Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. [PDF]
, 2019 Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously.
Blondelle, Jordan +13 more
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Plectin-1 targeted AAV vector for the molecular imaging of pancreatic cancer
Frontiers in Oncology, 2013 Pancreatic ductal adenocarcinoma (PDAC) is highly malignant disease that is the 4th leading cause of cancer-related death in the US. Gene therapy using AAV vectors to selectively deliver genes to PDAC cells is an attractive treatment option for ...
Prasad R. Konkalmatt +6 more
doaj +1 more source
Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility [PDF]
, 2016 The genetic basis of epidermolysis bullosa, a group of genetic disorders characterized by the mechanically induced formation of skin blisters, is largely known, but a number of cases still remain genetically unsolved.
Boerries, Melanie +15 more
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Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation
Biology Open, 2016 The Deleted in liver cancer 1 (Dlc1) gene codes for a Rho GTPase-activating protein that also acts as a tumour suppressor gene. Several studies have consistently found that overexpression leads to excessive cell elongation, cytoskeleton changes and ...
Mohammad G. Sabbir +2 more
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Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: A hypothesis [PDF]
, 2012 Despite extensive understanding of sleep regulation, the molecular-level cause and function of sleep are unknown. I suggest that they originate in individual neurons and stem from increased production of protein fragments during wakefulness.
Varshavsky, Alexander
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The Role of Plectin in Pancreatic Cancer [PDF]
, 2017 Pancreatic ductal adenocarcinoma (PDAC) is an intractable clinical problem. It is the fourth leading cause of cancer deaths in the United States and the five-year survival rate of PDAC is only 6%. The prognosis remains poor due to its highly aggressive nature and resistance to extant therapies.
openaire +1 more source
The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression [PDF]
, 2016 Neuroblastoma is the second-most common solid tumor in children and originates from poorly differentiated neural crest-derived progenitors. Although most advanced stage metastatic neuroblastoma patients initially respond to treatment, a therapy resistant
Clark, K +7 more
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Early targets of miR-34a in neuroblastoma [PDF]
, 2014 Several genes encoding for proteins involved in proliferation, invasion, and apoptosis are known to be direct miR-34a targets. Here, we used proteomics to screen for targets of miR-34a in neuroblastoma (NBL), a childhood cancer that originates from ...
Aiese, N +20 more
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Reconstitution of cytolinker-mediated crosstalk between actin and vimentin
European Journal of Cell BiologyCell shape and motility are determined by the cytoskeleton, an interpenetrating network of actin filaments, microtubules, and intermediate filaments. The biophysical properties of each filament type individually have been studied extensively by cell-free
Irene Istúriz Petitjean +6 more
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Analyse phénotypique et génotypique de 30 patients ayant une épidermolyse bulleuse héréditaire de type jonctionnelle avec mutations du gène codant pour le collagène XVII, COL17A1 [PDF]
IntroductionL’épidermolyse bulleuse héréditaire de type jonctionnelle (JEB) associée à des mutations du gène COL17A1 est une génodermatose rare caractérisée par une fragilité cutanéomuqueuse due à une altération de l'expression du collagène de type XVII,
Hérissé, Anne-Laure
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