Results 21 to 30 of about 7,348 (200)
Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer [PDF]
Cell & BioscienceBackground Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall
Lanning Bai +6 more
doaj +2 more sources
Filamin A in the ovary: a mediator of granulosa cell functions [PDF]
Reproduction and FertilityFilamin A (FLNA) regulates the mechanical properties and shape of cells by cross-linking actin filaments orthogonally. It also serves as a scaffold for numerous interacting proteins, thereby coordinating cell differentiation and morphogenesis.
Yuhao Jiang +9 more
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BMC Cancer, 2022 Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation ...
Kana Mizuta +10 more
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Identifying Plectin Isoform Functions through Animal Models
Cells, 2021 Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to intermediate filaments of all types and connects them to junctional complexes, organelles, and inner membrane systems.
Maria J. Castañón, Gerhard Wiche
doaj +1 more source
Cells, 2023 Plectin, a highly versatile cytolinker protein, is crucial for myofiber integrity and function. Accordingly, mutations in the human gene (PLEC) cause several rare diseases, denoted as plectinopathies, with most of them associated with progressive muscle ...
Lilli Winter +11 more
doaj +1 more source
Vimentin Intermediate Filaments: A Paradigm Shift From Static Structure to Dynamic Cytoplasmic Network [PDF]
BioessaysVimentin intermediate filaments form a dynamic, motile network that interacts with microfilaments and microtubules. We propose a hybrid transport model to explain vimentin filament dynamics through cytoskeletal crosstalk and organelle‐associated transport.
Renganathan B, Adam S, Gelfand V.
europepmc +2 more sources
Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. [PDF]
, 2013 Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and turnover of the extracellular matrix, metabolic processes that contribute to the mechanical properties of these cells.
Blanchette, Craig +5 more
core +9 more sources
GPR56/ADGRG1 regulates development and maintenance of peripheral myelin [PDF]
, 2018 Myelin is a multilamellar sheath generated by specialized glia called Schwann cells (SCs) in the peripheral nervous system (PNS), which serves to protect and insulate axons for rapid neuronal signaling.
Ackerman, Sarah D +9 more
core +6 more sources
Muscle-Related Plectinopathies
Cells, 2021 Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies.
Michaela M. Zrelski +2 more
doaj +1 more source
The rod domain is not essential for the function of plectin in maintaining tissue integrity [PDF]
, 2016 This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.-- et
Ketema, Mirjam +2 more
core +1 more source