Results 21 to 30 of about 4,450 (185)

Plectin contributes to mechanical properties of living cells

American Journal of Physiology-Cell Physiology, 2009
Plectin is a 500-kDa cross-linking protein that plays important roles in a number of cell functions including migration and wound healing. We set out to characterize the role of plectin in mechanical properties of living cells. Plectin−/− cells were less stiff than plectin+/+ cells, but the slopes of the two power laws in response to loading ...
Na, Sungsoo, Chowdhury, Farhan, Tay, Bernard, Ouyang, Mingxing, Gregor, Martin, Wang, Yingxiao, Wiche, Gerhard, Wang, Ning   +7 more
openaire   +5 more sources

Plectin (PLEC)-Related Intermediate Epidermolysis Bullosa Simplex without Extracutaneous Involvement with Response to Dapsone [PDF]

Indian Dermatology Online Journal
Plectinopathies, the spectrum of diseases caused by plectin gene (PLEC) mutations, have a wide range of manifestations, mostly extracutaneous, like pyloric atresia, muscular dystrophy, and cardiomyopathy, along with cutaneous tense blistering ...
Anisha Biswal, Bikash Ranjan Kar, Rahul Mahajan, Liza Mohapatra, Anoop Kumar   +4 more
doaj   +2 more sources

Plectin-vimentin interaction

, 2008
Das Cytolinkerprotein Plectin spielt bei der Aufrechterhaltung der Integrität des Zytoskeletts eine entscheidende Rolle, indem es Intermediärfilamente (IFs) mit anderen zytoskelettären Netzwerksystemen verbindet und diese an der Plasmamembran verankert. Weiters dient es als strukturelles Grundgerüst für Signalkaskaden und dürfte ebenfalls eine Funktion
Spurny, Radovan
openaire   +2 more sources

The interaction of plectin with actin: evidence for cross-linking of actin filaments by dimerization of the actin-binding domain of plectin

Journal of Cell Science, 2001
Plectin is a major component of the cytoskeleton and is expressed in a wide variety of cell types. It plays an important role in the integrity of the cytoskeleton by cross-linking the three filamentous networks and stabilizing cell-matrix and cell-cell contacts.
Fontao, L, Geerts, D, Kuikman, I, Koster, J, Kramer, D, Sonnenberg, A   +5 more
openaire   +3 more sources

MACF1 gene structure: a hybrid of plectin and dystrophin [PDF]

Mammalian Genome, 2001
Mammalian MACF1 (Macrophin1; previously named ACF7) is a giant cytoskeletal linker protein with three known isoforms that arise by alternative splicing. We isolated a 19.1-kb cDNA encoding a fourth isoform (MACF1-4) with a unique N-terminus. Instead of an N-terminal actin-binding domain found in the other three isoforms, MACF1-4 has eight plectin ...
Gong, Tzy-Wen L., Besirli, Cagri G., Lomax, Margaret I.   +2 more
openaire   +4 more sources

The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes [PDF]

Journal of Cell Science, 2015
ABSTRACT The transmission of mechanical forces to the nucleus is important for intracellular positioning, mitosis and cell motility, yet the contribution of specific components of the cytoskeleton to nuclear mechanotransduction remains unclear.
Almeida, FV, Walko, G, McMillan, JR, McGrath, JA, Wiche, G, Barber, AH, Connelly, JT   +6 more
openaire   +7 more sources

Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration [PDF]

Frontiers in Immunology
PurposeRegulation of inflammation and re-epithelialization are critical for efficient wound healing. This study explores the role of human α1-antitrypsin (hAAT), an immunomodulatory protein, in modulating inflammation and promoting re-epithelialization ...
Idan Farber, Idan Farber, Muhammad Wated, Ronen Schuster, Lihie Sheffer, Yuval Anav, Navit Ogen-Shtern, Navit Ogen-Shtern, Alexandra Tsitrina, Diya Tacruri, Anna Bunin, Noah Benjamin Nagar, Maayan Hagbi Bal, Tomer Eliyahu, Dor Halpern, Dor Halpern, Boris Knyazer, Samuel Cohen, Sabri El-Saied, Eli C. Lewis, Eldad Silberstein, Erez Tsumi   +21 more
doaj   +2 more sources

Molecular, structural, and in vivo analysis of the dominant plectin mutation plectin EBS-Ogna

, 2015
Plectin, ein großes multifunktionelles Cytoskelettprotein vernetzt Intermediärfilamente und vermittelt ihre Interaktion mit Aktinfilamenten und Mikrotubuli, den beiden anderen Cytoskelett-Filamentsystemen. Plectin verankert auch Intermediärfilamente an strategisch wichtigen Stellen der Zelle, wie Hemidesmosomen in basalen Keratinozyten, Costamere, Z ...
Jaksic, Nevena
openaire   +2 more sources

Plectin, an unusual target antigen in bullous pemphigoid

British Journal of Dermatology, 2001
Bullous pemphigoid (BP) is a blistering disease associated with autoantibodies directed against two components of hemidesmosomes, BP180 and BP230.To assess whether BP patients have autoantibodies targeting plectin, another hemidesmosomal component showing extensive homology to BP230.Examination of sera from 16 patients with BP, using ...
E, Laffitte, B, Favre, L, Fontao, S, Riou, F, Jaunin, K, Tamm, J H, Saurat, L, Borradori   +7 more
openaire   +3 more sources

Desmoplakin CSM models unravel mechanisms regulating the binding to intermediate filaments and putative therapeutics for cardiocutaneous diseases [PDF]

Scientific Reports
Arrhythmogenic cardiomyopathy (AC) is a common cause of sudden cardiac arrest and death in young adults. It can be induced by different types of mutations throughout the desmoplakin gene including the R2834H mutation in the extreme carboxyterminus tail ...
Cedric Badowski, Paula Benny, Chandra S. Verma, E. Birgitte Lane   +3 more
doaj   +2 more sources