Results 61 to 70 of about 100,488 (302)

Lysine Decarboxylase with an Enhanced Affinity for Pyridoxal 5-Phosphate by Disulfide Bond-Mediated Spatial Reconstitution. [PDF]

PLoS ONE, 2017
Lysine decarboxylase (LDC) catalyzes the decarboxylation of l-lysine to produce cadaverine, an important industrial platform chemical for bio-based polyamides.
Hye-Young Sagong, Kyung-Jin Kim
doaj   +1 more source

Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]

, 2018
'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon, Van Der Straeten, Dominique   +1 more
core   +3 more sources

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Interphase centrosome organization by the PLP-Cnn scaffold is required for centrosome function

Journal of Cell Biology, 2015
Cnn and PLP directly interact at two defined sites to coordinate the cell cycle–dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability.
Dorothy A. Lerit, Holly A. Jordan, J. Poulton, C. Fagerstrom, B. Galletta, M. Peifer, N. Rusan   +6 more
semanticscholar   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Metabolomics coupled with multivariate data and pathway analysis on potential biomarkers in cholestasis and intervention effect of Paeonia lactiflora Pall.

Frontiers in Pharmacology, 2016
Background: The dried root of Paeonia lactiflora Pall. (PLP) is a classical Chinese herbal medicine that has been used to treat hepatic disease for thousands of years.
Xiao eMa, Xiao eMa, Yong-Hui eChi, Ming eNiu, Yun eZhu, Yan-Ling eZhao, Zhe eChen, Zhe eChen, Jia-Bo eWang, Cong-En eZhang, Cong-En eZhang, Jian-Yu eLi, Li-Fu eWang, Man eGong, Shi-Zhang eWei, Shi-Zhang eWei, Chang eChen, Chang eChen, Lu eZhang, Lu eZhang, Ming-Quan eWu, Ming-Quan eWu, Xiao-He eXiao   +22 more
doaj   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

Polphylipoprotein-induced autophagy mechanism with high performance in photodynamic therapy

Communications Biology, 2023
Polphylipoprotein (PLP) is a recently developed nanoparticle with high biocompatibility and tumor selectivity, and which has demonstrated unprecedentedly high performance photosensitizer in photodynamic therapy (PDT) and photodynamic diagnosis.
Atsushi Taninaka, Hiromi Kurokawa, Mayuka Kamiyanagi, Takahiro Ochiai, Yusuke Arashida, Osamu Takeuchi, Hirofumi Matsui, Hidemi Shigekawa   +7 more
doaj   +1 more source

A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer

Frontiers in Pharmacology, 2021
Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) that mediate T-cell immune responses. Breast cancer is one of the most commonly diagnosed diseases and its mortality rate is higher than any other cancer in both ...
Jiafeng Gao, Yi-Nan Zhang, Jingwen Cui, Jiatong Zhang, Yuexiang Ming, Zhihui Hao, Zhihui Hao, Huihao Xu, Nan Cheng, Di Zhang, Yipeng Jin, Degui Lin, Jiahao Lin, Jiahao Lin   +13 more
doaj   +1 more source