Results 101 to 110 of about 48,011 (239)

Clinical application of a modified platelet desialylation test for mechanistic characterization of platelet transfusion refractoriness

Transfusion, EarlyView.
Abstract Background Platelet transfusion refractoriness (PTR) is a major challenge in transfusion medicine and may result from both immune and non‐immune mechanisms. Although alloantibodies are well‐established contributors, Fc‐independent pathways such as platelet desialylation have emerged as alternative mechanisms of clearance.
Karen Ziza, Thamy Silva, Mateus Domentino, Marina Conrado, João Oliveira, Elyse Moritz, Akemi Chiba, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Langhi Dante, Carla Dinardo   +11 more
wiley   +1 more source

Transfusão de plaquetas: do empirismo ao embasamento científico Platelet transfusion: from empiricism to scientific evidence

Revista Brasileira de Hematologia e Hemoterapia, 2010
Despite major advances in Brazilian blood transfusion therapy with a growing number of scientific publications, an increased number of repeat donors and a decline in serological ineligibility, a lack of conformity in the application of pre-transfusion ...
Aline A. Ferreira, Sheila Soares, Vagner de Castro, Helio Moraes-Souza   +3 more
doaj   +1 more source

Pediatric transfusion camp: Developing, piloting and evaluation of a Canadian national pediatric transfusion medicine curriculum

Transfusion, EarlyView.
Abstract Background Standardized post‐graduate education in pediatric transfusion medicine remains limited. The objective of this study was to adapt an adult transfusion education program, Transfusion Camp, to include pediatric content and assess knowledge improvement in pediatric subspecialty trainees.
Ines Zuna, Valérie Arsenault, Kimmo Murto, Suzanne Beno, MacGregor Steele, Jennifer Young, Sarah Leir, Angela Punnett, Cheryl Peters, Lucille Barcat, Yulia Lin, Casey Kapitany, Sophie Chargé, Teresa Skelton, Lani Lieberman   +14 more
wiley   +1 more source

Usefulness of pegfilgrastim for allogeneic peripheral blood stem cell collection from healthy donors

Transfusion, EarlyView.
Abstract Background Granulocyte colony‐stimulating factor (G‐CSF)‐based mobilization is essential for peripheral blood stem cell (PBSC) collection for allogeneic transplantation. Conventional daily G‐CSF requires repeated dosing and dose adjustment and often necessitates leukapheresis over multiple consecutive days, increasing donor burden. Single‐dose
Tomoshige Shimizu, Tomoyasu Jo, Noriyoshi Yoshinaga, Takashi Sakamoto, Hiroyuki Matsui, Toshio Kitawaki, Junya Kanda, Momoko Nishikori, Kouhei Yamashita, Miki Nagao, Akifumi Takaori‐Kondo, Yasuyuki Arai   +11 more
wiley   +1 more source

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Population Pharmacokinetics of Ticagrelor during Veno‐Arterial ECMO in Acute Coronary Syndrome: Model‐Informed Dosing Simulations

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 193-202, July 2026.
Although patients with acute coronary syndrome supported by veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) have a high risk of thrombosis and bleeding, antiplatelet pharmacology in this setting is not well defined. This prospective observational study investigated the population pharmacokinetics of ticagrelor and its active metabolite AR ...
Soyoung Kang, Kyoung Lok Min, Seungwon Yang, Jongsung Hahn, Dasohm Kim, Byung Hak Jin, Soon Uk Chae, Soo Kyung Bae, Jin Wi, Min Jung Chang   +9 more
wiley   +1 more source

Evaluation of the platelet cross-matching in oncology patients

Global Journal of Transfusion Medicine, 2016
Context: Platelet transfusion is an essential part of managing cancer. Refractoriness to platelet transfusion poses great challenge in the treatment of thrombocytopenic patients.
Sadhana Mangwana, Nikhil Simon
doaj   +1 more source

Loncastuximab Tesirine in Relapsed/Refractory Diffuse Large B‐Cell Lymphoma: Evidence and Practical Guidance From Italian Clinical Experience

European Journal of Haematology, Volume 117, Issue 1, Page 144-153, July 2026.
ABSTRACT Patients with relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) who progress to the third‐line setting face a lack of standardized treatment, despite the presence of multiple available therapies. In this context, antibody–drug conjugates represent a relatively new class of anticancer agents; among them, loncastuximab tesirine is ...
Francesca Bonello, Andrea Aroldi, Alessia Castellino, Lara Mannelli, Elia Boccellato, Serena Rosati, Luisa Verga, Umberto Vitolo   +7 more
wiley   +1 more source

First platelet transfusion refractoriness in a patient with acute myelocytic leukemia: A case report. [PDF]

World J Clin Cases, 2023
Tu SK, Fan HJ, Shi ZW, Li XL, Li M, Song K.   +5 more
europepmc   +1 more source

Epitope-Based Matching for Hla-Alloimmunized Platelet Refractoriness in Patients with Hematologic Diseases

, 2011
BACKGROUND: For HLA-alloimmunized patients, platelet (PLT) concentrations are provided either at matched HLA-A and HLA- B loci or by serologic cross-reactivity groups (CREG) matching strategy However, this method has some limitations STUDY DESIGN AND ...
白舜仲;羅仕錡;林素娟;林東燦;林國信;林亮音, PAI, SHUN-CHUNG;LO, SHYH-CHYI;TSAI, SU-JEN LIN;LIN, DONG-TSAMN;LIN, KUO-SIN;LIN, LIANG-IN   +1 more
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