Results 91 to 100 of about 4,450 (185)

Additional file 1 of Plectin promotes tumor formation by B16 mouse melanoma cells via regulation of Rous sarcoma oncogene activity

, 2022
Additional file 1: Fig S1. Generation of plectin knockdown human melanoma cells. Fig S2. Tumor weights and volumes. Fig S3. Cell proliferation is decreased in plectin knockdown human melanoma cells. Fig S4.
Yukiyo Tada-Shigeyama (13524196), William N. Addison (13524193), Akino Goto (13524190), Hiromi Honda (3112164), Tatsuki Yaginuma (13524199), Kou Matsuo (361983), Shoichiro Kokabu (381370), Kana Mizuta (13524184), Takuma Matsubara (13524187), Mitsushiro Nakatomi (3180675), Izumi Yoshioka (5488274)   +10 more
core   +1 more source

Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms [PDF]

, 2008
Dysfunction of plectin, a 500-kD cytolinker protein, leads to skin blistering and muscular dystrophy. Using conditional gene targeting in mice, we show that plectin deficiency results in progressive degenerative alterations in striated muscle, including ...
Kunz, Wolfram S (Rheinische Friedrich-Wilhelms Universität Bonn), Wiche, Gerhard (University of Vienna), Denise Paulin, Irmgard Fischer, Konieczny, Patryk (University of Vienna), Wolfram S. Kunz, Anikó Zeöld, Fischer, Irmgard (University of Vienna), Siegfried Reipert, Schröder, Rolf (Universität Köln), Paulin, Denise J. (University of Vienna), Zeöld, Aniko (Department of Computational Biological Chemistry, Faculty of Chemistry, University of Vienna), Peter Fuchs, Reipert, Siegfried (University of Vienna), Rolf Schröder, Gerhard Wiche, Fuchs, Peter (University of Vienna), Patryk Konieczny   +17 more
core   +1 more source

Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation

Cells
In muscle cells subjected to mechanical stimulation, LINC complex and cytoskeletal proteins are basic to preserve cellular architecture and maintain nuclei orientation and positioning. In this context, the role of lamin A/C remains mostly elusive.
Vittoria Cenni, Camilla Evangelisti, Spartaco Santi, Patrizia Sabatelli, Simona Neri, Marco Cavallo, Giovanna Lattanzi, Elisabetta Mattioli   +7 more
doaj   +1 more source

Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation

Biology Open, 2016
The Deleted in liver cancer 1 (Dlc1) gene codes for a Rho GTPase-activating protein that also acts as a tumour suppressor gene. Several studies have consistently found that overexpression leads to excessive cell elongation, cytoskeleton changes and ...
Mohammad G. Sabbir, Rachelle Dillon, Michael R. A. Mowat   +2 more
doaj   +1 more source

Expanding the Clinical Phenotype of PLECTIN-Related Plectinopathies

Iranian Journal of Public Health
Background: Plectinopathy-associated disorders are caused by mutations in the PLECTIN (PLEC) gene encoding Plectin protein. PLEC mutations cause a spectrum of diseases defined by varying degrees of signs, mostly with epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) and plectinopathy-related disorder is limb-girdle muscular dystrophy type ...
Torbati, Paria Najarzadeh, Doosti, Mohammad, Sarraf, Payam, Boostani, Reza, Ahangari, Najmeh, Toosi, Mehran Beiraghi, Tafakhori, Abbas, Babaei, Meisam, Abedini, Soheila, Malek, Hadis, Maskani, Samaneh, Safi, Mojtaba, Karimiani, Ehsan Ghayoor   +12 more
openaire   +2 more sources

Plectin-1 targeted AAV vector for the molecular imaging of pancreatic cancer

Frontiers in Oncology, 2013
Pancreatic ductal adenocarcinoma (PDAC) is highly malignant disease that is the 4th leading cause of cancer-related death in the US. Gene therapy using AAV vectors to selectively deliver genes to PDAC cells is an attractive treatment option for ...
Prasad R. Konkalmatt, Defeng eDeng, Stephanie eThomas, Michael T. Wu, Craig D. Logsdon, Brent A. French, Kimberly A Kelly   +6 more
doaj   +1 more source

The rod domain is not essential for the function of plectin in maintaining tissue integrity

, 2016
This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.-- et
Ketema, Mirjam, Pereda, José M. de, Sonnenberg, Arnoud   +2 more
core   +1 more source

Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres

, 2006
Plectin, a cytolinker protein greater than 500 kDa in size, has an important role as a mechanical stabiliser of cells. It interlinks the various cytoskeletal filament systems and anchors intermediate filaments to peripheral junctional complexes.
Oehler, Susanne (Universität Wien), Gregor, Martin (University of Vienna), Wiche, Gerhard (University of Vienna), Zeoeld, Aniko (University of Vienna), Fuchs, Peter (University of Vienna), Andrä Marobela, Kerstin (Universität Wien), Hardie, David Grahame (University of Dundee), Weigel, Günter (Medizinische Universität Wien)   +7 more
core   +1 more source

The Role of Plectin in Pancreatic Cancer [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is an intractable clinical problem. It is the fourth leading cause of cancer deaths in the United States and the five-year survival rate of PDAC is only 6%. The prognosis remains poor due to its highly aggressive nature and resistance to extant therapies.
openaire   +1 more source

Inflammatory epidermolysis bullosa acquisita with coexistent IgA antibodies to plectin

, 2005
We present a case of inflammatory epidermolysis bullosa acquisita (EBA) with IgA antibodies to plectin. Analysis of lesional skin biopsies by electron microscopy revealed the split level to be in the sublamina densa zone, corresponding to the diagnosis ...
Buijsrogge, JJA, Meijer, HJ, Dijk, F, Pas, HH, de Jong, MCJM, Jonkman, MF   +5 more
core   +1 more source