Plectin: Dual Participation in Tumor Progression [PDF]
BiomoleculesThe plectin gene can encode a cytoskeletal linking protein, plectin, known for its interaction with three critical components of the cellular cytoskeleton: intermediate filaments, microtubules, and actin filaments.
Guan-Bin Song
exaly +6 more sources
The Role of Plectin Dysregulation in Cancer: Recent Advances [PDF]
MoleculesPlectin is a key cytolinker protein that functions as an integrator of the cytoskeletal networks by crosslinking intermediate filaments with actin filaments and microtubules.
Wenbin Wang +5 more
doaj +5 more sources
Plectin in Cancer: From Biomarker to Therapeutic Target [PDF]
Cells, 2021 The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to tumorigenesis, including cancer cell proliferation ...
Samantha M Perez, Siva Sai Krishna Dasa
exaly +5 more sources
Plectin in the Central Nervous System and a Putative Role in Brain Astrocytes
Cells, 2021 Plectin, a high-molecular-mass cytolinker, is abundantly expressed in the central nervous system (CNS). Currently, a limited amount of data about plectin in the CNS prevents us from seeing the complete picture of how plectin affects the functioning of ...
Maja Potokar, Jernej Jorgačevski
exaly +3 more sources
Unraveling the Oncogenic Characteristics of the Cytolinker, Plectin, in Esophageal Squamous Cell CarcinomaSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Tissue mechanics involved in carcinogenesis by regulating cell morphology and structure, cell-cell, and cell-extracellular matrix (ECM) interactions are not fully understood.
Lili Qiao +9 more
doaj +2 more sources
Phosphorylation of plectin by Akt3 promotes triple-negative breast cancer cell invasive migration [PDF]
iScienceSummary: Triple-negative breast cancer (TNBC) lacks targeted therapeutics and is aggressive with a poor prognosis. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, frequently deregulated in cancers, plays crucial roles in tumorigenesis and
Shixue Zheng +5 more
doaj +2 more sources
Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
Cells, 2021 This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies that provided comprehensive evidence for a concept where plectin acts as an IF recruiter, and ...
Gerhard Wiche
exaly +3 more sources
Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis [PDF]
eLifeThe most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor
Zuzana Outla +30 more
doaj +2 more sources
High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis [PDF]
BMC BiologyBackground Abundant research indicates that increased extracellular matrix (ECM) stiffness significantly enhances the malignant characteristics of hepatocellular carcinoma (HCC) cells.
Zhihui Wang +3 more
doaj +2 more sources
Impaired Autophagic Flux in Skeletal Muscle of Plectin‐Related Epidermolysis Bullosa Simplex With Muscular Dystrophy [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Plectin, a multifunctional cytolinker and intermediate filament stabilizing protein, is essential for muscle fibre integrity and function. Mutations in the human plectin gene (PLEC) cause autosomal recessive epidermolysis bullosa simplex with ...
Michaela M. Zrelski +12 more
doaj +2 more sources