Results 1 to 10 of about 980,977 (401)
Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. [PDF]
, 2017 Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Chen, Di +7 more
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Pluripotency of induced pluripotent stem cells [PDF]
Journal of Animal Science and Biotechnology, 2012 Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) cells.
Kang Lan, Gao Shaorong
openaire +3 more sources
iScience, 2022 Summary: Less than 80 Sumatran rhinos (SR, Dicerorhinus sumatrensis) are left on earth. Habitat loss and limited breeding possibilities are the greatest threats to the species and lead to a continuous population decline.
Vera Zywitza +11 more
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Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction
Scientific Reports, 2022 The northern white rhinoceros (NWR) is probably the earth’s most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Vera Zywitza +21 more
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Editorial: Role of induced pluripotent stem cells (iPSCs) in regenerative medicine, disease modeling and drug discovery. [PDF]
Front Bioeng BiotechnolO'Connor KC +3 more
europepmc +3 more sources
ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs
STAR Protocols, 2023 Summary: CRISPR-Cas9 technology coupled with human induced pluripotent stem cells allows precise disease modeling in pluripotent cells and subsequently derived specialized cell types.
Katarzyna A. Ludwik +4 more
doaj +1 more source
Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout
Stem Cell Research, 2022 T-Box Transcription Factor 18 is a member of the T-box family, encoding TBX18 protein. As a transcriptional repressor, it related to developmental processes of a majority of tissues and organs and plays crucial part in the embryonic development of ...
Qi Xu +5 more
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Pluripotent stem cell lines [PDF]
Genes & Development, 2008 The derivation of human embryonic stem cells 10 years ago ignited an explosion of public interest in stem cells, yet this achievement depended on prior decades of research on mouse embryonic carcinoma cells and embryonic stem cells. In turn, the recent derivation of mouse and human induced pluripotent stem cells depended on the prior studies on mouse ...
Junying, Yu, James A, Thomson
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Stem Cell Research, 2023 The voltage-gated potassium channel KvLQT1 encoded by KCNQ1 plays an important role in the repolarization of myocardial action potentials. KCNQ1 mutations can cause Long QT syndrome type 1 (LQT1), which is considered to be the most common causative gene ...
Hongyue Wang, Tianwei Guo, Feng Lan
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Induced pluripotent stem cells are induced pluripotent stem cell-like cells [PDF]
The Journal of Biomedical Research, 2015 Gold is rare and precious, while pyrite (FeS2) is abundant and cheap. Pyrite is nicknamed fool's gold, since pyrite looks like gold and it is even shinier and brighter than gold. It is very difficult to recognize the differences between a real natural gold and a gold-like rock (pyrite) to non-professional persons[1], but we know that all that glitters ...
Song, Liting, Goldman, Emanuel
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