Results 141 to 150 of about 980,977 (401)

Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

Haematologica, 2012
Background Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells ...
Ladan Kobari, Frank Yates, Noufissa Oudrhiri, Alain Francina, Laurent Kiger, Christelle Mazurier, Shaghayegh Rouzbeh, Wassim El-Nemer, Nicolas Hebert, Marie-Catherine Giarratana, Sabine François, Alain Chapel, Hélène Lapillonne, Dominique Luton, Annelise Bennaceur-Griscelli, Luc Douay   +15 more
doaj   +1 more source

Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations [PDF]

, 2023
Chao Chen, Min‐Xin Guan
openalex   +1 more source

Haematopoietic stem and progenitor cells from human pluripotent stem cells

Nature, 2017
A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking embryonic development through stepwise exposure to morphogens, or by conversion of one differentiated cell type into another by enforced expression of master ...
Ryohichi Sugimura, D. Jha, Areum Han, C. Soria-Valles, Edroaldo L. Rocha, Yi-fen Lu, J. Goettel, J. Goettel, Erik Serrao, R. G. Rowe, Mohan Malleshaiah, Irene G. Wong, Patricia Sousa, Ted Zhu, Andrea Ditadi, G. Keller, A. Engelman, S. Snapper, S. Snapper, S. Snapper, Sergei Doulatov, G. Daley   +21 more
semanticscholar   +1 more source

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

Cell fiber-based three-dimensional culture system for highly efficient expansion of human induced pluripotent stem cells

Scientific Reports, 2017
Human pluripotent stem cells are a potentially powerful cellular resource for application in regenerative medicine. Because such applications require large numbers of human pluripotent stem cell-derived cells, a scalable culture system of human ...
Kazuhiro Ikeda, Shogo Nagata, Teru Okitsu, Shoji Takeuchi   +3 more
doaj   +1 more source

Engineered hematopoietic and immune cells derived from human pluripotent stem cells [PDF]

, 2023
Yun Chang, Sydney N. Hummel, Juhyung Jung, Gyuhyung Jin, Qing Deng, Xiaoping Bao   +5 more
openalex   +1 more source

Stemming retinal regeneration with pluripotent stem cells

Progress in Retinal and Eye Research, 2019
Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis pigmentosa (RP) and glaucoma. These diseases are all characterized by the degeneration of one or two retinal cell types that cannot regenerate spontaneously in humans ...
Zi-Bing Jin, Mei-Ling Gao, Wen-Li Deng, Kun-Chao Wu, Sunao Sugita, Michiko Mandai, Masayo Takahashi   +6 more
openaire   +2 more sources

Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways

Stem Cells, 2017
Pluripotent stem cells are a promising source of endothelial cells (ECs) for the treatment of vascular diseases. We have developed a robust protocol to differentiate human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs) into ECs ...
Aja Harding, E. Cortez-Toledo, Nataly L. Magner, J. Beegle, Dane Coleal-Bergum, D. Hao, Aijun Wang, J. Nolta, P. Zhou   +8 more
semanticscholar   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Induced pluripotent stem cells: advances to applications

Stem Cells and Cloning: Advances and Applications, 2009
Timothy J Nelson1, Almudena Martinez-Fernandez1, Satsuki Yamada1, Yasuhiro Ikeda2, Carmen Perez-Terzic1, Andre Terzic11Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA; 2Department of ...
Timothy J Nelson, Almudena Martinez-Fernandez, Satsuki Yamada, et al   +3 more
doaj