Plectin in Skin Fragility Disorders [PDF]
Cells, 2021 Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.
Dimitra Kiritsi +2 more
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Cells, 2022 In light of recent progress in defining a unifying mechanism for the versatile functions and disease involvement of the cytolinker protein plectin, a series of invited review articles, together with an original research article, were published in Cells ...
Gerhard Wiche
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Rap2B drives tumorigenesis and progression of colorectal cancer through intestinal cytoskeleton remodeling [PDF]
Cell Death and DiseaseRas family protein plays a key role in transducing signals involved in cytoskeletal remodeling and cell adhesion, which are particularly important in the development of colorectal cancer (CRC).
Jiehui Di +9 more
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Plectin-1 Targeted Dual-modality Nanoparticles for Pancreatic Cancer Imaging
EBioMedicine, 2018 Background: Biomarker-targeted molecular imaging holds promise for early detection of pancreatic cancer. The aim of this study was to design and evaluate a plectin-1 targeted multi-functional nanoparticle probe for pancreatic cancer imaging. Methods: 1,2-
Donghui Li, Zhongqiu Wang
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Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks [PDF]
Open BiologyEpithelia are multicellular sheets that form barriers defining the internal and external environments. The constant stresses acting at this interface require that epithelial sheets are mechanically robust and provide a selective barrier to the hostile ...
Zuzana Outla +4 more
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Plectin (PLEC)-Related Intermediate Epidermolysis Bullosa Simplex without Extracutaneous Involvement with Response to Dapsone [PDF]
Indian Dermatology Online JournalPlectinopathies, the spectrum of diseases caused by plectin gene (PLEC) mutations, have a wide range of manifestations, mostly extracutaneous, like pyloric atresia, muscular dystrophy, and cardiomyopathy, along with cutaneous tense blistering ...
Anisha Biswal +4 more
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Polyarginine Peptide R11–Actin Interaction Induces a Domino Effect on Cytoskeleton Remodeling to Suppress Bladder Cancer Metastasis [PDF]
ResearchCytoskeletal remodeling, particularly actin dynamics, is a central driver of tumor metastasis. However, actin-targeting agents have faced major translational barriers due to poor specificity and the absence of defined druggable sites.
Zhenghong Liu +22 more
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Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma [PDF]
Journal of Biomedical ScienceBackground The expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression of the major IF-based cytolinker, plectin (PLEC), and its contribution to GBM migration and ...
Maja Žugec +18 more
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Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration [PDF]
Frontiers in ImmunologyPurposeRegulation of inflammation and re-epithelialization are critical for efficient wound healing. This study explores the role of human α1-antitrypsin (hAAT), an immunomodulatory protein, in modulating inflammation and promoting re-epithelialization ...
Idan Farber +21 more
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Desmoplakin CSM models unravel mechanisms regulating the binding to intermediate filaments and putative therapeutics for cardiocutaneous diseases [PDF]
Scientific ReportsArrhythmogenic cardiomyopathy (AC) is a common cause of sudden cardiac arrest and death in young adults. It can be induced by different types of mutations throughout the desmoplakin gene including the R2834H mutation in the extreme carboxyterminus tail ...
Cedric Badowski +3 more
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