Results 61 to 70 of about 3,850 (157)

No major role for rare plectin variants in arrhythmogenic right ventricular cardiomyopathy.

PLoS ONE, 2018
AimsLikely pathogenic/pathogenic variants in genes encoding desmosomal proteins play an important role in the pathophysiology of arrhythmogenic right ventricular cardiomyopathy (ARVC).
Edgar T Hoorntje, Anna Posafalvi, Petros Syrris, K Joeri van der Velde, Marieke C Bolling, Alexandros Protonotarios, Ludolf G Boven, Nuria Amat-Codina, Judith A Groeneweg, Arthur A Wilde, Nara Sobreira, Hugh Calkins, Richard N W Hauer, Marcel F Jonkman, William J McKenna, Perry M Elliott, Richard J Sinke, Maarten P van den Berg, Stephen P Chelko, Cynthia A James, J Peter van Tintelen, Daniel P Judge, Jan D H Jongbloed   +22 more
doaj   +1 more source

Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub

Ecology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno, Jonas Grossmann, Laura Kunz, Antje Dittmann, Vitor C. Sousa, Romana Santos   +5 more
wiley   +1 more source

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

Cell Reports, 2015
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive.
Yaming Jiu, Jaakko Lehtimäki, Sari Tojkander, Fang Cheng, Harri Jäälinoja, Xiaonan Liu, Markku Varjosalo, John E. Eriksson, Pekka Lappalainen   +8 more
doaj   +1 more source

Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases

MedComm, Volume 7, Issue 3, March 2026.
This study examined hemidesmosome assembly‐related genes in pemphigoid diseases, revealing variants linked to disease onset and severity. Functional analyses, including Caenorhabditis elegans models, Ker‐CT transcriptomics, human proteomics, etc., demonstrated that ITGA6 mutations destabilize hemidesmosomes, disrupt dermal–epidermal adhesion, and ...
Shan Cao, Tianyu Wang, Chen Lv, Shanshan Ma, Gongqi Yu, Qianqian Xia, Tingting Liu, Yueqian Yu, Lele Sun, Xiaoyan Pei, Qing Zhao, Zhenzhen Wang, Chuan Wang, Yongxia Liu, Shengli Chen, Jianwen Wang, Guizhi Zhou, Hong Liu, Yonghu Sun, Furen Zhang   +19 more
wiley   +1 more source

Bioelectronic Technology for Nutritional Research—a Novel In Vitro Platform for a Better Understanding of Human Gut Barrier Absorption

Advanced Biology, Volume 10, Issue 2, February 2026.
This is the first study to demonstrate that the e‐transmembrane gut model provides more accurate physiological predictions than conventional cell culture inserts when tested by the dietary compound butyrate. The bioelectronic e‐transmembrane platform integrates technological and biological optimizations, enabling the hosting of a complex human gut in ...
Verena Stoeger, Magdalena Strauss, Kumar Thurimella, Shani Elias‐Kirma, Izabella Niewczas, Etkin Parlar, Erika Schaudy, Chrysanthi‐Maria Moysidou, Stephen Voong, Jory Lietard, Jonathan Clark, Christopher Gerner, Róisín M. Owens   +12 more
wiley   +1 more source

Plectin is a regulator of prostate cancer growth and metastasis

Oncogene, 2020
Prostate cancer is responsible for over 30,000 US deaths annually, attributed largely to incurable metastatic disease. Here, we demonstrate that high levels of plectin are associated with localized and metastatic human prostate cancer when compared to benign prostate tissues.
Mark Buckup, Meghan A. Rice, En-Chi Hsu, Fernando Garcia-Marques, Shiqin Liu, Merve Aslan, Abel Bermudez, Jiaoti Huang, Sharon J. Pitteri, Tanya Stoyanova   +9 more
openaire   +3 more sources

Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley   +1 more source

Plectin Missense Mutation p.Leu319Pro in the Pathogenesis of Autosomal Recessive Epidermolysis Bullosa Simplex

Acta Dermato-Venereologica, 2020
is missing (Short communication)
Wei-Ting Tu, Peng-Chieh Chen, Ping-Chen Hou, Hsin-Yu Huang, Jing-Yu Wang, Sheau-Chiou Chao, Julia Yu-Yun Lee, John A. McGrath, Ken Natsuga, Chao-Kai Hsu   +9 more
doaj   +1 more source

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

Frontiers in Immunology
BackgroundPancreatic adenocarcinoma (PDAC) is an abysmal disease with poor clinical outcomes, largely due to limited life-extending treatments. Notably, PDAC displays a T cell-suppressive tumor microenvironment, and the underlying molecular mechanisms ...
Cody L. Wolf, Roxanne K. Ruiz, Roxanne K. Ruiz, Sokchea Khou, Robert Cornelison, Edward B. Stelow, Karl M. Kowalewski, Matthew J. Lazzara, Matthew J. Lazzara, Amanda Poissonnier, Lisa M. Coussens, Lisa M. Coussens, Kimberly A. Kelly, Kimberly A. Kelly   +13 more
doaj   +1 more source

Epidermolysis bullosa simplex: genotype-phenotype correlations

Vestnik Dermatologii i Venerologii
Epidermolysis bullosa simplex (EBS) includes a group of diseases characterized by varying severity, possible damage to visceral organs, and various outcomes ranging from complete regression of the rash to death. The initial clinical manifestations of EBS
Vadim V. Chikin, Arfenia E. Karamova
doaj   +1 more source