Results 71 to 80 of about 4,450 (185)

Immunoblots detect efficient reduction of plectin and complex alterations of integrin expression in A431 clones stably transfected with plectin shRNAs.

, 2016
Complete cell lysates were obtained from AK13-1-derived subclones that were either stably transfected with scramble shRNA (controls) or plectin shRNA (shPlectin). For comparison, cell lysates from non-transfected A431 cells were prepared.
Fabian Herb (2579410), Kraisorn Chaisaowong (2579407), Rudolf E. Leube (132404), Marcin Moch (2579392), Andreas Omenzetter (2579401), Reinhard Windoffer (132400), Lena Ramms (2579404), Uwe Schnakenberg (2579395), Raphaela Pohl (2579398), Nicole Schwarz (313667), Bernd Hoffmann (191620), Rudolf Merkel (191622), Gloria Fabris (837999), Dorit Merhof (290212)   +13 more
core   +1 more source

Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases

MedComm, Volume 7, Issue 3, March 2026.
This study examined hemidesmosome assembly‐related genes in pemphigoid diseases, revealing variants linked to disease onset and severity. Functional analyses, including Caenorhabditis elegans models, Ker‐CT transcriptomics, human proteomics, etc., demonstrated that ITGA6 mutations destabilize hemidesmosomes, disrupt dermal–epidermal adhesion, and ...
Shan Cao, Tianyu Wang, Chen Lv, Shanshan Ma, Gongqi Yu, Qianqian Xia, Tingting Liu, Yueqian Yu, Lele Sun, Xiaoyan Pei, Qing Zhao, Zhenzhen Wang, Chuan Wang, Yongxia Liu, Shengli Chen, Jianwen Wang, Guizhi Zhou, Hong Liu, Yonghu Sun, Furen Zhang   +19 more
wiley   +1 more source

Critical role of plectin in anti-migration potential of curcumin

, 2018
Plectin, a linker protein that organizes the cytoskeleton, is critical for cell migration and wound healing. It is specifically expressed in epithelial cells, muscles, and other tissues.
YOUNG RAN HA, Lee, SJ, Choi, YW
core   +1 more source

Bioelectronic Technology for Nutritional Research—a Novel In Vitro Platform for a Better Understanding of Human Gut Barrier Absorption

Advanced Biology, Volume 10, Issue 2, February 2026.
This is the first study to demonstrate that the e‐transmembrane gut model provides more accurate physiological predictions than conventional cell culture inserts when tested by the dietary compound butyrate. The bioelectronic e‐transmembrane platform integrates technological and biological optimizations, enabling the hosting of a complex human gut in ...
Verena Stoeger, Magdalena Strauss, Kumar Thurimella, Shani Elias‐Kirma, Izabella Niewczas, Etkin Parlar, Erika Schaudy, Chrysanthi‐Maria Moysidou, Stephen Voong, Jory Lietard, Jonathan Clark, Christopher Gerner, Róisín M. Owens   +12 more
wiley   +1 more source

Plectin deficiency results in muscular dystrophy with epidermolysis bullosa

, 1996
We report that mutation in the gene for plectin, a cytoskeleton-membrane anchorage protein, is a cause of autosomal recessive muscular dystrophy associated with skin blistering (epidermolysis bullosa simplex).
Leigh, I.M., Geddes, J.F., Pulkkinen, L., Kelsell, D.P., G. Milana, L. Pulkkinen, D.P. Kelsell, W.H.I. McLean, A.G. de Bono, Bryant, S.P., J.R. McMillan, J. Uitto, Smith, F.J.D., Kirtschig, G., Uitto, J., Milana, G., McMillan, J.R., Rugg, E.L., Wiche, G., J.F. Geddes, K. Owaribe, Eady, R.A.J., E.L. Rugg, S.P. Bryant, G. Kirtschig, De Bono, A.G., I.M. Leigh, Spurr, N.K., F.J.D. Smith, McLean, W.H.I., Owaribe, K., R.A.J. Eady, G. Wiche, E.B. Lane, Lane, E.B., N.K. Spurr   +35 more
core   +1 more source

No major role for rare plectin variants in arrhythmogenic right ventricular cardiomyopathy.

PLoS ONE, 2018
AimsLikely pathogenic/pathogenic variants in genes encoding desmosomal proteins play an important role in the pathophysiology of arrhythmogenic right ventricular cardiomyopathy (ARVC).
Edgar T Hoorntje, Anna Posafalvi, Petros Syrris, K Joeri van der Velde, Marieke C Bolling, Alexandros Protonotarios, Ludolf G Boven, Nuria Amat-Codina, Judith A Groeneweg, Arthur A Wilde, Nara Sobreira, Hugh Calkins, Richard N W Hauer, Marcel F Jonkman, William J McKenna, Perry M Elliott, Richard J Sinke, Maarten P van den Berg, Stephen P Chelko, Cynthia A James, J Peter van Tintelen, Daniel P Judge, Jan D H Jongbloed   +22 more
doaj   +1 more source

Dynamic alteration of poroelastic attributes as determinant membrane nanorheology for endocytosis of organ specific targeted gold nanoparticles

Journal of Nanobiotechnology, 2022
Background Efficacy of targeted drug delivery using nanoparticles relies on several factors including the uptake mechanisms such as phagocytosis, macropinocytosis, micropinocytosis and receptor mediated endocytosis.
Tanmay Kulkarni, Debabrata Mukhopadhyay, Santanu Bhattacharya   +2 more
doaj   +1 more source

Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley   +1 more source

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

Cell Reports, 2015
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive.
Yaming Jiu, Jaakko Lehtimäki, Sari Tojkander, Fang Cheng, Harri Jäälinoja, Xiaonan Liu, Markku Varjosalo, John E. Eriksson, Pekka Lappalainen   +8 more
doaj   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 5-25, January 2026.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source