Results 61 to 70 of about 7,348 (200)

Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε [PDF]

, 2011
Background Inactivating mutations of SMAD4 are frequent in metastatic colorectal carcinomas. In previous analyses, we were able to show that restoration of Smad4 expression in Smad4-deficient SW480 human colon carcinoma cells was adequate to ...
Sven-T Liffers, Abdelouahid Maghnouj, Johanna B Munding, René Jackstadt, Ulrike Herbrand, Thomas Schulenborg, Katrin Marcus, Susanne Klein-Scory, Wolff Schmiegel, Irmgard Schwarte-Waldhoff, Helmut E Meyer, Kai Stühler, Stephan A Hahn   +12 more
core   +1 more source

Purification and Structural Analysis of Plectin and BPAG1e

, 2016
Plectin and BPAG1e belong to the plakin family of high-molecular-weight proteins that interconnect the cytoskeletal systems and anchor them to junctional complexes. Plectin and BPAG1e are prototypical plakins with a similar tripartite modular structure.
Manso, José A., García-Rubio, Inés, Gómez-Hernández, María, Ortega, Esther, Martínez Buey, Rubén, Carballido Vázquez, Ana M., Carabias, Arturo, Alonso-García, Noelia, Pereda, José M. de   +8 more
openaire   +3 more sources

Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding [PDF]

The Journal of Cell Biology, 1999
Hemidesmosomes are stable adhesion complexes in basal epithelial cells that provide a link between the intermediate filament network and the extracellular matrix. We have investigated the recruitment of plectin into hemidesmosomes by the α6β4 integrin and have shown that the cytoplasmic domain of the β4 subunit associates with an NH2-terminal fragment ...
Geerts, Dirk, Fontao, Lionel, Nievers, Mirjam G., Schaapveld, Roel Q., Purkis, Patricia E., Wheeler, Grant N, Lane, E. Birgitte, Leigh, Irene M., Sonnenberg, Arnoud   +8 more
openaire   +3 more sources

The RhoA guanine exchange factor ABR: a glucose‐sensitive mediator of actin reorganization in feto‐placental arterial endothelial cells altered by gestational diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic, Boris Novakovic, Barbara Leopold‐Posch, Magdalena Mühlberger, Denise Hoch, Jelena Lögl, Eva M. Bernhart, Richard Saffery, Gernot Desoye, Ursula Hiden   +9 more
wiley   +1 more source

Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. [PDF]

PLoS ONE, 2013
Prostate cancer is a clinically heterogeneous disease, ranging from indolent asymptomatic disease to very aggressive metastatic and life threatening forms of the disease. Distant metastasis represents the major lethal cause of prostate cancer.
Tanya C Burch, Megan T Watson, Julius O Nyalwidhe   +2 more
doaj   +1 more source

Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice

EBioMedicine, 2022
Summary: Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high
Wenjia Zhang, Xiaolong Liang, Liang Zhu, Xinyu Zhang, Zhengyu Jin, Yang Du, Jie Tian, Huadan Xue   +7 more
doaj   +1 more source

The atomic structure of human dystrophin spectrin‐like repeat 24

Acta Crystallographica Section F, Volume 82, Issue 5, Page 184-193, May 2026.
The atomic structure of human dystrophin spectrin‐like repeat 24 was determined at 2.14 Å resolution.The structure of spectrin‐like repeat 24 of human dystrophin was determined at 2.5 Å effective resolution. The structure exhibits a three‐helix bundle fold, common to all spectrin‐repeat family members, and shares a high degree of homology with existing
Oakley Streeter, Ke Shi, Hannah Bui, Hideki Aihara, James M. Ervasti, Robert Evans III, Joseph M. Muretta   +6 more
wiley   +1 more source

Consequences of plectin ablation on the various intermediate filament systems in skeletal muscle

European Journal of Cell Biology
Plectin, a highly versatile and multifunctional cytolinker, acts as a central connector of the intermediate filament (IF) and other cytoskeletal systems.
Marta Rocha, Jonas Petsch, Dorothea Schultheis, Michaela M. Zrelski, Petra Fichtinger, Inga Koneczny, Samuel Meier-Menches, Gerhard Wiche, Rolf Schröder, Lilli Winter   +9 more
doaj   +1 more source

Drosophila Short stop as a paradigm for the role and regulation of spectraplakins [PDF]

, 2017
Spectraplakins are evolutionarily well conserved cytoskeletal linker molecules that are true members of three protein families: plakins, spectrins and Gas2-like proteins.
Hahn, Ines, Liew, Yu-Ting, Melero, Cristina, Prokop, Andreas, Qu, Yue, Sanchez-Soriano, Natalia, Voelzmann, Andre   +6 more
core   +2 more sources

MACF1 gene structure: a hybrid of plectin and dystrophin [PDF]

Mammalian Genome, 2001
Mammalian MACF1 (Macrophin1; previously named ACF7) is a giant cytoskeletal linker protein with three known isoforms that arise by alternative splicing. We isolated a 19.1-kb cDNA encoding a fourth isoform (MACF1-4) with a unique N-terminus. Instead of an N-terminal actin-binding domain found in the other three isoforms, MACF1-4 has eight plectin ...
Gong, Tzy-Wen L., Besirli, Cagri G., Lomax, Margaret I.   +2 more
openaire   +3 more sources