Results 41 to 50 of about 4,450 (185)

Phosphorylation of serine 4642 in the C-terminus of plectin by MNK2 and PKA modulates its interaction with intermediate filaments [PDF]

open access: yes, 2013
Plectin is a versatile cytolinker of the plakin family conferring cell resilience to mechanical stress in stratified epithelia and muscles. It acts as a critical organizer of the cytoskeletal system by tethering various intermediate filament (IF ...
Borradori, Luca   +8 more
core   +1 more source

Antibody Characterization Report for Plectin

open access: yes, 2021
Head to head comparison of available commercial antibodies against Plectin by immunoblot (Western blot), immunoprecipitation and immunofluorescence.
Ayoubi, Riham   +3 more
openaire   +4 more sources

The “Third Violin” in the Cytoskeleton Orchestra—The Role of Intermediate Filaments in the Endothelial Cell’s Life

open access: yesBiomedicines, 2022
The endothelium plays an important role in the transcytosis of lipoproteins. According to one of the theories, endothelial injury is a triggering factor for the development of atherosclerosis, and intracellular structures, including components of the ...
Anton S. Shakhov, Irina B. Alieva
doaj   +1 more source

A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer

open access: yesCells, 2021
Cancer-specific plectin (CSP) is a pro-tumorigenic protein selectively expressed on the cell surface of major cancers, including ovarian cancer (OC). Despite its assessable localization, abundance, and functional significance, the therapeutic efficacy of
Samantha M. Perez   +3 more
doaj   +1 more source

Occurrence and immunolocalization of plectin in tissues. [PDF]

open access: yesThe Journal of cell biology, 1983
Various tissues from rat were examined for the occurrence and cellular localization of plectin, a 300,000-dalton polypeptide component present in intermediate filament-enriched cytoskeletons prepared from cultured cells by treatment with nonionic detergent and high salt solution.
G, Wiche   +4 more
openaire   +2 more sources

Detection of Circulating Tumor Cells in Resectable Pancreatic Ductal Adenocarcinoma: A Prospective Evaluation as a Prognostic Marker

open access: yesFrontiers in Oncology, 2021
Circulating tumor cells (CTCs) are useful biomarkers of many solid tumors, but are infrequently detected in early stage pancreatic ductal adenocarcinomas (PDACs). The first drainage of pancreatic venous blood flow come to portal vein and pass through the
Byeong Geun Song   +15 more
doaj   +1 more source

Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells

open access: yesCells, 2020
Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology and pathophysiology. The cytoskeleton (microtubules, intermediate filaments,
Andrey V. Kuznetsov   +5 more
doaj   +1 more source

Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. [PDF]

open access: yesPLoS Medicine, 2008
BackgroundPancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies.
Kimberly A Kelly   +8 more
doaj   +1 more source

Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin

open access: yes, 1997
The cornified envelope is a layer of transglutaminase cross-linked protein that is assembled under the plasma membrane of keratinocytes in the outermost layers of the epidermis.
Christiana Ruhrberg   +7 more
core   +1 more source

β4 integrin is not essential for localization of hemidesmosome proteins plectin and CD151 in cerebral vessels

open access: yesBrain Circulation, 2016
Objective: In the central nervous system (CNS), β4 integrin is predominantly expressed by endothelial cells lining arterioles. As β4 integrin plays an essential role in epithelial tissues, organizing structural proteins into specialized adhesive ...
Jennifer V Welser-Alves   +3 more
doaj   +1 more source

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