Results 1 to 10 of about 959,542 (406)

Epigenetic memory in induced pluripotent stem cells. [PDF]

Nature, 2010
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues.
Aryee, MJ, Cahan, P, Cunniff, KC, Daley, GQ, Doi, A, Ehrlich, LIR, Feinberg, AP, Hanna, J, Hongguang, H, Irizarry, RA, Jaenisch, R, Ji, H, Jung, N, Kim, J, Kim, K, McKinney-Freeman, S, Murakami, P, Naveiras, O, Ng, K, Orkin, SH, Seita, J, Takeuchi, A, Weissleder, R, Weissman, IL, Wen, B, Yabuuchi, A, Yoon, TJ, Zhao, R   +27 more
core   +2 more sources

Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells [PDF]

Stem Cells International, 2016
A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved ...
Aoife Gowran, Marco Rasponi, Roberta Visone, Patrizia Nigro, Gianluca L. Perrucci, Stefano Righetti, Marco Zanobini, Giulio Pompilio   +7 more
doaj   +9 more sources

Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors [PDF]

, 2008
Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka   +6 more
openalex   +2 more sources

Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. [PDF]

, 2017
Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Chen, Di, Clark, Amander T, Gkountela, Sofia, Hennebold, Jon D, Liu, Wanlu, Orwig, Kyle E, Sosa, Enrique, Sukhwani, Meena   +7 more
core   +11 more sources

Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros

iScience, 2022
Summary: Less than 80 Sumatran rhinos (SR, Dicerorhinus sumatrensis) are left on earth. Habitat loss and limited breeding possibilities are the greatest threats to the species and lead to a continuous population decline.
Vera Zywitza, Silke Frahm, Norman Krüger, Anja Weise, Frank Göritz, Robert Hermes, Susanne Holtze, Silvia Colleoni, Cesare Galli, Micha Drukker, Thomas B. Hildebrandt, Sebastian Diecke   +11 more
doaj   +1 more source

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction

Scientific Reports, 2022
The northern white rhinoceros (NWR) is probably the earth’s most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Vera Zywitza, Ejona Rusha, Dmitry Shaposhnikov, Jorge Ruiz-Orera, Narasimha Telugu, Valentyna Rishko, Masafumi Hayashi, Geert Michel, Lars Wittler, Jan Stejskal, Susanne Holtze, Frank Göritz, Robert Hermes, Jichang Wang, Zsuzsanna Izsvák, Silvia Colleoni, Giovanna Lazzari, Cesare Galli, Thomas B. Hildebrandt, Katsuhiko Hayashi, Sebastian Diecke, Micha Drukker   +21 more
doaj   +1 more source

ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs

STAR Protocols, 2023
Summary: CRISPR-Cas9 technology coupled with human induced pluripotent stem cells allows precise disease modeling in pluripotent cells and subsequently derived specialized cell types.
Katarzyna A. Ludwik, Narasimha Telugu, Sandra Schommer, Harald Stachelscheid, Sebastian Diecke   +4 more
doaj   +1 more source

Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout

Stem Cell Research, 2022
T-Box Transcription Factor 18 is a member of the T-box family, encoding TBX18 protein. As a transcriptional repressor, it related to developmental processes of a majority of tissues and organs and plays crucial part in the embryonic development of ...
Qi Xu, Tiantian Zhao, Yongshuai Zhang, Wei Fan, Yuting Yan, Feng Lan   +5 more
doaj   +1 more source

Generation of a human embryonic stem cell line WAe009-A-79 carrying a long QT syndrome mutation in KCNQ1

Stem Cell Research, 2023
The voltage-gated potassium channel KvLQT1 encoded by KCNQ1 plays an important role in the repolarization of myocardial action potentials. KCNQ1 mutations can cause Long QT syndrome type 1 (LQT1), which is considered to be the most common causative gene ...
Hongyue Wang, Tianwei Guo, Feng Lan
doaj   +1 more source

Porcine OCT4 reporter system as a tool for monitoring pluripotency states

Journal of Animal Reproduction and Biotechnology, 2021
Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent
Seung-Hun Kim, Chang-Kyu Lee
doaj   +1 more source