Results 41 to 50 of about 3,850 (157)

Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding [PDF]

The Journal of Cell Biology, 1999
Hemidesmosomes are stable adhesion complexes in basal epithelial cells that provide a link between the intermediate filament network and the extracellular matrix. We have investigated the recruitment of plectin into hemidesmosomes by the α6β4 integrin and have shown that the cytoplasmic domain of the β4 subunit associates with an NH2-terminal fragment ...
Geerts, Dirk, Fontao, Lionel, Nievers, Mirjam G., Schaapveld, Roel Q., Purkis, Patricia E., Wheeler, Grant N, Lane, E. Birgitte, Leigh, Irene M., Sonnenberg, Arnoud   +8 more
openaire   +3 more sources

Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia

Oral Diseases, EarlyView.
ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio, Divya Ganesh, Bishwa Prakash Bhattarai, Tine Merete Søland, Jonas Sundberg, Annika Thorsell, Jenny Öhman, Dipak Sapkota, Bengt Hasséus   +8 more
wiley   +1 more source

Caspase‐mediated cleavage events hidden by secondary proteolysis during apoptosis

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Caspases are cysteine proteases that cleave specific proteins to control a range of cellular processes including cell death, inflammation, and differentiation. Proteomic approaches, like N‐terminomics, have been central to identifying both cleaved proteins and where they are cleaved.
Fatemeh Fotouhi, Erik Gomez‐Cardona, Jainilkumar Patel, Olivier Julien, Howard Fearnhead   +4 more
wiley   +1 more source

Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma

Journal of Biomedical Science
Background The expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression of the major IF-based cytolinker, plectin (PLEC), and its contribution to GBM migration and ...
Maja Žugec, Borut Furlani, Maria J. Castañon, Boštjan Rituper, Irmgard Fischer, Giuseppe Broggi, Rosario Caltabiano, Giuseppe M. V. Barbagallo, Michelino Di Rosa, Daniele Tibullo, Rosalba Parenti, Nunzio Vicario, Saša Simčič, Victorio Martin Pozo Devoto, Gorazd B. Stokin, Gerhard Wiche, Jernej Jorgačevski, Robert Zorec, Maja Potokar   +18 more
doaj   +1 more source

Consequences of plectin ablation on the various intermediate filament systems in skeletal muscle

European Journal of Cell Biology
Plectin, a highly versatile and multifunctional cytolinker, acts as a central connector of the intermediate filament (IF) and other cytoskeletal systems.
Marta Rocha, Jonas Petsch, Dorothea Schultheis, Michaela M. Zrelski, Petra Fichtinger, Inga Koneczny, Samuel Meier-Menches, Gerhard Wiche, Rolf Schröder, Lilli Winter   +9 more
doaj   +1 more source

MACF1 gene structure: a hybrid of plectin and dystrophin [PDF]

Mammalian Genome, 2001
Mammalian MACF1 (Macrophin1; previously named ACF7) is a giant cytoskeletal linker protein with three known isoforms that arise by alternative splicing. We isolated a 19.1-kb cDNA encoding a fourth isoform (MACF1-4) with a unique N-terminus. Instead of an N-terminal actin-binding domain found in the other three isoforms, MACF1-4 has eight plectin ...
Gong, Tzy-Wen L., Besirli, Cagri G., Lomax, Margaret I.   +2 more
openaire   +3 more sources

Hemidesmosomal Proteins in Oral Cancer Progression: An Immunohistochemical Study of Human and Mouse

Journal of Oral Pathology &Medicine, Volume 55, Issue 7, Page 822-836, August 2026.
ABSTRACT Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease pathogenesis remains limited.
Nikhil Mongia, Ali Ibrahim Mohammed, Michael McCullough, Rita Paolini, James A. Rickard, Massimo Mascolo, Silvia Varricchio, Lorraine A. O'Reilly, John Silke, Nicola Cirillo, Antonio Celentano   +10 more
wiley   +1 more source

Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. [PDF]

PLoS ONE, 2013
Prostate cancer is a clinically heterogeneous disease, ranging from indolent asymptomatic disease to very aggressive metastatic and life threatening forms of the disease. Distant metastasis represents the major lethal cause of prostate cancer.
Tanya C Burch, Megan T Watson, Julius O Nyalwidhe   +2 more
doaj   +1 more source

Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice

EBioMedicine, 2022
Summary: Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high
Wenjia Zhang, Xiaolong Liang, Liang Zhu, Xinyu Zhang, Zhengyu Jin, Yang Du, Jie Tian, Huadan Xue   +7 more
doaj   +1 more source

ECMO Support in Paraneoplastic Pemphigus With Respiratory Failure: A Case Report With Immune Cell Monitoring

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Paraneoplastic pemphigus (PNP) is a life‐threatening autoimmune blistering disease with a mortality rate of 70%–90%, driven largely by respiratory complications such as bronchiolitis obliterans. Managing respiratory failure in these patients remains exceptionally difficult.
Lu Li, Danxia Chen, Linzi Jin, Qinqin Shu, Juan He, Yan Li   +5 more
wiley   +1 more source