Results 11 to 20 of about 4,450 (185)
Plectin in Skin Fragility Disorders [PDF]
Cells, 2021 Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.
Dimitra Kiritsi +2 more
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Cells, 2022 In light of recent progress in defining a unifying mechanism for the versatile functions and disease involvement of the cytolinker protein plectin, a series of invited review articles, together with an original research article, were published in Cells ...
Gerhard Wiche
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Plectin-1 Targeted Dual-modality Nanoparticles for Pancreatic Cancer Imaging
EBioMedicine, 2018 Background: Biomarker-targeted molecular imaging holds promise for early detection of pancreatic cancer. The aim of this study was to design and evaluate a plectin-1 targeted multi-functional nanoparticle probe for pancreatic cancer imaging. Methods: 1,2-
Yifen Zhang +2 more
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Interaction of Plectin with Keratins 5 and 14: Dependence on Several Plectin Domains and Keratin Quaternary Structure [PDF]
Journal of Investigative Dermatology, 2014 Plectin, a cytolinker of the plakin family, anchors the intermediate filament (IF) network formed by keratins 5 and 14 (K5/K14) to hemidesmosomes, junctional adhesion complexes in basal keratinocytes. Genetic alterations of these proteins cause epidermolysis bullosa simplex (EBS) characterized by disturbed cytoarchitecture and cell fragility.
Bouameur, Jamal-Eddine +5 more
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Identifying Plectin Isoform Functions through Animal Models
Cells, 2021 Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to intermediate filaments of all types and connects them to junctional complexes, organelles, and inner membrane systems.
Maria J. Castañón, Gerhard Wiche
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OMICS: A Journal of Integrative Biology, 2023 Plectin, encoded by PLEC , is a cytoskeletal and scaffold protein with a number of unique isoforms that act on various cellular functions such as cell adhesion, signal transduction, cancer cell invasion, and migration.
Hulya Gundesli +2 more
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Impaired Autophagic Flux in Skeletal Muscle of Plectin‐Related Epidermolysis Bullosa Simplex With Muscular Dystrophy [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Plectin, a multifunctional cytolinker and intermediate filament stabilizing protein, is essential for muscle fibre integrity and function. Mutations in the human plectin gene (PLEC) cause autosomal recessive epidermolysis bullosa simplex with ...
Michaela M. Zrelski +12 more
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Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding [PDF]
The Journal of Cell Biology, 1999 Hemidesmosomes are stable adhesion complexes in basal epithelial cells that provide a link between the intermediate filament network and the extracellular matrix. We have investigated the recruitment of plectin into hemidesmosomes by the α6β4 integrin and have shown that the cytoplasmic domain of the β4 subunit associates with an NH2-terminal fragment ...
Geerts, Dirk +8 more
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Rap2B drives tumorigenesis and progression of colorectal cancer through intestinal cytoskeleton remodeling [PDF]
Cell Death and DiseaseRas family protein plays a key role in transducing signals involved in cytoskeletal remodeling and cell adhesion, which are particularly important in the development of colorectal cancer (CRC).
Jiehui Di +9 more
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Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks [PDF]
Open BiologyEpithelia are multicellular sheets that form barriers defining the internal and external environments. The constant stresses acting at this interface require that epithelial sheets are mechanically robust and provide a selective barrier to the hostile ...
Zuzana Outla +4 more
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