Results 11 to 20 of about 7,364 (206)
Plumbagin Modulates Leukemia Cell Redox Status [PDF]
Molecules, 2014 Plumbagin is a plant naphtoquinone exerting anti-cancer properties including apoptotic cell death induction and generation of reactive oxygen species (ROS).
François Gaascht +5 more
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Inhibition of Mycobacterial Growth by Plumbagin Derivatives [PDF]
Chemical Biology & Drug Design, 2010 Electron transport and respiratory pathways are active in both latent and rapidly growing mycobacteria and remain conserved in all mycobacterial species. In mycobacteria, menaquinone is the sole electron carrier responsible for electron transport. Menaquinone biosynthesis pathway is found to be essential for the growth of mycobacteria.
Mathew, Ritta +5 more
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Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats
Cellular Physiology and Biochemistry, 2015 Background/Aims: Our previous studies have shown that plumbagin effectively inhibits hepatic stellate cell (HSC) proliferation. Thus, plumbagin-mediated anti-fibrotic effects in vivo merit further investigation.
Yanfei Wei +7 more
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A role of
Journal of Biomedical Science, 2010 Plumbagin is found in many herbal plants and inhibits the growth of various bacteria. Escherichia coli strains are relatively resistant to this drug. The mechanism of resistance is not clear. Previous findings showed that plumbagin treatment triggered up-
Chen Tai-Hung +6 more
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Plumbagin modulates RANKL-induced osteoclast and osteoblast differentiation
Phytomedicine Plus, 2023 Background: Bone remodeling is a balanced, dynamic function of two counteractive processes: osteoblasts-mediated bone formation and osteoclasts-dependent bone resorption. An imbalance between these two processes causes bone diseases.
Soni Ghumnani +4 more
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Drug Design, Development and Therapy, 2019 Tingting Li, Mengjiao Lv, Xiaohua Chen, Yongsheng Yu, Guoqing Zang, Zhenghao TangDepartment of Infectious Disease, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, People’s Republic of ChinaPurpose ...
Li T +6 more
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Antioxidant Activities of Plumbagin and Its Cu (II) Complex [PDF]
Bioinorganic Chemistry and Applications, 2011 Plumbagin and its Cu (II) complex [Cu (plumbagin)2]·H2O have been synthesized, and their antioxidant activities towards the inhibitory effect on DPPH free radical, reducing power, total antioxidant capacity, and inhibition on lipid peroxidation were ...
Mingxiong Tan +4 more
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Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review
The American Journal of Chinese Medicine, 2017 It has been shown that plumbagin, a bioactive naphthoquinone isolated from three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae, definitively exhibits anticancer potential in diverse cancer cells both in vitro and in vivo. Plumbagin shows antineoplastic effects via multi-channel molecular mechanisms, including the induction of ...
Yuling, Liu +4 more
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Molecules, 1999 Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) (CAS Reg. No. 481-42-5) was isolated from the bark of Diospyros olen (Ebenaceae) via an antibiotic guided biological assay using the bacterium Pseudomonas solanacearum. D. olen bark, collected in New Caledonia, was extracted with dichloromethane and components separated by flash chromatography on silica.
Philip Evans +3 more
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Improvement of Learning and Memory of Mice by Plumbagin
Journal of Pharmaceutical Technology, Research and Management, 2016 Roots of Plumbago zeylanica have been reported to improve learning and memory of mice, but the effect of plumbagin on learning and memory of mice and the possible mechanisms for its effect on memory have not been explored till date. So the present study was designed to evaluate the effect of plumbagin on learning and memory of Swiss young male albino ...
D Dhingra, S Parshad
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