Results 231 to 240 of about 65,328 (279)

Association of Inflammatory Proteins with Neuropathic Pain: A Two-Sample Bidirectional Mendelian Randomization. [PDF]

J Pain Res
Zhong J, Li H, Huang C, Zhang P, Pang X, Luo Z, Li C.   +6 more
europepmc   +1 more source

A two-stage GAN-based instrumental variable method for causal analysis of omics data. [PDF]

Brief Bioinform
Zhou Y, Geng P, Zhang S, Jin W, Chen L, Xiao F, Li Z, Lu Q.   +7 more
europepmc   +1 more source

Application of Mendelian randomization to appraise causality in relationships between the gut microbiome and cancer

Dawes A, Hatcher C, McKinlay A, Wade K.
europepmc   +1 more source

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Fibrillin protein pleiotropy: Acromelic dysplasias

Matrix Biology, 2019
The fibrillins are large extracellular matrix molecules that polymerize to form microfibrils. Fibrillin microfibrils are distinctive architectural elements that are both ubiquitous in the connective tissue space and also unique, displaying tissue-specific patterns.
Lynn Y, Sakai, Douglas R, Keene
openaire   +2 more sources

Statin Pleiotropy: Fact or Fiction?

American Journal of Critical Care, 2004
Accumulating evidence from clinical trials and basic research indicates that statin therapy favorably influences a number of diverse clinical events through both effects related to lowering of LDL cholesterol levels and effects independent of the lowering of LDL cholesterol levels. The latter effects are referred to as pleiotropic.
Laurie G, Futterman, Louis, Lemberg
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Downward causation and vertical pleiotropy

Behavioral and Brain Sciences, 2023
Abstract In discussing the relationship between genetically influenced differences and educational attainment (EA), Burt employs the concept of downward causation. I note the similarities between Burt's concept of downward causation and the sociogenomics concept of vertical pleiotropy and argue that her discussion of downward causation introduces an
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Antagonistic Pleiotropy in Human Disease

Journal of Molecular Evolution, 2019
Between the 1930s and 1950s, scientists developed key principles of population genetics to try and explain the aging process. Almost a century later, these aging theories, including antagonistic pleiotropy and mutation accumulation, have been experimentally validated in animals.
Sean G. Byars, Konstantinos Voskarides
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Pleiotropy in Aggressive Prostate Cancer?

European Urology, 2015
Prostate cancer (PCa) is a heterogeneous disease, and covers a wide variety of clinical phenotypes, including both indolent disease and highly aggressive tumours that metastasise rapidly and cause significant morbidity and mortality. It would be of great value to understand and to be able to predict these differing outcomes and thus diagnose and ...
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Clinical implications for statin pleiotropy

Current Opinion in Lipidology, 2005
Atherosclerosis is a multi-factorial condition involving dyslipidemia that can result in cardiovascular disease. Statins are potent inhibitors of cholesterol biosynthesis, and in clinical trials, statins have been shown to be beneficial in the primary and secondary prevention of coronary heart disease.
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