Results 41 to 50 of about 162,912 (259)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Effects of pH and concentration of sodium citrate anticoagulant on platelet aggregation measured by light transmission aggregometry induced by adenosine diphosphate

Platelets, 2018
The 2013 ISTH-SSC guidelines for the standardization of light transmission aggregometry (LTA) were largely based on expert consensus, as studies directly comparing LTA methodologies were lacking.
Ksenia Germanovich, Eti Alessandra Femia, Chun Yan Cheng, Natalia Dovlatova, Marco Cattaneo   +4 more
doaj   +1 more source

Platelet Function Test–Guided Strategy [PDF]

Circulation: Cardiovascular Interventions, 2015
In this issue of Circulation: Cardiovascular Interventions , Wang et al1 publish on the real-world impact of platelet function testing where clinicians have direct access to point-of-care platelet function testing without protocol-mandated treatment strategies.
Jean-Philippe, Collet, Johanne, Silvain, Gilles, Montalescot   +2 more
openaire   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Inconsistency of different methods for assessing ex vivo platelet function: relevance for the detection of aspirin resistance

Haematologica, 2010
Background Assays to evaluate platelet function are often interchangeably used to assess “resistance” to aspirin. We compared different platelet function assays in patients treated or untreated with aspirin.Design and Methods Platelet function was ...
Giulia Renda, Maria Zurro, Gelsomina Malatesta, Benedetta Ruggieri, Raffaele De Caterina   +4 more
doaj   +1 more source

Conundrums of Platelet Function Testing [PDF]

Circulation: Cardiovascular Interventions, 2017
It is well established that there exists significant interpatient variability in the pharmacodynamic response to clopidogrel.1,2 In turn, multiple studies have demonstrated that higher on-treatment platelet reactivity is associated with an increased risk of cardiovascular events.3 Although thresholds for inadequate response have been proposed, the ...
Amy, Sarma, Michelle L, O'Donoghue
openaire   +2 more sources

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding

Platelets, 2019
Heavy menstrual bleeding (HMB) is often undiagnosed in women and can cause discomfort and distress. A haemostatic cause for excessive bleeding is often not routinely investigated and can lead to hysterectomy at an early age.
Gillian C. Lowe, Roksana Fickowska, Rashid Al Ghaithi, Annabel Maclachlan, Paul Harrison, Will Lester, Steve P. Watson, Bethan Myers, Justin Clark, Neil V. Morgan   +9 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source