Results 41 to 50 of about 951 (141)

Immunofluorescence microscopy shows efficient down regulation of plectin in stably transfected A431 clones producing plectin shRNA.

, 2016
The fluorescence images (maximum intensity projections of complete cells) were recorded in AK13-1 subclones stably expressing HK13-EGFP and either scramble control shRNAs or plectin shRNAs.
Fabian Herb (2579410), Kraisorn Chaisaowong (2579407), Rudolf E. Leube (132404), Marcin Moch (2579392), Andreas Omenzetter (2579401), Reinhard Windoffer (132400), Lena Ramms (2579404), Uwe Schnakenberg (2579395), Raphaela Pohl (2579398), Nicole Schwarz (313667), Bernd Hoffmann (191620), Rudolf Merkel (191622), Gloria Fabris (837999), Dorit Merhof (290212)   +13 more
core   +1 more source

Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma

Journal of Biomedical Science
Background The expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression of the major IF-based cytolinker, plectin (PLEC), and its contribution to GBM migration and ...
Maja Žugec, Borut Furlani, Maria J. Castañon, Boštjan Rituper, Irmgard Fischer, Giuseppe Broggi, Rosario Caltabiano, Giuseppe M. V. Barbagallo, Michelino Di Rosa, Daniele Tibullo, Rosalba Parenti, Nunzio Vicario, Saša Simčič, Victorio Martin Pozo Devoto, Gorazd B. Stokin, Gerhard Wiche, Jernej Jorgačevski, Robert Zorec, Maja Potokar   +18 more
doaj   +1 more source

Sustained Activation of CaMKII Promotes Skeletal Muscle Contractile Dysfunction in Aging

Aging Cell, Volume 25, Issue 9, September 2026.
CaMKII exemplifies antagonistic pleiotropy in skeletal muscle. Exercise‐related Ca2+/redox signals drive transient CaMKII activation supporting youthful performance. Here we show CaMKII is upregulated in aged muscle, where dysregulated Ca2+/redox signals likely sustain its activity; constitutively active CaMKII recapitulates aging‐associated ...
Michael R. Bene, Tae Chung, Elizabeth D. Luczak, Gabriel Lopez‐Cecetaite, William A. Fountain, Giovanni Rosales‐Soto, Erick Hernández‐Ochoa, Corina Antonescu, Liliana Florea, Seeun J. Jeong, Emily Elassal, Anne Le, Qian‐Li Xue, Ahmet Hoke, Peter M. Abadir, Qinchuan Wang   +15 more
wiley   +1 more source

High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis

BMC Biology
Background Abundant research indicates that increased extracellular matrix (ECM) stiffness significantly enhances the malignant characteristics of hepatocellular carcinoma (HCC) cells.
Zhihui Wang, Wenbin Wang, Qing Luo, Guanbin Song   +3 more
doaj   +1 more source

Consequences of plectin ablation on the various intermediate filament systems in skeletal muscle

European Journal of Cell Biology
Plectin, a highly versatile and multifunctional cytolinker, acts as a central connector of the intermediate filament (IF) and other cytoskeletal systems.
Marta Rocha, Jonas Petsch, Dorothea Schultheis, Michaela M. Zrelski, Petra Fichtinger, Inga Koneczny, Samuel Meier-Menches, Gerhard Wiche, Rolf Schröder, Lilli Winter   +9 more
doaj   +1 more source

Caspase‐mediated cleavage events hidden by secondary proteolysis during apoptosis

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Caspases are cysteine proteases that cleave specific proteins to control a range of cellular processes including cell death, inflammation, and differentiation. Proteomic approaches, like N‐terminomics, have been central to identifying both cleaved proteins and where they are cleaved.
Fatemeh Fotouhi, Erik Gomez‐Cardona, Jainilkumar Patel, Olivier Julien, Howard Fearnhead   +4 more
wiley   +1 more source

MACF1 gene structure: a hybrid of plectin and dystrophin [PDF]

Mammalian Genome, 2001
Mammalian MACF1 (Macrophin1; previously named ACF7) is a giant cytoskeletal linker protein with three known isoforms that arise by alternative splicing. We isolated a 19.1-kb cDNA encoding a fourth isoform (MACF1-4) with a unique N-terminus. Instead of an N-terminal actin-binding domain found in the other three isoforms, MACF1-4 has eight plectin ...
Gong, Tzy-Wen L., Besirli, Cagri G., Lomax, Margaret I.   +2 more
openaire   +3 more sources

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, Volume 4, Issue 3, August 2026.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Plectin-1 as a Novel Biomarker for Pancreatic Cancer [PDF]

Clinical Cancer Research, 2011
Abstract Purpose: We are in great need of specific biomarkers to detect pancreatic ductal adenocarcinoma (PDAC) at an early stage, ideally before invasion. Plectin-1 (Plec1) was recently identified as one such biomarker. However, its suitability as a specific biomarker for human pancreatic cancer, and its usability as an imaging ...
Bausch, Dirk, Thomas, Stephanie, Mino-Kenudson, Mari, Fernandez-del-Castillo, Carlos, Bauer, T. W., Williams, M., Warshaw, Andrew Louis, Thayer, Sarah P., Kelly, Kimberly A.   +8 more
openaire   +3 more sources

Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. [PDF]

PLoS ONE, 2013
Prostate cancer is a clinically heterogeneous disease, ranging from indolent asymptomatic disease to very aggressive metastatic and life threatening forms of the disease. Distant metastasis represents the major lethal cause of prostate cancer.
Tanya C Burch, Megan T Watson, Julius O Nyalwidhe   +2 more
doaj   +1 more source