Results 1 to 10 of about 147,835 (297)

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction

Scientific Reports, 2022
The northern white rhinoceros (NWR) is probably the earth’s most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Vera Zywitza, Ejona Rusha, Dmitry Shaposhnikov, Jorge Ruiz-Orera, Narasimha Telugu, Valentyna Rishko, Masafumi Hayashi, Geert Michel, Lars Wittler, Jan Stejskal, Susanne Holtze, Frank Göritz, Robert Hermes, Jichang Wang, Zsuzsanna Izsvák, Silvia Colleoni, Giovanna Lazzari, Cesare Galli, Thomas B. Hildebrandt, Katsuhiko Hayashi, Sebastian Diecke, Micha Drukker   +21 more
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Porcine OCT4 reporter system as a tool for monitoring pluripotency states

Journal of Animal Reproduction and Biotechnology, 2021
Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent
Seung-Hun Kim, Chang-Kyu Lee
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Absence of Rybp Compromises Neural Differentiation of Embryonic Stem Cells

Stem Cells International, 2016
Rybp (Ring1 and Yy1 Binding Protein) is a transcriptional regulator and member of the noncanonical polycomb repressive complex 1 with essential role in early embryonic development.
Gergo Kovacs, Viktoria Szabo, Melinda K. Pirity   +2 more
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Fish Pluripotent Stem-Like Cell Line Induced by Small-Molecule Compounds From Caudal Fin and its Developmental Potentiality

Frontiers in Cell and Developmental Biology, 2022
The technique of induced pluripotent stem cells has significant application value in breeding and preserving the genetic integrity of fish species. However, it is still unclear whether the chemically induced pluripotent stem cells can be induced from non-
Wenting Xu, Wenting Xu, Huajin Li, Huajin Li, Liangyue Peng, Liangyue Peng, Liyu Pu, Liyu Pu, Sijia Xiang, Sijia Xiang, Yue Li, Yue Li, Leiting Tao, Leiting Tao, Wenbin Liu, Wenbin Liu, Jinhui Liu, Jinhui Liu, Yamei Xiao, Yamei Xiao, Shaojun Liu, Shaojun Liu   +21 more
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Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies

Neural Regeneration Research, 2022
Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement therapies. Pluripotent stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected ...
Ignacio Rodriguez-Polo, Rüdiger Behr
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The alternative 3′ splice site of GPNMB may promote neuronal survival after neonatal hypoxic–ischemic encephalopathy injury

Ibrain, 2022
This study aimed to decipher the effect of glycoprotein nonmetastatic melanoma protein B (GPNMB) on neonatal hypoxic–ischemic encephalopathy (NHIE) and its potential molecular mechanism.
Guo‐Jiao Chen, Shan‐Shan Yan, Jing‐Han Zhang, Ji Zhang, Isaac Bul Deng, Rong He   +5 more
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Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros

iScience, 2022
Summary: Less than 80 Sumatran rhinos (SR, Dicerorhinus sumatrensis) are left on earth. Habitat loss and limited breeding possibilities are the greatest threats to the species and lead to a continuous population decline.
Vera Zywitza, Silke Frahm, Norman Krüger, Anja Weise, Frank Göritz, Robert Hermes, Susanne Holtze, Silvia Colleoni, Cesare Galli, Micha Drukker, Thomas B. Hildebrandt, Sebastian Diecke   +11 more
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ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs

STAR Protocols, 2023
Summary: CRISPR-Cas9 technology coupled with human induced pluripotent stem cells allows precise disease modeling in pluripotent cells and subsequently derived specialized cell types.
Katarzyna A. Ludwik, Narasimha Telugu, Sandra Schommer, Harald Stachelscheid, Sebastian Diecke   +4 more
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Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin

Haematologica, 2015
Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells.
Isabel Dorn, Katharina Klich, Marcos J. Arauzo-Bravo, Martina Radstaak, Simeon Santourlidis, Foued Ghanjati, Teja F. Radke, Olympia E. Psathaki, Gunnar Hargus, Jan Kramer, Martin Einhaus, Jeong Beom Kim, Gesine Kögler, Peter Wernet, Hans R. Schöler, Peter Schlenke, Holm Zaehres   +16 more
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DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. [PDF]

PLoS ONE, 2012
The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability.
Li Z Luo, Sailesh Gopalakrishna-Pillai, Stephanie L Nay, Sang-Won Park, Steven E Bates, Xianmin Zeng, Linda E Iverson, Timothy R O'Connor   +7 more
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