Results 51 to 60 of about 4,450 (185)

Plectin isoforms as organizers of intermediate filament cytoarchitecture [PDF]

BioArchitecture, 2011
Intermediate filaments (IFs) form cytoplamic and nuclear networks that provide cells with mechanical strength. Perturbation of this structural support causes cell and tissue fragility and accounts for a number of human genetic diseases. In recent years, important additional roles, nonmechanical in nature, were ascribed to IFs, including regulation of ...
Wiche, Gerhard, Winter, Lilli
openaire   +3 more sources

Plectin interacts with the rod domain of type III intermediate filament proteins desmin and vimentin

, 2011
Plectin is a versatile cytolinker protein critically involved in the organization of the cytoskeletal filamentous system. The muscle-specific intermediate filament (IF) protein desmin, which progressively replaces vimentin during differentiation of ...
Nadja Begré, Yves Gontier, Luca Borradori, Fontao, Lionel, Bouameur, Jamal-Eddine, Steiner-Champliaud, Marie-France, Bertrand Favre, Frias, Miguel A, Miguel A. Frias, Borradori, Luca, Yann Schneider, Favre, Bertrand, Lingasamy, Prakash, Prakash Lingasamy, Begré, Nadja, Gontier, Yves, Jamal-Eddine Bouameur, Marie-France Steiner-Champliaud, Lionel Fontao, Schneider, Yann   +19 more
core   +1 more source

Hemidesmosomal Proteins in Oral Cancer Progression: An Immunohistochemical Study of Human and Mouse

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease pathogenesis remains limited.
Nikhil Mongia, Ali Ibrahim Mohammed, Michael McCullough, Rita Paolini, James A. Rickard, Massimo Mascolo, Silvia Varricchio, Lorraine A. O'Reilly, John Silke, Nicola Cirillo, Antonio Celentano   +10 more
wiley   +1 more source

Immunofluorescence microscopy shows efficient down regulation of plectin in stably transfected A431 clones producing plectin shRNA.

, 2016
The fluorescence images (maximum intensity projections of complete cells) were recorded in AK13-1 subclones stably expressing HK13-EGFP and either scramble control shRNAs or plectin shRNAs.
Fabian Herb (2579410), Kraisorn Chaisaowong (2579407), Rudolf E. Leube (132404), Marcin Moch (2579392), Andreas Omenzetter (2579401), Reinhard Windoffer (132400), Lena Ramms (2579404), Uwe Schnakenberg (2579395), Raphaela Pohl (2579398), Nicole Schwarz (313667), Bernd Hoffmann (191620), Rudolf Merkel (191622), Gloria Fabris (837999), Dorit Merhof (290212)   +13 more
core   +1 more source

Purification and Structural Analysis of Plectin and BPAG1e

, 2016
Plectin and BPAG1e belong to the plakin family of high-molecular-weight proteins that interconnect the cytoskeletal systems and anchor them to junctional complexes. Plectin and BPAG1e are prototypical plakins with a similar tripartite modular structure.
Manso, José A., García-Rubio, Inés, Gómez-Hernández, María, Ortega, Esther, Martínez Buey, Rubén, Carballido Vázquez, Ana M., Carabias, Arturo, Alonso-García, Noelia, Pereda, José M. de   +8 more
openaire   +3 more sources

ECMO Support in Paraneoplastic Pemphigus With Respiratory Failure: A Case Report With Immune Cell Monitoring

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Paraneoplastic pemphigus (PNP) is a life‐threatening autoimmune blistering disease with a mortality rate of 70%–90%, driven largely by respiratory complications such as bronchiolitis obliterans. Managing respiratory failure in these patients remains exceptionally difficult.
Lu Li, Danxia Chen, Linzi Jin, Qinqin Shu, Juan He, Yan Li   +5 more
wiley   +1 more source

Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma

Journal of Biomedical Science
Background The expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression of the major IF-based cytolinker, plectin (PLEC), and its contribution to GBM migration and ...
Maja Žugec, Borut Furlani, Maria J. Castañon, Boštjan Rituper, Irmgard Fischer, Giuseppe Broggi, Rosario Caltabiano, Giuseppe M. V. Barbagallo, Michelino Di Rosa, Daniele Tibullo, Rosalba Parenti, Nunzio Vicario, Saša Simčič, Victorio Martin Pozo Devoto, Gorazd B. Stokin, Gerhard Wiche, Jernej Jorgačevski, Robert Zorec, Maja Potokar   +18 more
doaj   +1 more source

Consequences of plectin ablation on the various intermediate filament systems in skeletal muscle

European Journal of Cell Biology
Plectin, a highly versatile and multifunctional cytolinker, acts as a central connector of the intermediate filament (IF) and other cytoskeletal systems.
Marta Rocha, Jonas Petsch, Dorothea Schultheis, Michaela M. Zrelski, Petra Fichtinger, Inga Koneczny, Samuel Meier-Menches, Gerhard Wiche, Rolf Schröder, Lilli Winter   +9 more
doaj   +1 more source

Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. [PDF]

PLoS ONE, 2013
Prostate cancer is a clinically heterogeneous disease, ranging from indolent asymptomatic disease to very aggressive metastatic and life threatening forms of the disease. Distant metastasis represents the major lethal cause of prostate cancer.
Tanya C Burch, Megan T Watson, Julius O Nyalwidhe   +2 more
doaj   +1 more source

Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice

EBioMedicine, 2022
Summary: Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high
Wenjia Zhang, Xiaolong Liang, Liang Zhu, Xinyu Zhang, Zhengyu Jin, Yang Du, Jie Tian, Huadan Xue   +7 more
doaj   +1 more source