Results 221 to 230 of about 50,540 (257)

Genetically predicted body mass index and self-reported hearing difficulty: a two-sample Mendelian randomization study with external replication. [PDF]

J Otol
Xue Y, Ma H, Yang L, Liu Q.
europepmc   +1 more source

Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10428-10438, November 2026.
ABSTRACT Background Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs.
Shuang Liao, Gabriel Chun Yin Sung, Yiwen Liang, Chenxi Li, Shiu Lun Au Yeung   +4 more
wiley   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, Volume 179, Issue 3, Page 337-349, November 2026.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

Causal relationship between dietary habits and low hand grip strength: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liu E, Sun F, Peng D, Xu W, Zou Q, Chen X, Wu X.   +6 more
europepmc   +1 more source

Population Differentiation and Polygenic Selection in the Finnish Ayrshire Cows Selected on Genomic Information

Journal of Animal Breeding and Genetics, Volume 143, Issue 6, Page 774-783, November 2026.
ABSTRACT The Finnish Ayrshire cattle belong to the Nordic Red breeds. The basis of selection in Nordic Red breeds shifted from traditional pedigree‐based breeding values to genomic breeding values between 2011 and 2014. Joint genetic evaluation and admixture among the Nordic Red breeds have led to the formation of a composite Nordic Red population ...
Katri Sarviaho, Minna Koivula, Terhi Iso‐Touru, Pekka Uimari, Katja Hänninen   +4 more
wiley   +1 more source

Divergent associations between adiposity and hernia subtypes in European populations: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Lu Y, Yuan H, Zhang K, Liu D.
europepmc   +1 more source

Genetic Evaluation for Functional Longevity in Nellore Cattle

Journal of Animal Breeding and Genetics, Volume 143, Issue 6, Page 834-845, November 2026.
ABSTRACT Stayability (STAY) presents limitations in capturing genetic variability among animals with varying calving records up to 76 months of age. Furthermore, because STAY is measured late in life (typically at 6 years of age), it inherently prolongs generation intervals.
Gabriele de Souza Silva Fernandes, Dalila Ribeiro dos Santos, Arione Augusti Boligon, Mário Luiz Santana, Gilberto Romeiro de Oliveira Menezes, Denise Rocha Ayres, Annaiza Braga Bignardi, Rodrigo Junqueira Pereira   +7 more
wiley   +1 more source

Causal association between air pollution and functional outcome after ischemic stroke: Evidence from 2-sample MR study. [PDF]

Medicine (Baltimore)
Zhang Y, Liu X, Ge Y, Liu Y, Xu R, Xu X.
europepmc   +1 more source

Multi-omics causal inference of childhood asthma triggered by ambient particulate matter. [PDF]

ERJ Open Res
Li H, Ren X, Lei X, Li Y, Dong W.
europepmc   +1 more source