Results 31 to 40 of about 4,450 (185)

Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer [PDF]

Cell & Bioscience
Background Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall
Lanning Bai, Xueqian Qian, Hui Zhang, Yi Yuan, Xiaodong Cui, Min Cheng, Yangyang Han   +6 more
doaj   +2 more sources

Functional and Genetic Analysis of Plectin in Skin and Muscle

, 2016
Plectin is a large cytoskeletal linker protein with a multitude of functions affecting various cellular processes. It is expressed as several different isoforms from a highly complex gene. Both, this transcript diversity (mainly caused by short 5'-sequences contained in alternative first exons) and the size (>500 kDa) of the resulting proteins, present
Rezniczek, Günther A., Winter, Lilli, Walko, Gernot, Wiche, Gerhard   +3 more
openaire   +5 more sources

Plectin promotes tumor formation by B16 mouse melanoma cells via regulation of Rous sarcoma oncogene activity

BMC Cancer, 2022
Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation ...
Kana Mizuta, Takuma Matsubara, Akino Goto, William N. Addison, Mitsushiro Nakatomi, Kou Matsuo, Yukiyo Tada-Shigeyama, Tatsuki Yaginuma, Hiromi Honda, Izumi Yoshioka, Shoichiro Kokabu   +10 more
doaj   +1 more source

Z-Disk-Associated Plectin (Isoform 1d): Spatial Arrangement, Interaction Partners, and Role in Filamin C Homeostasis

Cells, 2023
Plectin, a highly versatile cytolinker protein, is crucial for myofiber integrity and function. Accordingly, mutations in the human gene (PLEC) cause several rare diseases, denoted as plectinopathies, with most of them associated with progressive muscle ...
Lilli Winter, Ilona Staszewska-Daca, Stefan Zittrich, Fatiha Elhamine, Michaela M. Zrelski, Katy Schmidt, Irmgard Fischer, Christian Jüngst, Astrid Schauss, Wolfgang H. Goldmann, Robert Stehle, Gerhard Wiche   +11 more
doaj   +1 more source

Vimentin Intermediate Filaments: A Paradigm Shift From Static Structure to Dynamic Cytoplasmic Network [PDF]

Bioessays
Vimentin intermediate filaments form a dynamic, motile network that interacts with microfilaments and microtubules. We propose a hybrid transport model to explain vimentin filament dynamics through cytoskeletal crosstalk and organelle‐associated transport.
Renganathan B, Adam S, Gelfand V.
europepmc   +2 more sources

Muscle-Related Plectinopathies

Cells, 2021
Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies.
Michaela M. Zrelski, Monika Kustermann, Lilli Winter   +2 more
doaj   +1 more source

[^99mTc]Tc-Labeled Plectin-Targeting Peptide as a Novel SPECT Probe for Tumor Imaging

Pharmaceutics, 2022
Certain receptors are often overexpressed during tumor occurrence and development and closely correlate with carcinogenesis. Owing to its overexpression on the cell membrane and cytoplasm of various tumors, plectin, which is involved in tumor ...
Jiali Gong, Lingzhou Zhao, Jiqin Yang, Meilin Zhu, Jinhua Zhao   +4 more
doaj   +1 more source

Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna.

PLoS Genetics, 2011
Autosomal recessive mutations in the cytolinker protein plectin account for the multisystem disorders epidermolysis bullosa simplex (EBS) associated with muscular dystrophy (EBS-MD), pyloric atresia (EBS-PA), and congenital myasthenia (EBS-CMS).
Gernot Walko, Nevena Vukasinovic, Karin Gross, Irmgard Fischer, Sabrina Sibitz, Peter Fuchs, Siegfried Reipert, Ute Jungwirth, Walter Berger, Ulrich Salzer, Oliviero Carugo, Maria J Castañón, Gerhard Wiche   +12 more
doaj   +1 more source

Effects of Plectin Depletion on Keratin Network Dynamics and Organization. [PDF]

PLoS ONE, 2016
The keratin intermediate filament cytoskeleton protects epithelial cells against various types of stress and is involved in fundamental cellular processes such as signaling, differentiation and organelle trafficking. These functions rely on the cell type-
Marcin Moch, Reinhard Windoffer, Nicole Schwarz, Raphaela Pohl, Andreas Omenzetter, Uwe Schnakenberg, Fabian Herb, Kraisorn Chaisaowong, Dorit Merhof, Lena Ramms, Gloria Fabris, Bernd Hoffmann, Rudolf Merkel, Rudolf E Leube   +13 more
doaj   +1 more source

Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin [PDF]

, 1996
The cornified envelope is a layer of transglutaminase cross-linked protein that is deposited under the plasma membrane of keratinocytes in the outermost layers of the epidermis.
Dooley, TP, Hajibagheri, MAN, Watt, FM, M A Hajibagheri, Ruhrberg, C, Simon, M, F M Watt, C Ruhrberg, M Simon, T P Dooley   +9 more
core   +1 more source