Results 221 to 230 of about 37,616 (263)
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Biochemical analysis of pleiotropy in Dictyostelium
Developmental Biology, 1978Abstract The patterns of accumulation of five developmentally regulated enzymes were determined in four aggregateless mutant strains of Dictyostelium . Previous analyses of these strains had predicted that they should not accumulate these markers.
W F, Loomis, J, Morrissey, M, Lee
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Pleiotropy of microRNA-192 in the kidney
Biochemical Society Transactions, 2012Diverse aetiologies result in significant deviation from homoeostasis in the kidney, leading to CKD (chronic kidney disease). CKD progresses to end-stage renal disease principally as a result of renal fibrosis, although the molecular mechanisms underlying this fibrotic process are still poorly understood.
Robert H, Jenkins +4 more
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Statin Pleiotropy: Fact or Fiction?
American Journal of Critical Care, 2004Accumulating evidence from clinical trials and basic research indicates that statin therapy favorably influences a number of diverse clinical events through both effects related to lowering of LDL cholesterol levels and effects independent of the lowering of LDL cholesterol levels. The latter effects are referred to as pleiotropic.
Laurie G, Futterman, Louis, Lemberg
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Downward causation and vertical pleiotropy
Behavioral and Brain Sciences, 2023Abstract In discussing the relationship between genetically influenced differences and educational attainment (EA), Burt employs the concept of downward causation. I note the similarities between Burt's concept of downward causation and the sociogenomics concept of vertical pleiotropy and argue that her discussion of downward causation introduces an
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Antagonistic Pleiotropy in Human Disease
Journal of Molecular Evolution, 2019Between the 1930s and 1950s, scientists developed key principles of population genetics to try and explain the aging process. Almost a century later, these aging theories, including antagonistic pleiotropy and mutation accumulation, have been experimentally validated in animals.
Konstantinos Voskarides +2 more
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Pleiotropy in Aggressive Prostate Cancer?
European Urology, 2015Prostate cancer (PCa) is a heterogeneous disease, and covers a wide variety of clinical phenotypes, including both indolent disease and highly aggressive tumours that metastasise rapidly and cause significant morbidity and mortality. It would be of great value to understand and to be able to predict these differing outcomes and thus diagnose and ...
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Pleiotropy as a mechanism to stabilize cooperation
Nature, 2004Most genes affect many traits. This phenomenon, known as pleiotropy, is a major constraint on evolution because adaptive change in one trait may be prevented because it would compromise other traits affected by the same genes. Here we show that pleiotropy can have an unexpected effect and benefit one of the most enigmatic of adaptations--cooperation. A
Foster, Kevin R. +4 more
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Clinical implications for statin pleiotropy
Current Opinion in Lipidology, 2005Atherosclerosis is a multi-factorial condition involving dyslipidemia that can result in cardiovascular disease. Statins are potent inhibitors of cholesterol biosynthesis, and in clinical trials, statins have been shown to be beneficial in the primary and secondary prevention of coronary heart disease.
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Pleiotropy and the evolution of floral integration
New Phytologist, 2015SummaryFloral traits often show correlated variation, both within and across species. One explanation for this pattern of floral integration is that different elements of floral phenotypes are controlled by the same genes, that is, that the genetic architecture is pleiotropic.
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Conserved pleiotropy of an ancient plant homeobox gene uncovered by cis-regulatory dissection
Cell, 2021Zachary Lippman +2 more
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