Results 201 to 210 of about 37,616 (263)

An exploratory Mendelian randomization study on the genetically predicted effects of circulating blood cells on osteoarthritis risk. [PDF]

Clinics (Sao Paulo)
Zhou L, Jia J, Chen X, Chen T.
europepmc   +1 more source

Multi‐Omics Profiling Identifies Novel Therapeutic Targets and Pathobiological Mechanisms in Oral Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Oral cancer (OC) remains a therapeutic challenge due to limited validated targets. Cis‐pQTLs from the deCODE cohort (n = 35,559) were harmonized with OC‐GWAS (3547 cases and 691,466 controls) meta‐data through a two‐sample Mendelian randomization (MR) framework.
Meishan Huang, Hongwei Wang, Xiaoqiang Mo, Xiong Huang, Tao Liang, Xiuwen Mo, Minsi Li, Rong Fu, Xidai Long, Xuanping Huang   +9 more
wiley   +1 more source

Causal Effects of Diet on Atopic Dermatitis: A Mendelian Randomization Study Implicating Lipid Pathways and Clinical Implications. [PDF]

Clin Cosmet Investig Dermatol
Wen X, Xiao Q, Wang S, Wu J, Li S, Yu T, Zhou M.   +6 more
europepmc   +1 more source

Ectopic Expression of ScALDH21 From a Desert Moss Enhances Cotton Resistance to Verticillium Wilt via the Modulation of Jasmonates and Phenylpropanoid Pathways

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4916-4932, August 2026.
ABSTRACT Biotic stresses, particularly Verticillium wilt (VW), lead to a global decline in cotton yields. Here, we demonstrate that ectopic expression of ScALDH21, a gene from the desiccation‐tolerant moss Syntrichia caninervis Mitt. and absent in angiosperms, enhances cotton's resistance to VW.
Honglan Yang, Xiaoshuang Li, Tohir A. Bozorov, Jianwei Zhang, Aerguli Jiamahate, Dawei Zhang, Jiancheng Wang, Qilin Yang, Zongrang Liu, Dina Mahesati, Haijiang Xu, Shuangxia Jin, Daoyuan Zhang, Yongqiang Dai   +13 more
wiley   +1 more source

Genetic Evidence Links Gestational Diabetes Mellitus to Increased ER-Negative Breast Cancer Risk Through a Mendelian Randomization Analysis. [PDF]

Int J Endocrinol
Peng W, Huang Z, Zhang M.
europepmc   +1 more source

Designed Alleles of ZmRap2.7 Decouple the Trade‐Off Between Early Flowering and Yield Penalty

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4966-4983, August 2026.
ABSTRACT Flowering time genes often exhibit pleiotropic effects. In particular, early flowering is frequently associated with reduced grain yield due to a shorter growth period. This trade‐off poses a major challenge for developing early‐maturing and high‐yielding varieties, a key breeding objective in modern maize production. Here, we demonstrate that
Shumin Wang, Junjie He, Lufei Zhang, Li Guo, Ruchang Ren, Xu Han, Lishuan Wu, Huayuan Zhang, Dezhi Deng, Xiangyang Guo, Fang Yang, Chenglong Wang, Feng Tian, Yameng Liang   +13 more
wiley   +1 more source

Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load. [PDF]

Science
Pai SV, Humphrey PT, Simonet C, Kosheleva K, Limdi A, Desai MM.   +5 more
europepmc   +1 more source

Locally adapted Arabidopsis thaliana accessions show transcriptomic plasticity in a multi‐timescale analysis of whole‐genome gene expression in a natural environment

Plant Biology, Volume 28, Issue 5, Page 1641-1656, August 2026.
Natural Arabidopsis thaliana accessions showed remarkable plasticity in both life‐cycle phenology and whole‐genome gene expression patterns in in natura field experiments. Nevertheless, local adaptation in fitness‐related life‐history traits can also be detected at the whole‐genome gene expression level.
A. Martínez‐Pérez, R. de la Mata, F. J. Romero‐Campero, R. Gómez, M. Calonje, J. M. Romero, M. T. Ruiz, F. Valverde, F. X. Picó   +8 more
wiley   +1 more source

Mendelian randomization analyses explore the relationship between inflammatory bowel disease and genitourinary diseases. [PDF]

Medicine (Baltimore)
Cao H, Shi C, Dai X, Yuan B, Yang G, Wang S.   +5 more
europepmc   +1 more source

35 blood and urine biomarkers and digestive system cancers: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Yang C, Xing B, Zhang Z, Jia Y, Peng L.
europepmc   +1 more source