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Role of plectin and its interacting molecules in cancer
Medical Oncology, 2023Plectin, as the cytolinker and scaffolding protein, are widely expressed and abundant in many tissues, and has involved in various cellular activities contributing to tumorigenesis, such as cell adhesion, migration, and signal transduction. Due to the specific expression and differential localization of plectin in cancer, most researchers focus on the ...
Jiehui Di, Li Hailong
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Proteolysis of Liver Plectin by μ-Calpain
Biochemical and Biophysical Research Communications, 1998Rat liver plectin was found to be mainly associated with plasma membrane fractions enriched in junctional complexes. The membrane-associated plectin has been partially isolated. Plectin co-purifies with a 200 kDa polypeptide which, on the basis of sequence homology, has been identified as a myosin like-protein.
Muenchbach M +2 more
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Structure and hydrodynamic properties of plectin molecules
Journal of Molecular Biology, 1987Plectin is a cytoskeletal, high molecular weight protein of widespread and abundant occurrence in cultured cells and tissues. To study its molecular structure, the protein was purified from rat glioma C6 cells and subjected to chemical and biophysical analyses.
R, Foisner, G, Wiche
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The many faces of plectin and plectinopathies: pathology and mechanisms
Acta Neuropathologica, 2012Plectin, a giant multifunctional cytolinker protein, plays a crucial role in stabilizing and orchestrating intermediate filament networks in cells. Mutations in the human plectin gene result in multiple diseases manifesting with muscular dystrophy, skin blistering, and signs of neuropathy.
Gerhard Wiche +2 more
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Journal of Dermatological Science, 2015
Plectin has been characterized as a linker protein that is expressed in many cell types and is distinctive in various isoforms in the N-terminus and around the rod domain due to complicated alternative splicing of PLEC, the gene encoding plectin. Plectin deficiency causes autosomal recessive epidermolysis bullosa simplex (EBS) with involvement of the ...
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Plectin has been characterized as a linker protein that is expressed in many cell types and is distinctive in various isoforms in the N-terminus and around the rod domain due to complicated alternative splicing of PLEC, the gene encoding plectin. Plectin deficiency causes autosomal recessive epidermolysis bullosa simplex (EBS) with involvement of the ...
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1999
Just over 25 years ago, De Weerdt and Castelain [1] described the combination of progressive muscular weakness and dystrophic epidermolysis bullosa with an autosomal recessive pattern. Niemi et al. [2] described a Finnish sibship with normal parents and 12 members.
Stephanie Lateo +4 more
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Just over 25 years ago, De Weerdt and Castelain [1] described the combination of progressive muscular weakness and dystrophic epidermolysis bullosa with an autosomal recessive pattern. Niemi et al. [2] described a Finnish sibship with normal parents and 12 members.
Stephanie Lateo +4 more
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Journal of Cell Science, 2001
Plectin is a major component of the cytoskeleton and is expressed in a wide variety of cell types. It plays an important role in the integrity of the cytoskeleton by cross-linking the three filamentous networks and stabilizing cell-matrix and cell-cell contacts.
Fontao, L +5 more
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Plectin is a major component of the cytoskeleton and is expressed in a wide variety of cell types. It plays an important role in the integrity of the cytoskeleton by cross-linking the three filamentous networks and stabilizing cell-matrix and cell-cell contacts.
Fontao, L +5 more
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Purification and Structural Analysis of Plectin and BPAG1e
2016Plectin and BPAG1e belong to the plakin family of high-molecular-weight proteins that interconnect the cytoskeletal systems and anchor them to junctional complexes. Plectin and BPAG1e are prototypical plakins with a similar tripartite modular structure.
José A, Manso +8 more
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Networking and anchoring through plectin: a key to IF functionality and mechanotransduction
Current Opinion in Cell Biology, 2015Intermediate filaments (IFs) are involved in multiple cellular processes that are essential for the maintenance of cell and tissue integrity as well as response and adaption to stress. Mainly through pathological manifestations in patients and the analysis of genetic mouse models, it became evident that cytolinker proteins of the plakin protein family ...
Gerhard Wiche +2 more
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Domain Structure and Transcript Diversity of Plectin
The Biological Bulletin, 1998Plectin, a cytoskeleton-associated protein of exceptionally large size, is abundantly expressed in a wide variety of mammalian tissues and cell types. It is codistributed with different types of intermediate filaments (IFs) and is prominently located at the plasma membrane attachment sites of IFs and of microfilaments, such as hemidesmosomes (Wiche et ...
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