Results 121 to 130 of about 3,822 (260)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness [PDF]

, 1992
Mitsuru Murata, Kenichi Furihata, Fumihiro Ishida, SR Russell, Jerry Ware, ZM Ruggeri   +5 more
openalex   +3 more sources

Platelet Refractory Cases after Transfusion of Fresh and Stored Platelet in all Children

, 2022
Alamgir Ahmed, Mafruha Akhter, Md. Mizanur Rahman, Mohammad Ali, Dr. Md. Kamrul Hossain, Lokesh Chakraborty, S. M. Masud, Salma Sadiya, Rawshan Ara, Delara Sultana   +9 more
openalex   +1 more source

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source

Correlation of heavy metals and theirs impact to epidemiological survey in the miners blood donors and other human population [PDF]

, 2011
Introduction: Miners who are blood donors, and work in mines for lead-zinc ores are constantly exposed to heavy metals (lead, zinc and cadmium) and this aspect is expected to increase or decrease many hematological parameters.
Kamcev, Nikola, Kamceva, Gordana, Panov, Zoran, Velickova, Nevenka   +3 more
core  

Prevention from transfusion transmissive diseases in the regional center for transfusion medicine in Stip, Republic of Macedonia for the period 2009-2010 [PDF]

, 2011
Introduction: Blood transfusion is a transplantation of fluid tissue or an introduction of human biological material that needs to survive in the donor organism and to play important biological functions. During the blood and blood products transfusion,
Kamcev, Nikola, Kamceva, Gordana, Velickova, Nevenka   +2 more
core  

Recognition and management of platelet-refractory bleeding in patients with Glanzmann’s thrombasthenia and other severe platelet function disorders

International Journal of General Medicine, 2017
Meera Chitlur,1 Madhvi Rajpurkar,1 Michael Recht,2 Michael D Tarantino,3 Donald L Yee,4 David L Cooper,5 Sriya Gunawardena5 1Carman and Ann Adams Department of Pediatrics, Wayne State University and Children’s Hospital of Michigan, Detroit, MI, USA;
Chitlur M, Rajpurkar M, Recht M, Tarantino MD, Yee DL, Cooper DL, Gunawardena S   +6 more
doaj  

Antiplatelet antibodies in patients with ITP and patient with platelet refractoriness

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Background: Immune thrombocytopenic purpura is an acquired disorder, in which accelerated platelet consumption is due to PLT autoantibodies. The diagnosis of immune thrombocytopenic purpura is a diagnosis of exclusion.
Salah Aref, Lamiaa Ebrahim, Tarek Selim
doaj  

Research progress on prevention strategies for immune platelet transfusion refractoriness

Zhongguo shuxue zazhi
Platelet transfusion refractoriness (PTR) is a common issue among patients with hematological diseases and tumors. This article reviews the diagnostic criteria, influencing factors, and recent prevention and management strategies for immune PTR.
ZHAO Peizhe, XU Yi, LIANG Yajun, LI Qing, ZHOU Yuan, XU Xianguo   +5 more
doaj   +1 more source

[Chinese expert consensus on the diagnosis and management of platelet transfusion refractoriness (2022)]. [PDF]

Zhonghua Xue Ye Xue Za Zhi, 2022
Chinese Society of Hematology, Chinese Medical Association.   +1 more
europepmc   +1 more source