Causal insights into how NAFLD progression drives abdominal aortic aneurysm: A bidirectional MR study integrating genetic and multi-omics profiling. [PDF]
Medicine (Baltimore)Xi R +6 more
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A Retrospective Analysis of Human Angiotensin II Receptor Blockers (ARB) Pharmacokinetics, Dosages and C<sub>max</sub> Values for the Experimental Modelling of Pleiotropic and Supratherapeutic Activities. [PDF]
Basic Clin Pharmacol ToxicolEvans A, Bernatchez P.
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Genetic predisposition to smoking and the risk of Carpal Tunnel Syndrome: a mendelian randomization study. [PDF]
Clinics (Sao Paulo)Zeng Q +5 more
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Association between coffee consumption and the risk of thyroid cancer: A Mendelian randomization study. [PDF]
Medicine (Baltimore)Wen W, Xu D, Li X.
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A two-sample bidirectional Mendelian randomization study on gut microbiota, dental caries, and toothache. [PDF]
Medicine (Baltimore)Zhang L, Zheng X, Xia J, Guo L, Yang S.
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Pleiotropy and Facilitation of Local Adaptation in the Silverleaf Sunflower Helianthus argophyllus. [PDF]
Genome Biol EvolOkinedo UE, Moyers BT.
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Pleiotropy and the Preservation of Perfection
Science, 1998A mathematical model is presented in which a single mutation can affect multiple phenotypic characters, each of which is subject to stabilizing selection. A wide range of mutations is allowed, including ones that produce extremely small phenotypic changes.
D, Waxman, J R, Peck
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On the definition and measurement of pleiotropy
Trends in Genetics, 2013Pleiotropy, a 103-year-old concept [1], refers to the phenomenon of one mutation affecting multiple traits. Compared with the fundamental importance of pleiotropy in genetics, development, evolution, and medicine, our empirical knowledge of the prevalence and mechanism of pleiotropy is scarce [2].
Jianzhi, Zhang, Gunter P, Wagner
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Pleiotropy of a Stickler syndrome genotype
European Journal of Ophthalmology, 2021Purpose: To report a case of pleiotropy in the COL2A1 gene typically associated with Stickler Syndrome Type 1. Observations: A patient with a confirmed mutation of the COL2A1 gene presented with an isolated retinitis pigmentosa ...
Ahmad Baiyasi +3 more
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Pleiotropy, a situation in which a single gene influences multiple phenotypic traits, can arise in a variety of ways. This paper discusses possible underlying mechanisms and proposes a classification of the various phenomena involved.
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