Results 181 to 190 of about 37,616 (263)

Association of depression with keratitis: A bidirectional 2-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhang Y, Niu D, Chen M, Ji M, Zhang J, Zhou R.   +5 more
europepmc   +1 more source

Atorvastatin Reduces Alcohol‐Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol‐Disulfide Imbalance in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Atorvastatin (40 mg/kg) inhibited fibrosis, hypertrophy, apoptosis, inflammation, and oxidative stress caused by alcohol consumption. It may contribute to the regulation of mitochondrial function and thiol/disulfide balance by limiting alcohol‐related heart and liver damage.
Cumaali Demirtas, Şahhan Kılıç, Mert Babaoğlu, Süha Asal, Elif Gökçe Tenekeci, Hakan Beyaztaş, Eray Metin Guler, Salime Pelin Erguven, Kubra Sevgin   +8 more
wiley   +1 more source

Risk factors of ovarian cancer: a systematic review and meta-analysis of Mendelian randomiation studies. [PDF]

J Public Health (Oxf)
Yalew M, Lumsden AL, Mulugeta A, Madakkatel I, Lee SH, Oehler MK, Mäenpää J, Hyppönen E.   +7 more
europepmc   +1 more source

Patterns of Biochemical and Developmental Pleiotropy

Cold Spring Harbor Symposia on Quantitative Biology, 1956
openaire   +2 more sources

Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration

MedComm, Volume 7, Issue 8, August 2026.
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji, Sha Liu, Ying Zhang, Junya Zhu, Chang Huang, Ya Zhao, Jiao Xia, Wan Mu, Jin Yao, Biao Yan   +9 more
wiley   +1 more source

Causal Effects of Gut Microbiota and Associated Metabolites on Retinal Diseases and Visual Impairment: A Mendelian Randomization Study. [PDF]

J Ophthalmol
Yu C, Dong L, Zhang R, Li H, Shi X, Wu H, Zhou W, Li Y, Wei WB.   +8 more
europepmc   +1 more source

From prediction to intervention: Paradigm shifts in causal AI for precision medicine and large‐scale cohorts

VIEW, Volume 7, Issue 4, August 2026.
Large‐scale cohorts and multimodal biomedical data have enabled powerful predictive models for clinical risk stratification, but prediction alone cannot guide effective interventions. This review introduces causal artificial intelligence as a design‐first framework that integrates target trial emulation, causal discovery, and robust effect estimation ...
Linlin Cao, Yudian Xu, Yifan Chen, Honghao Huang, Wei Xu, Jun Pu   +5 more
wiley   +1 more source

Chronic Obstructive Pulmonary Disease Influence on Lung Cancer Risk Through Blood Metabolite Mediation: A Two-Sample Mendelian Randomisation and Mediation Analysis. [PDF]

Int J Chron Obstruct Pulmon Dis
Cao YN, Wang L, Fan HS, Zhang ZJ.
europepmc   +1 more source

Apiotrichum‐Centered Fungal Interaction Network Disturbance Correlates With Increased Arterial Stiffness

Aging Cell, Volume 25, Issue 8, August 2026.
Apiotrichum‐centered gut fungal network disturbance correlates with increased arterial stiffness. Five driver genera including Apiotrichum, Mycothermus, Flavocillium, Hyaloscypha, and Microscypha regulate the interaction shift. Thirty‐nine metabolites comprising organic acids, fatty acyls, and sucrose target vasoconstriction regulators CYP11B2, ROCK2 ...
Jiarui Chen, Jialin He, Bingqi Ye, Jialu Yang, Ludi Liu, Jingmeng Ju, Sinan Li, Benjie Li, Min Xia, Yan Liu   +9 more
wiley   +1 more source

Mendelian Randomization to Examine the Causal Effects of Cystatin on Ovarian Lesions. [PDF]

Int J Womens Health
Yan T, Guo L, Lu R.
europepmc   +1 more source