Results 71 to 80 of about 100,488 (302)
Conformational change of organic cofactor PLP is essential for catalysis in PLP-dependent enzymes
BMB Reports, 2022 Pyridoxal 5’-phosphate (PLP)-dependent enzymes are ubiquitous, catalyzing various biochemical reactions of approximately 4% of all classified enzymatic activities. They transform amines and amino acids into important metabolites or signaling molecules and are important drug targets in many diseases.
Ho-Phuong-Thuy Ngo +8 more
openaire +1 more source
Advanced Science, EarlyView.This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He +17 more
wiley +1 more source
Nanoscale Research Letters, 2017 Herein, folic acid (FA) conjugated Poly(d,l-lactide-co-glycolide) (PLGA)-lipid composites (FA-PL) were developed as nanocarriers for the targeted delivery of insoluble anti-cancer drug paclitaxel (PTX), resulting FA-PLP nanoparticles.
Haiyan Wang, Weizhong Sheng
doaj +1 more source
Pyridoxal phosphate synthases PdxS/PdxT are required for Actinobacillus pleuropneumoniae viability, stress tolerance and virulence. [PDF]
PLoS ONE, 2017 Pyridoxal 5'-phosphate (PLP) is an essential cofactor for numerous enzymes involved in a diversity of cellular processes in living organisms. Previous analysis of the Actinobacillus pleuropneumoniae S-8 genome sequence revealed the presence of pdxS and ...
Fang Xie +8 more
doaj +1 more source
Optimal time-decay estimates for the compressible navier-stokes equations in the critical l p framework [PDF]
, 2016 The global existence issue for the isentropic compressible Navier-Stokes equations in the critical regularity framework has been addressed in [7] more than fifteen years ago.
Danchin, Raphaël, Xu, Jiang
core +2 more sources
Advanced Science, EarlyView.The unique lamellar structure of the eutectic alloy promotes selective oxidation of Al initially, while lattice distortion‐induced diffusion suppression slows oxide growth during steady state. Combining these strategies, a Multi‐Principal Element Alloy with excellent oxidation resistance at 1200℃ was designed.
Xinyu Zhang +6 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2019 The B6 vitamer pyridoxal 5′-phosphate (PLP) is a co-factor for proteins and enzymes that are involved in diverse cellular processes. Therefore, PLP is essential for organisms from all kingdoms of life.
Björn Richts +2 more
doaj +1 more source
Subtle myelin defects in PLP‐null mice
Glia, 2006 AbstractThis study explores subtle defects in the myelin of proteolipid protein (PLP)‐null mice that could potentially underlie the functional losses and axon damage known to occur in this mutant and in myelin diseases including multiple sclerosis. We have compared PLP‐null central nervous system (CNS) myelin with normal myelin using ultrastructural ...
Rosenbluth, J. +3 more
openaire +4 more sources
PLoS ONE, 2014 In the central nervous system, lipid-protein interactions are pivotal for myelin maintenance, as these interactions regulate protein transport to the myelin membrane as well as the molecular organization within the sheath. To improve our understanding of
Hande Ozgen +7 more
semanticscholar +1 more source
Australian Journal of Social Issues, EarlyView.ABSTRACT The Australian paid parental leave (PPL) government scheme aims to support working parents through financial assistance and the promotion of gender equality in caregiving responsibilities. However, the scheme's implementation has been critiqued for its gendered design, which marginalises fathers and reinforces traditional gender roles.
Lily Lewington +2 more
wiley +1 more source