Results 191 to 200 of about 65,328 (279)

DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization

Addiction Biology, Volume 31, Issue 5, May 2026.
This study employed integrative Mendelian Randomization analysis to identify 10 drug‐targetable genes with altered expression in alcohol dependence. Colocalization evidence suggests shared causal variants. Crucially, DNA methylation at specific sites (cg07437263, cg05102552) mediates risk by upregulating the protective gene CDK5R1 (63.92%) and ...
Fuyuan Deng, Junsheng Peng, Siran Lai, Guangpeng Zhang, Miaomiao Li, Yuxin Huang, Mi Yuan, Gaolei Yao, Peiming Zhang, Liming Lu   +9 more
wiley   +1 more source

Mendelian randomization analysis reveals a shared protective role of gut microbiota genus Alloprevotella in spontaneous abortion and rheumatoid arthritis. [PDF]

Medicine (Baltimore)
Ding X, Zhao H, Ma Y, Zhao Y, Zheng M, Chen X, Jin L, Du T, Jiang Y, Zhao X.   +9 more
europepmc   +1 more source

Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population: A Mendelian Randomization Study

Cancer Science, Volume 117, Issue 5, Page 1446-1454, May 2026.
Our Mendelian Randomization analysis provides evidence supporting a causal association between genetic predisposition to T2D, independent of BMI, and an increased risk of pancreatic cancer in the Japanese population, corroborating findings from observational studies.
Yingsong Lin, Haruki Sasado, Naoki Sasahira, Makoto Ueno, Hiroshi Ishii, Naoto Egawa, Yasushi Adachi, Masato Ozaka, Satoshi Kobayashi, Yuriko N. Koyanagi, Sayaka Yamamoto, Hidemi Ito, Akira Narita, Mika Sakurai‐Yageta, Takuji Okusaka, Aya Kuchiba, Teruhiko Yoshida, Fumihiko Matsuda, Yoichiro Kamatani, Shiori Nakano, Taiki Yamaji, Norie Sawada, Aya Kadota, Kiyonori Kuriki, Takeshi Watanabe, Nobuo Fuse, Kengo Kinoshita, Naoki Nakaya, Yoichi Sutoh, Yayoi Otsuka‐Yamasaki, Kozo Tanno, Ken Suzuki, Toshimasa Yamauchi, Takashi Kadowaki, BioBank Japan, Motoki Iwasaki, Sho Nakamura, Atsushi Hozawa, Atsushi Shimizu, Shogo Kikuchi, Masahiro Nakatochi, Keitaro Matsuo   +41 more
wiley   +1 more source

Sarcopenia-related traits and erectile dysfunction: a bi-directional Mendelian randomization study. [PDF]

Sex Med
Jianxin X, Wensong W, Dengpan F, Yiwei W, Fangmin C.   +4 more
europepmc   +1 more source

The Genetic Origin of Uneven Cognitive Profiles in Heritable Neurodevelopmental Conditions and Individual Differences: Computational Investigations

Developmental Science, Volume 29, Issue 3, May 2026.
ABSTRACT While the heterogeneity and co‐occurrence of heritable neurodevelopmental conditions such as autism, attention deficit hyperactivity disorder (ADHD), and dyslexia remain issues of debate, these conditions are nevertheless all characterised by uneven cognitive profiles exhibiting strengths and weaknesses.
Maitrei Kohli, George Magoulas, Michael S. C. Thomas   +2 more
wiley   +1 more source

Causal associations between ankylosing spondylitis and cardiovascular disease: a mendelian randomization analysis. [PDF]

Clinics (Sao Paulo)
Zhou L, Tang Y, Jiang J.
europepmc   +1 more source

Causal role of genetically predicted impairment of branched‐chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3849-3860, May 2026.
Abstract Background Elevated branched‐chain amino acids (BCAAs; leucine, valine, isoleucine) are linked to type 2 diabetes (T2D) risk, characterised by defective insulin secretion in pancreatic β‐cell and peripheral insulin resistance. Causative interaction between BCAA metabolism and these two diabetic pathogenesis remains unclear.
Xiangyu Zhou, Jiawen Lu, Zhenqian Wang, Kenneth King‐Yip Cheng, Gloria Hoi‐Yee Li   +4 more
wiley   +1 more source

Corrigendum: Genetic overlap and causality between COVID-19 and multi-site chronic pain: the importance of immunity

Frontiers in Immunology
Yanjing Chen, Ping Liu, Zhiyi Zhang, Yingling Ye, Sijie Yi, Chunhua Fan, Wei Zhao, Jun Liu   +7 more
doaj   +1 more source

The Genetic Link Between Primary Immune Thrombocytopenia and Depression/Anxiety Disorders: A Two-Sample Mendelian Randomization Study. [PDF]

J Clin Lab Anal
Jiang L, Zhao YJ, Han SQ, Yan ZY, Liu XG.   +4 more
europepmc   +1 more source

Evaluating the Impact of Putative Metformin Targets on Cancer Outcomes: A Drug‐Target Mendelian Randomization Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4091-4099, May 2026.
ABSTRACT Aims Observational studies show metformin use associated with lower cancer risk, although experimental evidence is inconsistent. To provide genetic validation for repositioning of metformin in cancer prevention, we assessed genetically proxied effects of putative metformin targets on cancer outcomes using a drug‐target Mendelian randomization (
Xingyu Shen, Shan Luo, Jie Zheng, Celine Sze Ling Chui, Ian Chi Kei Wong, Eric Yuk Fai Wan, Catherine Mary Schooling, Shiu Lun Au Yeung   +7 more
wiley   +1 more source