Results 71 to 80 of about 3,850 (157)
Molecular Oncology, Volume 20, Issue 6, Page 1383-1384, June 2026.Cover To reduce the global disease burden more effectively, cancer interception should be established as a fundamental pillar of oncology, integrated with prevention, early detection and therapeutic management. Read the full EACR Viewpoint article by Charlotte Grieco, Tej Pandya and Charles Swanton on conceptual frameworks for cancer prevention through
wiley +1 more source
PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736.
PLoS ONE, 2015 The integrin α6β4, a major component of hemidesmosomes (HDs), stabilizes keratinocyte cell adhesion to the epidermal basement membrane through binding to the cytoskeletal linker protein plectin and association with keratin filaments.
Lisa Te Molder, Arnoud Sonnenberg
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Plectin contributes to mechanical properties of living cells
American Journal of Physiology-Cell Physiology, 2009 Plectin is a 500-kDa cross-linking protein that plays important roles in a number of cell functions including migration and wound healing. We set out to characterize the role of plectin in mechanical properties of living cells. Plectin−/− cells were less stiff than plectin+/+ cells, but the slopes of the two power laws in response to loading ...
Na, Sungsoo +7 more
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The Role of Plectin in Pancreatic Cancer [PDF]
, 2017 Pancreatic ductal adenocarcinoma (PDAC) is an intractable clinical problem. It is the fourth leading cause of cancer deaths in the United States and the five-year survival rate of PDAC is only 6%. The prognosis remains poor due to its highly aggressive nature and resistance to extant therapies.
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CellsIn muscle cells subjected to mechanical stimulation, LINC complex and cytoskeletal proteins are basic to preserve cellular architecture and maintain nuclei orientation and positioning. In this context, the role of lamin A/C remains mostly elusive.
Vittoria Cenni +7 more
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Plectin-1 targeted AAV vector for the molecular imaging of pancreatic cancer
Frontiers in Oncology, 2013 Pancreatic ductal adenocarcinoma (PDAC) is highly malignant disease that is the 4th leading cause of cancer-related death in the US. Gene therapy using AAV vectors to selectively deliver genes to PDAC cells is an attractive treatment option for ...
Prasad R. Konkalmatt +6 more
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Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation
Biology Open, 2016 The Deleted in liver cancer 1 (Dlc1) gene codes for a Rho GTPase-activating protein that also acts as a tumour suppressor gene. Several studies have consistently found that overexpression leads to excessive cell elongation, cytoskeleton changes and ...
Mohammad G. Sabbir +2 more
doaj +1 more source
Reconstitution of cytolinker-mediated crosstalk between actin and vimentin
European Journal of Cell BiologyCell shape and motility are determined by the cytoskeleton, an interpenetrating network of actin filaments, microtubules, and intermediate filaments. The biophysical properties of each filament type individually have been studied extensively by cell-free
Irene Istúriz Petitjean +6 more
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Filamin A in the ovary: a mediator of granulosa cell functions
Reproduction and FertilityFilamin A (FLNA) regulates the mechanical properties and shape of cells by cross-linking actin filaments orthogonally. It also serves as a scaffold for numerous interacting proteins, thereby coordinating cell differentiation and morphogenesis.
Yuhao Jiang +9 more
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