Results 101 to 110 of about 212,295 (303)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Into the Deep (Sequence) of the Foot-and-Mouth Disease Virus Gene Pool: Bottlenecks and Adaptation during Infection in Naïve and Vaccinated Cattle

Pathogens, 2020
Foot-and-mouth disease virus (FMDV) infects hosts as a population of closely related viruses referred to as a quasispecies. The behavior of this quasispecies has not been described in detail in natural host species. In this study, virus samples collected
Ian Fish, Carolina Stenfeldt, Rachel M. Palinski, Steven J. Pauszek, Jonathan Arzt   +4 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Contact Challenge of Cattle with Foot-and-Mouth Disease Virus Validates the Role of the Nasopharyngeal Epithelium as the Site of Primary and Persistent Infection

mSphere, 2018
The pathogenesis of foot-and-mouth disease virus (FMDV) in cattle was investigated through early and late stages of infection by use of an optimized experimental model for controlled contact exposure. Time-limited exposure of cattle to FMDV-infected pigs
Carolina Stenfeldt, Ethan J. Hartwig, George R. Smoliga, Rachel Palinski, Ediane B. Silva, Miranda R. Bertram, Ian H. Fish, Steven J. Pauszek, Jonathan Arzt   +8 more
doaj   +1 more source

Water loss in horticultural products. Modelling, data analysis and theoretical considerations [PDF]

, 2010
The water loss of individual fruit (melon, plum and mandarin) was analysed using the traditional diffusion based approach and a kinetic approach. Applying simple non linear regression, both approaches are the same, resulting in a quite acceptable ...
Dos-Santos, N., Fernandez-Trujillo, J.P., Jacob, S., Pagan, E., Perez Pastor, A., Schouten, R.E., Tijskens, L.M.M., Vangdal, E.   +7 more
core   +2 more sources

Effect of micronutrients foliar supplementation on the production and eminence of plum (Prunus domestica L.)

, 2020
Poor soil fertility due to continuous depletion of micronutrients is a major problem for the production of Prunus domestica L. Low level of soil organic matter and calcareous parent material decrease the bioavailability of these micronutrients to plum ...
Rafiullah, M. Tariq, Farmanullah Khan, A. Shah, S. Fahad, F. Wahid, J. Ali, Muhammad Adnan, M. Ahmad, M. Irfan, M. Zafar-ul-Hye, M. Battaglia, Tayebeh Zarei, I. Salim, R. Datta, Hafeez-u-Rehman, Subhan Danish   +16 more
semanticscholar   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Inference to the Best Explanation Made Incoherent [PDF]

, 2017
Defenders of Inference to the Best Explanation claim that explanatory factors should play an important role in empirical inference. They disagree, however, about how exactly to formulate this role.
Climenhaga, Nevin
core   +2 more sources

BBN PLUM [PDF]

Proceedings of the 3rd conference on Message understanding - MUC3 '91, 1991
Perhaps the most important facts about our participation in MUC-3 reflect our starting point and goals. In March, 1990, we initiated a pilot study on the feasibility and impact of applying statistical algorithms in natural language processing. The experiments were concluded in March, 1991 and lead us to believe that statistical approaches can ...
Ralph Weischedel, Damaris Ayuso, Sean Boisen, Robert Ingria, Jeff Palmucci   +4 more
openaire   +1 more source