Plectin in Skin Fragility Disorders [PDF]
Cells, 2021 Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.
Dimitra Kiritsi +2 more
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Cells, 2022 In light of recent progress in defining a unifying mechanism for the versatile functions and disease involvement of the cytolinker protein plectin, a series of invited review articles, together with an original research article, were published in Cells ...
Gerhard Wiche
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Plectin-1 Targeted Dual-modality Nanoparticles for Pancreatic Cancer Imaging
EBioMedicine, 2018 Background: Biomarker-targeted molecular imaging holds promise for early detection of pancreatic cancer. The aim of this study was to design and evaluate a plectin-1 targeted multi-functional nanoparticle probe for pancreatic cancer imaging. Methods: 1,2-
Zhongqiu Wang, Donghui Li
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Rap2B drives tumorigenesis and progression of colorectal cancer through intestinal cytoskeleton remodeling [PDF]
Cell Death and DiseaseRas family protein plays a key role in transducing signals involved in cytoskeletal remodeling and cell adhesion, which are particularly important in the development of colorectal cancer (CRC).
Jiehui Di +9 more
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Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks [PDF]
Open BiologyEpithelia are multicellular sheets that form barriers defining the internal and external environments. The constant stresses acting at this interface require that epithelial sheets are mechanically robust and provide a selective barrier to the hostile ...
Zuzana Outla +4 more
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Plectin (PLEC)-Related Intermediate Epidermolysis Bullosa Simplex without Extracutaneous Involvement with Response to Dapsone [PDF]
Indian Dermatology Online JournalPlectinopathies, the spectrum of diseases caused by plectin gene (PLEC) mutations, have a wide range of manifestations, mostly extracutaneous, like pyloric atresia, muscular dystrophy, and cardiomyopathy, along with cutaneous tense blistering ...
Anisha Biswal +4 more
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Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration [PDF]
Frontiers in ImmunologyPurposeRegulation of inflammation and re-epithelialization are critical for efficient wound healing. This study explores the role of human α1-antitrypsin (hAAT), an immunomodulatory protein, in modulating inflammation and promoting re-epithelialization ...
Idan Farber +21 more
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Desmoplakin CSM models unravel mechanisms regulating the binding to intermediate filaments and putative therapeutics for cardiocutaneous diseases [PDF]
Scientific ReportsArrhythmogenic cardiomyopathy (AC) is a common cause of sudden cardiac arrest and death in young adults. It can be induced by different types of mutations throughout the desmoplakin gene including the R2834H mutation in the extreme carboxyterminus tail ...
Cedric Badowski +3 more
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Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer [PDF]
Cell & BioscienceBackground Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall
Lanning Bai +6 more
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Plectin in the Central Nervous System and a Putative Role in Brain Astrocytes
Cells, 2021 Plectin, a high-molecular-mass cytolinker, is abundantly expressed in the central nervous system (CNS). Currently, a limited amount of data about plectin in the CNS prevents us from seeing the complete picture of how plectin affects the functioning of ...
Maja Potokar, Jernej Jorgačevski
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