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Plectin: Dual Participation in Tumor Progression
BiomoleculesThe plectin gene can encode a cytoskeletal linking protein, plectin, known for its interaction with three critical components of the cellular cytoskeleton: intermediate filaments, microtubules, and actin filaments.
Guanbin Song
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Plectin in Skin Fragility Disorders [PDF]
Cells, 2021 Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.
Dimitra Kiritsi +2 more
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Plectin-Isoform-Specific Rescue of Hemidesmosomal Defects in Plectin (–/–) Keratinocytes [PDF]
Journal of Investigative Dermatology, 2003 The various plectin isoforms are among the major crosslinking elements of the cytoskeleton. The importance of plectin in epithelia is convincingly supported by the severe skin blistering observed in plectin-deficient humans and mice. Here, we identified plectin 1a (> 500 kDa), a full length plectin variant containing the sequence encoded by the ...
Gerhard Wiche, Irmgard Fischer
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Cells, 2022 In light of recent progress in defining a unifying mechanism for the versatile functions and disease involvement of the cytolinker protein plectin, a series of invited review articles, together with an original research article, were published in Cells ...
Gerhard Wiche
doaj +4 more sources
Plectin in Cancer: From Biomarker to Therapeutic Target [PDF]
Cells, 2021 The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to tumorigenesis, including cancer cell proliferation ...
Samantha Perez, Lindsey Brinton
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Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
Cells, 2021 This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies that provided comprehensive evidence for a concept where plectin acts as an IF recruiter, and ...
Gerhard Wiche
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The Role of Plectin Dysregulation in Cancer: Recent Advances
MoleculesPlectin is a key cytolinker protein that functions as an integrator of the cytoskeletal networks by crosslinking intermediate filaments with actin filaments and microtubules.
Wenbin Wang +5 more
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Plectin in the Central Nervous System and a Putative Role in Brain Astrocytes
Cells, 2021 Plectin, a high-molecular-mass cytolinker, is abundantly expressed in the central nervous system (CNS). Currently, a limited amount of data about plectin in the CNS prevents us from seeing the complete picture of how plectin affects the functioning of ...
Maja Potokar, Jernej Jorgačevski
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Plectin-1 Targeted Dual-modality Nanoparticles for Pancreatic Cancer Imaging
EBioMedicine, 2018 Background: Biomarker-targeted molecular imaging holds promise for early detection of pancreatic cancer. The aim of this study was to design and evaluate a plectin-1 targeted multi-functional nanoparticle probe for pancreatic cancer imaging. Methods: 1,2-
Zhongqiu Wang, Donghui Li
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular OncologyPlecstatin (PST) is a potent anticancer agent in preclinical models, yet its precise mechanism of action and molecular specificity regarding its main targets, plectin and outer dense fiber protein 2 (ODF2), remain incompletely understood.
Zuzana Outla +10 more
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