Results 171 to 180 of about 50,540 (257)

The Omnicausal Model Reveals the Highly Polyfactorial Nature of Complex Diseases. [PDF]

Genet Epidemiol
Márquez-Luna C, Tournaire M, Rocheleau G, Do R, Verbanck M.   +4 more
europepmc   +1 more source

The roads most traveled: genetic convergence in plant repeated evolution

New Phytologist, EarlyView.
Observation of a genotype–phenotype association in a focal lineage (magnifying lens) provides a starting point for predicting homolog reuse during repeated trait evolution. This review suggests that the likelihood that mutations in homologous genes contribute to similar phenotypes in other lineages depends on both mutational effect stability (MES) and ...
James W. Satterlee
wiley   +1 more source

Nondefense functions of plant specialized metabolites: ecological phenomena, molecular mechanisms, and evolutionary implications

New Phytologist, EarlyView.
Nonexhaustive overview of empirically validated nondefense functions caused by or correlated with variation in four well‐studied classes of plant specialized metabolites (PSMs) – glucosinolates (green text), alkaloids (blue text), terpenoids (yellow text), and flavonoids/polyphenols (purple text) – separated into different categories of nondefense ...
Lauren N. Carley
wiley   +1 more source

Psychiatric disorders and gynecologic tumors: A 2-sample Mendelian randomization study of 20 exposure-outcome pairs. [PDF]

Medicine (Baltimore)
Zheng P, Chen W, Jiang M.
europepmc   +1 more source

The Causal Role of Adiposity in Mental Illness: A Systematic Review and Meta‐Analysis of Mendelian Randomization Studies

Obesity Reviews, EarlyView.
ABSTRACT Objective This study aimed to examine the causal effect of adiposity on mental illnesses by summarizing and assessing evidence from Mendelian randomization (MR) studies. Method Searches were conducted on Embase, Medline, and Web of Science from database inception to September 22nd, 2025.
Min Gao, Paul J. Doody, Dimitrios A. Koutoukidis, Yebo Yu, Paul Aveyard, Richard Stevens, Padraig C. Dixon   +6 more
wiley   +1 more source

Sex hormone-binding globulin increases lumbar fracture risk via bone density, inflammation, and insulin pathways: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Xia G, Yang R, Zhou Y, Luo S, Shao J, Kong Q, Luo H, Li X.   +7 more
europepmc   +1 more source

Causal Effects of Type 2 Diabetes Mellitus on Chronic Periodontitis and the Mediating Role of Oxidative Stress: Evidence From Mendelian Randomization and Mediation Analysis

Oral Diseases, EarlyView.
ABSTRACT Background Type 2 diabetes mellitus (T2DM) is associated with an increased risk of chronic periodontitis, but genetic evidence and oxidative stress‐related pathways remain unclear. Objective This study assessed the genetically inferred association between T2DM and chronic periodontitis, evaluated oxidative stress biomarkers as potential ...
Mengjie Kong, James Kit Hon Tsoi, Kang Li, Cynthia Kar Yung Yiu   +3 more
wiley   +1 more source

Gene-level complexity explains genome-wide variation in the distribution of fitness effects. [PDF]

Mol Biol Evol
Yıldırım B, James JE.
europepmc   +1 more source

Natural and CRISPR/Cas9 Editing Variations of Dual‐uORFs Synergistically Increase the Nutritional Value of Silage Maize Feed

Plant Biotechnology Journal, EarlyView.
ABSTRACT The precise enhancement of nutritional quality in silage maize is a core strategy for increasing livestock production efficiency. Through evolutionary analysis of multiple plant species, we identified two functionally synergistic upstream open reading frames (uORF1 and uORF2) within the 5′ untranslated region of the gene encoding GDP‐L ...
Jing Zhou, Xi Wang, Yajing Zhang, Xinhao Luo, Shuyao Quan, Jie Ji, Lixue Sun, Xinyang Chen, Jin Chen, Jianbo Cheng, Jun Fan, Changsheng Li, Beijiu Cheng, Xiaoyu Li   +13 more
wiley   +1 more source

Different genetic associations of chronic lung diseases and lung cancer risk in European and East Asian populations. [PDF]

Chin Med J (Engl)
Zhang Y, Wu X, Li S, Wu X, Song X, Duan J.   +5 more
europepmc   +1 more source