Results 81 to 90 of about 4,450 (185)

Population Genomics Provides Novel Insights Into Evolutionary Relationships and Local Adaptation of Two Ecotypes Coilia nasus

Ecology and Evolution, Volume 15, Issue 12, December 2025.
Based on whole‐genome resequencing, we determined that the freshwater‐resident form (C. nasus taihuensis) is an ecotype of anadromous Coilia nasus, not a distinct subspecies. The two ecotypes diverged approximately 4.6 thousand years ago, coinciding with the formation of Tai Lake.
Fengjiao Ma, Sheng Wang, Wenzhi Ma, Hui Wang, Haotian Jin, Legen Peng, Guojun Yin, Kai Liu   +7 more
wiley   +1 more source

Plectin is a regulator of prostate cancer growth and metastasis

Oncogene, 2020
Prostate cancer is responsible for over 30,000 US deaths annually, attributed largely to incurable metastatic disease. Here, we demonstrate that high levels of plectin are associated with localized and metastatic human prostate cancer when compared to benign prostate tissues.
Mark Buckup, Meghan A. Rice, En-Chi Hsu, Fernando Garcia-Marques, Shiqin Liu, Merve Aslan, Abel Bermudez, Jiaoti Huang, Sharon J. Pitteri, Tanya Stoyanova   +9 more
openaire   +3 more sources

The structure of the plakin domain of plectin reveals an extended rod-like shape

, 2018
Plakins are large multi-domain proteins that interconnect cytoskeletal structures. Plectin is a prototypical plakin that tethers intermediate filaments to membrane-associated complexes.
Ortega, Esther, Carabias, Arturo, Martínez Buey, Rubén, Carballido Vázquez, Ana M., Manso, José A., Pereda, José M. de, Sonnenberg, Arnoud   +6 more
core   +1 more source

Issue Information

Molecular Oncology, Volume 20, Issue 6, Page 1383-1384, June 2026.
Cover To reduce the global disease burden more effectively, cancer interception should be established as a fundamental pillar of oncology, integrated with prevention, early detection and therapeutic management. Read the full EACR Viewpoint article by Charlotte Grieco, Tej Pandya and Charles Swanton on conceptual frameworks for cancer prevention through
wiley   +1 more source

R405W Desmin Knock‐In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Mutations in the desmin gene cause skeletal myopathies and cardiomyopathies. The objective of this study was to elucidate the molecular pathology induced by the expression of R405W mutant desmin in murine skeletal muscle. Methods A comprehensive characterization of the skeletal muscle pathology in hetero‐ and homozygous R405W desmin
Sabrina Batonnet‐Pichon, Florence Delort, Alain Lilienbaum, Carolin Berwanger, Dorothea Schultheis, Ursula Schlötzer‐Schrehardt, Andreas Schmidt, Steffen Uebe, Yosra Baiche, Tom J. Eisenack, Débora Broch Trentini, Markus Mallek, Leonid Mill, Ana Ferreiro, Bettina Eberhard, Thomas Lücke, Markus Krüger, Christian Thiel, Rolf Schröder, Christoph S. Clemen   +19 more
wiley   +1 more source

Plectin Isoform 1c

, 2010
Plectin, ein > 500 kD großer Cytolinker ist, wie in verschiedenen Zellsystemen nachgewiesen werden konnte, in der Lage mit Tubulin zu interagieren. In dieser Arbeit konnte in Cosedimentations-Experimenten gezeigt werden, dass die Plectin-Isoform 1c ...
Ertl, Alexander
core  

Plectin Missense Mutation p.Leu319Pro in the Pathogenesis of Autosomal Recessive Epidermolysis Bullosa Simplex

Acta Dermato-Venereologica, 2020
is missing (Short communication)
Wei-Ting Tu, Peng-Chieh Chen, Ping-Chen Hou, Hsin-Yu Huang, Jing-Yu Wang, Sheau-Chiou Chao, Julia Yu-Yun Lee, John A. McGrath, Ken Natsuga, Chao-Kai Hsu   +9 more
doaj   +1 more source

Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 12, Page 1555-1564, December 2025.
Summary Background and Objectives Pemphigoid diseases are primarily mediated by IgG or IgA autoantibodies against the cutaneous basement membrane zone (BMZ). Although recent observations suggest the existence of exclusively IgM‐mediated pemphigoid disease, a larger study is lacking.
Kaan Yilmaz, Stephanie Goletz, Christoph M. Hammers, Katharina Boch, Claudia Zeidler, Henning Wiegmann, Estelle Bergmann, Tina Rastegar Lari, Onur Dikmen, Nina Häring, Robert Strohal, Andreas Kleinheinz, Eva N. Hadaschik, Nina van Beek, Sonja Ständer, Enno Schmidt   +15 more
wiley   +1 more source

Epidermolysis bullosa simplex: genotype-phenotype correlations

Vestnik Dermatologii i Venerologii
Epidermolysis bullosa simplex (EBS) includes a group of diseases characterized by varying severity, possible damage to visceral organs, and various outcomes ranging from complete regression of the rash to death. The initial clinical manifestations of EBS
Vadim V. Chikin, Arfenia E. Karamova
doaj   +1 more source

PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736.

PLoS ONE, 2015
The integrin α6β4, a major component of hemidesmosomes (HDs), stabilizes keratinocyte cell adhesion to the epidermal basement membrane through binding to the cytoskeletal linker protein plectin and association with keratin filaments.
Lisa Te Molder, Arnoud Sonnenberg
doaj   +1 more source