Results 31 to 40 of about 7,348 (200)
[99mTc]Tc-Labeled Plectin-Targeting Peptide as a Novel SPECT Probe for Tumor Imaging
Pharmaceutics, 2022 Certain receptors are often overexpressed during tumor occurrence and development and closely correlate with carcinogenesis. Owing to its overexpression on the cell membrane and cytoplasm of various tumors, plectin, which is involved in tumor ...
Jiali Gong +4 more
doaj +1 more source
Interaction of Plectin with Keratins 5 and 14: Dependence on Several Plectin Domains and Keratin Quaternary Structure [PDF]
Journal of Investigative Dermatology, 2014 Plectin, a cytolinker of the plakin family, anchors the intermediate filament (IF) network formed by keratins 5 and 14 (K5/K14) to hemidesmosomes, junctional adhesion complexes in basal keratinocytes. Genetic alterations of these proteins cause epidermolysis bullosa simplex (EBS) characterized by disturbed cytoarchitecture and cell fragility.
Bouameur, Jamal-Eddine +5 more
openaire +4 more sources
Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma [PDF]
, 2014 Background: Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There
Oddveig G. Rikardsen +41 more
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Life-long course and molecular characterization of the original Dutch family with epidermolysis bullosa simplex with muscular dystrophy due to a homozygous novel plectin point mutation [PDF]
, 2004 Plectin is one of the largest and most versatile cytolinker proteins known. Cloned and sequenced in 1991, it was later shown to have nonsense mutations in recessive epidermolysis bullosa with muscular dystrophy.
De Groot, WP +7 more
core +1 more source
PLoS Genetics, 2011 Autosomal recessive mutations in the cytolinker protein plectin account for the multisystem disorders epidermolysis bullosa simplex (EBS) associated with muscular dystrophy (EBS-MD), pyloric atresia (EBS-PA), and congenital myasthenia (EBS-CMS).
Gernot Walko +12 more
doaj +1 more source
Effects of Plectin Depletion on Keratin Network Dynamics and Organization. [PDF]
PLoS ONE, 2016 The keratin intermediate filament cytoskeleton protects epithelial cells against various types of stress and is involved in fundamental cellular processes such as signaling, differentiation and organelle trafficking. These functions rely on the cell type-
Marcin Moch +13 more
doaj +1 more source
Stable isotopic labeling in proteomics [PDF]
, 2008 Labeling of proteins and peptides with stable heavy isotopes (deuterium, carbon-13, nitrogen-15, and oxygen-18) is widely used in quantitative proteomics.
Beynon +69 more
core +2 more sources
Identification of proteins in the postsynaptic density fraction by mass spectrometry [PDF]
, 2000 Our understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Jensen, Ole N. +5 more
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Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease. [PDF]
Adv Sci (Weinh)Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Prakash A, Iskratsch T.
europepmc +2 more sources
Biomedicines, 2022 The endothelium plays an important role in the transcytosis of lipoproteins. According to one of the theories, endothelial injury is a triggering factor for the development of atherosclerosis, and intracellular structures, including components of the ...
Anton S. Shakhov, Irina B. Alieva
doaj +1 more source