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1999
Abstract Plectin is a versatile cytoskeletal linker protein of high molecular weight (>500 000 Da) that is abundantly expressed in a wide variety of mammalian tissues and cell types. It interacts with all major cytoskeletal filament networks and is a major constituent of plasma membrane-associated junctional complexes (e.g ...
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Abstract Plectin is a versatile cytoskeletal linker protein of high molecular weight (>500 000 Da) that is abundantly expressed in a wide variety of mammalian tissues and cell types. It interacts with all major cytoskeletal filament networks and is a major constituent of plasma membrane-associated junctional complexes (e.g ...
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Role of plectin in cytoskeleton organization and dynamics
Journal of Cell Science, 1998ABSTRACT Plectin and its isoforms are versatile cytoskeletal linker proteins of very large size (>500 kDa) that are abundantly expressed in a wide variety of mammalian tissues and cell types. Earlier studies indicated that plectin molecules were associated with and/or directly bound to subcomponents of all three major cytoskeletal
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2008
Das Cytolinkerprotein Plectin spielt bei der Aufrechterhaltung der Integrität des Zytoskeletts eine entscheidende Rolle, indem es Intermediärfilamente (IFs) mit anderen zytoskelettären Netzwerksystemen verbindet und diese an der Plasmamembran verankert. Weiters dient es als strukturelles Grundgerüst für Signalkaskaden und dürfte ebenfalls eine Funktion
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Das Cytolinkerprotein Plectin spielt bei der Aufrechterhaltung der Integrität des Zytoskeletts eine entscheidende Rolle, indem es Intermediärfilamente (IFs) mit anderen zytoskelettären Netzwerksystemen verbindet und diese an der Plasmamembran verankert. Weiters dient es als strukturelles Grundgerüst für Signalkaskaden und dürfte ebenfalls eine Funktion
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Brains and brawn: plectin as regulator and reinforcer of the cytoskeleton
BioEssays, 1999Plectin is a 580 kDa intracellular protein, previously shown to link intermediate filaments with microtubules, actin filaments, and membrane components. Disruption of the plectin gene in humans and in mice results in severe skin blistering and muscular degeneration, consistent with plectin's structural role in stabilizing cells against mechanical force.
P G, Allen, J V, Shah
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Functional and Genetic Analysis of Plectin in Skin and Muscle
2016Plectin is a large cytoskeletal linker protein with a multitude of functions affecting various cellular processes. It is expressed as several different isoforms from a highly complex gene. Both, this transcript diversity (mainly caused by short 5'-sequences contained in alternative first exons) and the size (>500 kDa) of the resulting proteins, present
Rezniczek, Günther A. +3 more
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Plectin, an unusual target antigen in bullous pemphigoid
British Journal of Dermatology, 2001Bullous pemphigoid (BP) is a blistering disease associated with autoantibodies directed against two components of hemidesmosomes, BP180 and BP230.To assess whether BP patients have autoantibodies targeting plectin, another hemidesmosomal component showing extensive homology to BP230.Examination of sera from 16 patients with BP, using ...
E, Laffitte +7 more
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Expression of plectin in muscle fibers with cytoarchitectural abnormalities
Neuromuscular Disorders, 2003Plectin is a protein belonging to the cytoskeletal anchoring system, concentrated at sites of mechanical stress in different cell types. In normal skeletal muscle, plectin is located at level of Z-discs, sarcolemma, post-synaptic membrane, and intermyofibrillar network.
VITA, Giuseppe +3 more
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Molecular, structural, and in vivo analysis of the dominant plectin mutation plectin EBS-Ogna
2015Plectin, ein großes multifunktionelles Cytoskelettprotein vernetzt Intermediärfilamente und vermittelt ihre Interaktion mit Aktinfilamenten und Mikrotubuli, den beiden anderen Cytoskelett-Filamentsystemen. Plectin verankert auch Intermediärfilamente an strategisch wichtigen Stellen der Zelle, wie Hemidesmosomen in basalen Keratinozyten, Costamere, Z ...
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Structure of the plakin domain of plectin
2016Plectin is a member of the plakin family of proteins that cross-links components of the cytoskeleton and link them to membrane-associated structures, such as hemidesmosomes. Plectin has a multi-domain structure. The N-terminal region contains a conserved domain terme the plakin domain that consists of an array of 9 Spectrin Repeats (SR1 to SR9 ...
Ortega, Esther +2 more
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