Results 41 to 50 of about 7,348 (200)

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse [PDF]

open access: yes, 2012
Loss of dystrophin protein due to mutations in the DMD gene causes Duchenne muscular dystrophy. Dystrophin loss also leads to the loss of the dystrophin glycoprotein complex (DGC) from the sarcolemma which contributes to the dystrophic phenotype ...
Andrew Mitchell   +55 more
core   +2 more sources

Antibody Characterization Report for Plectin

open access: yes, 2021
Head to head comparison of available commercial antibodies against Plectin by immunoblot (Western blot), immunoprecipitation and immunofluorescence.
Ayoubi, Riham   +3 more
openaire   +4 more sources

A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer

open access: yesCells, 2021
Cancer-specific plectin (CSP) is a pro-tumorigenic protein selectively expressed on the cell surface of major cancers, including ovarian cancer (OC). Despite its assessable localization, abundance, and functional significance, the therapeutic efficacy of
Samantha M. Perez   +3 more
doaj   +1 more source

The 'Spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families [PDF]

open access: yes, 2002
Recent studies have characterised a family of giant cytoskeletal crosslinkers encoded by the short stop gene in Drosophila and the dystonin/BPAG1 and MACF1 genes in mammals.
Brown, N., Gregory, S., Roeper, K.
core   +2 more sources

Detection of Circulating Tumor Cells in Resectable Pancreatic Ductal Adenocarcinoma: A Prospective Evaluation as a Prognostic Marker

open access: yesFrontiers in Oncology, 2021
Circulating tumor cells (CTCs) are useful biomarkers of many solid tumors, but are infrequently detected in early stage pancreatic ductal adenocarcinomas (PDACs). The first drainage of pancreatic venous blood flow come to portal vein and pass through the
Byeong Geun Song   +15 more
doaj   +1 more source

Molecular architecture and function of the hemidesmosome [PDF]

open access: yes, 2015
Hemidesmosomes are multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane. The mechanical stability of hemidesmosomes relies on multiple interactions of a few protein components that form ...
Gerhard Wiche   +2 more
core   +3 more sources

Occurrence and immunolocalization of plectin in tissues. [PDF]

open access: yesThe Journal of cell biology, 1983
Various tissues from rat were examined for the occurrence and cellular localization of plectin, a 300,000-dalton polypeptide component present in intermediate filament-enriched cytoskeletons prepared from cultured cells by treatment with nonionic detergent and high salt solution.
G, Wiche   +4 more
openaire   +2 more sources

Proteome analysis of human serum proteins adsorbed onto different titanium surfaces used in dental implants [PDF]

open access: yes, 2016
Titanium dental implants are commonly used due to their biocompatibility and biochemical properties; blasted acid-etched Ti is used more frequently than smooth Ti surfaces.
Azkargorta, Mikel   +10 more
core   +2 more sources

Multigene Next-Generation Sequencing Panel Identifies Pathogenic Variants in Patients with Unknown Subtype of Epidermolysis Bullosa: Subclassification with Prognostic Implications [PDF]

open access: yes, 2017
Purpose: Epidermolysis bullosa (EB), the prototype of heritable blistering diseases, is caused by mutations in as many as 19 distinct genes. In this study, we evaluated the molecular basis of EB in 93 families, many of them of unknown subtype. Methods:
Abiri, Maryam   +15 more
core   +1 more source

Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells

open access: yesCells, 2020
Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology and pathophysiology. The cytoskeleton (microtubules, intermediate filaments,
Andrey V. Kuznetsov   +5 more
doaj   +1 more source

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