Results 211 to 220 of about 50,540 (257)

From paradox to biology: shared genetic architecture underlies the inverse association between smoking and Sjögren's disease. [PDF]

Rheumatology (Oxford)
van der Merwe S, Zuckerman B, Liu W, Cheng W, Zhao SS.   +4 more
europepmc   +1 more source

Hydrocalumite‐Like Material Induces Early Osteogenic Priming and ECM Remodeling Without Effective Mineralization in Preosteoblasts

Journal of Biomedical Materials Research Part A, Volume 114, Issue 11, November 2026.
ABSTRACT Hydrocalumite‐like phases, belonging to the layered double hydroxide family, are potential biomaterials for bone repair; however, their cellular effects remain incompletely understood. Here, we evaluated a hydrocalumite‐like material of composition [Ca2Al(OH)₆]Cl·nH2O (abbreviated Ca2Al–Cl) in preosteoblastic MC3T3‐E1 cells, assessing ...
C. J. da Costa Fernandes, G. S. de Almeida, M. Pires Figueiredo, V. R. L. Constantino, W. F. Zambuzzi   +4 more
wiley   +1 more source

Genetically predicted circulating polyunsaturated fatty acids and Crohn's disease susceptibility: A two-sample mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhu T, Hu Q, Zhu K.
europepmc   +1 more source

Breeding for multi‐stress resilience in crops: Myth or possibility?

PLANTS, PEOPLE, PLANET, Volume 8, Issue 6, Page 1968-1977, November 2026.
Climate change threatens millions of farmers worldwide by exposing crops to multiple concurrent or sequential environmental stresses such as drought, heat, waterlogging, and diseases. Although crops have long been selected under naturally occurring multi‐stress conditions, breeding pipelines largely focus on optimal or single‐stress environments ...
Hamid Khazaei, Ian C. Dodd, Rodomiro Ortiz   +2 more
wiley   +1 more source

Determinants of functional burden pleiotropy and gene dosage responses across human traits. [PDF]

Nat Commun
Kazem S, Kumar K, Yang J, Benitiere F, Huguet G, Mollon J, Renne T, Schultz LM, Knowles EEM, Engchuan W, Shanta O, Thiruvahindrapuram B, MacDonald JR, Greenwood CMT, Scherer SW, Almasy L, Sebat J, Glahn DC, Dumas G, Jacquemont S.   +19 more
europepmc   +1 more source

Live Fast, Die Old: Lowering Insulin Signalling During Development Can Speed Growth, Increase Reproduction and Lifespan, but Impair Environmental Sensing and Harm Offspring in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 11, November 2026.
Developmental reduction of insulin/IGF‐1 signalling via daf‐2 RNAi accelerates development, increases early reproduction, fitness, and lifespan in C. elegans, but compromises environmental sensing. Reduced IIS promotes inappropriate offspring dauer entry and delays recovery from developmental arrest.
Sara D. Irish, Annabel Kimberley, Peter Lenart, Hanne Carlsson, Anna Braybrooke, Benjamin Towbin, Simone Immler, Alexei A. Maklakov   +7 more
wiley   +1 more source

Exploratory bidirectional Mendelian randomisation analysis of cerebrospinal fluid metabolites associated with cerebral palsy and epilepsy. [PDF]

BMJ Paediatr Open
Mao L, Cui T, Liu Y, Chen X, Xu K.
europepmc   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source