Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives
American Journal of Hematology, Volume 100, Issue S4, Page 30-50, June 2025.ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley +1 more source
American Journal of Hematology, Volume 100, Issue S4, Page 16-29, June 2025.ABSTRACT Allogeneic hematopoietic stem‐cell transplantation (HCT) remains the only potentially curative therapy for patients with myelodysplastic neoplasms (MDS) and myelofibrosis (MF) and is the standard care for eligible patients with higher‐risk disease. Despite significant advancements, both diseases pose unique challenges due to their clinical and
Nico Gagelmann, Nicolaus Kröger
wiley +1 more source
PDGF‐D Promotes Epithelial–Mesenchymal Transition of Glioma Cells Through the NF‐κB/NOTCH1 Pathway
Cancer Medicine, Volume 14, Issue 12, June 2025.ABSTRACT Background Platelet‐derived growth factor‐D (PDGF‐D) is expressed at high levels in various tumors and is involved in epithelial–mesenchymal transition (EMT) and the malignant behavior of cancer cells. However, its role in glioma progression and the underlying molecular mechanisms remain unclear.
Yao Li +8 more
wiley +1 more source
Prevalence, Risk Factors and Outcomes of Platelet Transfusion Refractoriness in Critically Ill Patients: A Retrospective Cohort Study [PDF]
, 2020 Saeed Arabi +5 more
openalex +1 more source
Echis carinatus Snakebite, a Rare Fatal Envenomation Incident in a Young Pakistani Boy: Case Report
Clinical Case Reports, Volume 13, Issue 6, June 2025.ABSTRACT Prompt identification and aggressive intervention in Echis carinatus envenomation are paramount to avert life‐threatening complications such as venom‐induced consumptive coagulopathy (VICC), acute renal failure (ARF), and necrotizing fasciitis.
Farina Fatima Siddiqui +8 more
wiley +1 more source
What is your diagnosis? Abnormal cluster on the WDF and WNR scattergrams from Sysmex XN‐V in a dog
Veterinary Clinical Pathology, EarlyView.
Theo Chenal +3 more
wiley +1 more source
Changes in inflammatory responses and autophagy during apheresis platelet preservation and their correlation with platelet transfusion refractoriness in patients with acute lymphoblastic leukemia. [PDF]
Biomol Biomed, 2023 Li Y, Song Z, Sun X, Tang J, Zhou X.
europepmc +1 more source
Platelet transfusions: trigger, dose, benefits, and risks [PDF]
Over the last half century, platelet transfusion has been an effective therapy for the prevention and treatment of bleeding, particularly in patients with hematologic malignancies.
Blumberg, Neil +2 more
core +2 more sources
Transfusion: Predict the Next Token and Diffuse Images with One Multi-Modal Model [PDF]
arXivWe introduce Transfusion, a recipe for training a multi-modal model over discrete and continuous data. Transfusion combines the language modeling loss function (next token prediction) with diffusion to train a single transformer over mixed-modality sequences.
arxiv
Primary refractoriness to platelet transfusion caused by Naka antibody alone [PDF]
, 2002 H. Fujino +13 more
openalex +1 more source