonates. Platelet function testing on cord blood and peripheral blood demonstrates a generalized platelet hyporeactivity, during the ...
Del Vecchio, A +2 more
openaire +2 more sources
Platelet Function in Hyperlipoproteinemia
New England Journal of Medicine, 1974Abstract Platelet function was studied in 17 patients with Type II hyperlipoproteinemia. As compared with 26 normal subjects, platelets from patients with the Type II syndrome aggregated in response to 1/25 the mean concentration of epinephrine, one third the concentration of collagen, and one third the concentration of ADP.
A C, Carvalho, R W, Colman, R S, Lees
openaire +2 more sources
Vincristine and Platelet Function
JAMA: The Journal of the American Medical Association, 1982To the Editor.— In their article on the "Treatment of Thrombotic Thrombocytopenic Purpura With Vincristine" (1982;247:1433), Gutterman and Stevenson attribute the possible beneficial effect of the drug to its effect on the endothelial cells. 1 They consider the vincristine sulfate treatment aside from agents that inhibit platelet aggregation, and ...
P G, Steinherz, D R, Miller
openaire +2 more sources
Haemophilia, 2000
Platelet function defects comprise a large and heterogeneous group of bleeding disorders that range in severity from mild to severe. Patients may be asymptomatic; however, the majority who are diagnosed present with easy bruising and mucocutaneous bleeding, or with excessive haemorrhage following injury or surgery.
openaire +2 more sources
Platelet function defects comprise a large and heterogeneous group of bleeding disorders that range in severity from mild to severe. Patients may be asymptomatic; however, the majority who are diagnosed present with easy bruising and mucocutaneous bleeding, or with excessive haemorrhage following injury or surgery.
openaire +2 more sources
Sulfonylureas and platelet function
The American Journal of Medicine, 1981The platelets of many patients with diabetes mellitus are abnormally sensitive to the effects of aggregatory agents in vitro. It has been proposed that this abnormal platelet function may play a role in the pathogenesis of vascular disease in diabetic subjects.
L J, Klaff +4 more
openaire +2 more sources