Results 141 to 150 of about 3,466 (159)

In vitro approaches to study centriole and cilium function in early mouse embryogenesis

Voelkl I, Civetta T, Egg M, Huber M, Feng S, Dammermann A, Buecker C.   +6 more
europepmc   +1 more source

CenSegNet: a generalist high-throughput deep learning framework for centrosome phenotyping at spatial and single-cell resolution in heterogeneous tissues

Cheng J, Fan K, Bailey M, Du X, Jena R, Savva C, Gou M, Cutress R, Beers S, Cai X, Elias S.   +10 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis

Nature Genetics, 2005
The polo-like kinase Plk4 (also called Sak) is required for late mitotic progression, cell survival and postgastrulation embryonic development. Here we identified a phenotype resulting from Plk4 haploinsufficiency in Plk4 heterozygous cells and mice. Plk4+/- embryonic fibroblasts had increased centrosomal amplification, multipolar spindle formation and
Michael A, Ko, Carla O, Rosario, John W, Hudson, Sarang, Kulkarni, Aaron, Pollett, James W, Dennis, Carol J, Swallow   +6 more
openaire   +2 more sources

TEC kinase stabilizes PLK4 to promote liver cancer metastasis

Cancer Letters, 2022
Aberrated PLK4 expression has been reported in different malignancies and causes centrosome amplification, aneuploidy, and genomic instability. However, the mechanism by which PLK4 is regulated in carcinogenesis remains not fully characterised. Here, we showed that PLK4 was overexpressed in human HCC and overexpression of PLK4 predicted poorer patient ...
Sai-Fung Yeung, Yuan Zhou, Wenjun Zou, Wing-Lim Chan, Yick Pang Ching   +4 more
openaire   +2 more sources

PLK4: a promising target for cancer therapy

Journal of Cancer Research and Clinical Oncology, 2019
Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates centriole duplication. PLK4 deregulation causes centrosome number abnormalities, mitotic defects, chromosomal instability and, consequently, tumorigenesis. Therefore, PLK4 has emerged as a therapeutic target for the treatment of multiple cancers.
Yi Zhao, Xin Wang
openaire   +2 more sources

The Polo kinase Plk4 functions in centriole duplication

Nature Cell Biology, 2005
The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division. By contrast, the functions of other mammalian Polo family members remain largely unknown.
Habedanck, Robert, Stierhof, York-Dieter, Wilkinson, Christopher J., Nigg, Erich A.   +3 more
openaire   +3 more sources

PLK4: a link between centriole biogenesis and cancer

Expert Opinion on Therapeutic Targets, 2017
Polo like kinase (PLK) is known to play a pivotal role in various cell cycle processes to perpetuate proper division and growth of the cells. Polo like kinase-4 (PLK4) is one such kinase that appears in low abundance and plays a well-characterized role in centriole duplication. PLK4 deregulation (i.e.
Radhika Radha, Maniswami, Seema, Prashanth, Archana Venkataramana, Karanth, Sindhu, Koushik, Hemalatha, Govindaraj, Ramesh, Mullangi, Sriram, Rajagopal, Sooriya Kumar, Jegatheesan   +7 more
openaire   +2 more sources

Mechanisms of Plk4 haploinsufficiency in hepatocellular carcinogenesis

Journal of Clinical Oncology, 2009
11100 Background: The pathogenesis of hepatocellular carcinoma (HCC) is multifactorial and includes genetic predisposition, though the precise nature of the latter is as yet poorly understood. Mice heterozygous for the polo like kinase Plk4 develop spontaneous HCC and human HCC cases show a high rate of LOH (loss of heterozygosity) at the Plk4 locus.
P. Wu, C. Rosario, J. Paderova, R. Gladdy, M. Ko, J. Squire, J. Dennis, C. Swallow   +7 more
openaire   +1 more source

Cell fate in the Hand of Plk4

Nature Cell Biology, 2007
The transcription factor Hand1 is required for cell-fate determination during placental development. Recent work shows that release of Hand1 from the nucleolus controls differentiation of trophoblast stem cells into trophoblast giant cells, and this switch is controlled by the antagonistic activities of HICp40 and Polo-like kinase-4 (Plk4).
Marvin E. Tanenbaum, René H. Medemao
openaire   +1 more source

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

Nature Cell Biology, 2015
Aneuploidy is found in most solid tumours, but it remains unclear whether it is the cause or the consequence of tumorigenesis. Using Plk4 overexpression (PLK4OE) during epidermal development, we assess the impact of centrosome amplification and aneuploidy on skin development and tumorigenesis.
Sercin, Ozdemirhan, Larsimont, Jean-Christophe, Karambelas, Andrea E, Marthiens, Véronique, Moers, Virginie, Boeckx, Bram, Le Mercier, Marie, Lambrechts, Diether, Basto, Renata, Blanpain, Cédric   +9 more
openaire   +2 more sources