Disclosure of Potential Therapeutic Targets in Plumbagin for Treating Osteosarcoma [PDF]
Biomedical Engineering and Computational BiologyOsteosarcoma is one of most malignant bone tumors in children, characterized by high recurrence and metastasis. Plumbagin refers to a bioactive compound that is isolated the herb plant of from Plumbagozeylanica zeylanica L.
Rubiao Qiu +8 more
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Plumbagin Protects Diabetogenic Cataract Formation by Mitigating Lens Aldose Reductase and Oxidative Stress [PDF]
Journal of PharmacopunctureObjectives: The polyol pathway plays an important pathophysiological role in diabetic-related ocular complications, including cataracts, one of the major causes of ocular blindness.
Apurva Yadav +4 more
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The Occurrence, Uses, Biosynthetic Pathway, and Biotechnological Production of Plumbagin, a Potent Antitumor Naphthoquinone [PDF]
MoleculesPlumbagin is an important naphthoquinone with potent anticancer properties besides multitudinous uses in healthcare. It is produced in a limited number of species and families but mostly in the roots of Plumbaginaceae family members.
Polavarapu B. Kavi Kishor +6 more
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Unveiling the power of plumbagin: revitalizing exhausted T cells to combat tongue cancer [PDF]
Cancer Cell InternationalBackground Tongue squamous cell carcinoma (TSCC), the most common form of oral cancer, has a poor prognosis associated with immune escape due to T cell exhaustion within the tumor microenvironment (TME).
Rongrong Zhang +4 more
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Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression
Journal of Pharmacological Sciences, 2015 Plumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our group, which demonstrated the effectiveness of plumbagin against glioma cells, we further ...
Mingshan Niu +2 more
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Antibiofilm activity of Plumbagin against Staphylococcus aureus [PDF]
Scientific ReportsIn chronic infections caused by Staphylococcus aureus, biofilm is a major virulence factor. In Staphylococcus aureus biofilms, bacteria are embedded in a matrix of extracellular polymeric substances and are highly tolerant to antimicrobial drugs. However,
Songtao Bie +9 more
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Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the inhibitory effect and mechanism of temozolomide on migration and invasion of U251 human glioma cells enhanced by plumbagin.
CAI Wei +5 more
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The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation. [PDF]
PLoS ONE, 2012 Drug-induced haploinsufficiency (DIH) in yeast has been considered a valuable tool for drug target identification. A plant metabolite, plumbagin, has potent anticancer activity via reactive oxygen species (ROS) generation. However, the detailed molecular
Ju-Hee Lee +6 more
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Phytochemical evaluation of Plumbago zeylanica roots from Indonesia and assessment of its plumbagin concentration [PDF]
Folia Medica, 2022 Introduction: Plumbago zeylanica grows widely in many tropical countries. In Indonesia, this plant, known as Daun Encok, has some beneficial effects on human health. Aim: This exploration study aimed to identify the plumbagin compound in P ...
Mitayani Purwoko +3 more
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Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2.
PLoS ONE, 2011 Plumbagin, a quinonoid found in the plants of the Plumbaginaceae, possesses medicinal properties. In this study we investigated the anti-proliferative and apoptotic activity of plumbagin by using two human colonic cancer cell lines, HT29 and HCT15.
Bharathi Raja Subramaniya +6 more
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