Results 141 to 150 of about 998,979 (405)

SILAC Proteomics of Planarians Identifies Ncoa5 as a Conserved Component of Pluripotent Stem Cells

Cell Reports, 2013
Planarian regeneration depends on the presence of pluripotent stem cells in the adult. We developed an in vivo stable isotope labeling by amino acids in cell culture (SILAC) protocol in planarians to identify proteins that are enriched in planarian stem ...
Alexander Böser, Hannes C.A. Drexler, Hanna Reuter, Henning Schmitz, Guangming Wu, Hans R. Schöler, Luca Gentile, Kerstin Bartscherer   +7 more
doaj   +1 more source

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. [PDF]

, 2019
In vitro gametogenesis is the process of making germline cells from human pluripotent stem cells. The foundation of this model is the quality of the first progenitors called primordial germ cells (PGCs), which in vivo are specified during the peri ...
Aslanyan, Marianna, Chen, Di, Clark, Amander, Faith, Jared, Fu, Jianping, Hou, Lei, Kellis, Manolis, Kim, Rachel, Liu, Wanlu, Sun, Na, Tao, Yu, Zheng, Yi   +11 more
core  

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

Nature Biomedical Engineering, 2018
The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been exploited for the treatment of diseases.
Bohao Liu, Benjamin W. Lee, Koki Nakanishi, Aranzazu Villasante, Rebecca L. Williamson, Jordan B. Metz, Jinho Kim, Mariko Kanai, Lynn Bi, K. Brown, G. Di Paolo, S. Homma, P. Sims, V. Topkara, G. Vunjak‐Novakovic   +14 more
semanticscholar   +1 more source

Mechanically and Chemically Defined PEG Hydrogels Improve Reproducibility in Human Cardioid Development

Advanced Healthcare Materials, EarlyView.
Synthetic matrix metalloproteinase (MMP)‐degradable polyethylene glycol (PEG)‐based hydrogels are developed to investigate the influence of mechanical and biochemical cues on cardioid development. Matrix stiffness and cell adhesion motifs significantly regulate cardioid formation, chamber morphogenesis, contractile function, and cardioid transcriptome.
Yuanhui Song, Michael Seitz, Andrew Kowalczewski, Nhu Y Mai, Era Jain, Huaxiao Yang, Zhen Ma   +6 more
wiley   +1 more source

Generation of hiPSC lines with fusion tagged thyroid hormone receptor α isoforms to study isoform-specific actions of TRα1 and TRα2

Stem Cell Research
The role of the nuclear thyroid hormone receptor TRα1 as a mediator of thyroid hormone action on target gene expression is well understood. However, the function of the TRα2 splicing isoform, which does not bind thyroid hormones, remains unexplored.
Nina Härting, Katarzyna A. Ludwik, Regina Jahn, Frank J. Kaiser, Harald Stachelscheid   +4 more
doaj  

Pluripotent Stem Cells: Current Understanding and Future Directions

Stem Cells International, 2016
Pluripotent stem cells have the ability to undergo self-renewal and to give rise to all cells of the tissues of the body. However, this definition has been recently complicated by the existence of distinct cellular states that display these features ...
Antonio Romito, Gilda Cobellis
doaj   +1 more source

Transcriptional profiling reveals fundamental differences in iPS-derived progenitors of endothelial cells (PECs) versus adult circulating EPCs [PDF]

arXiv, 2020
There are a number of different stem cell sources that have the potential to be used as therapeutics in vascular degenerative diseases. On the one hand, there are so called endothelial progenitor cells (EPCs), which are typically derived from adult blood. They carry the marker CD34, but the true nature and definition of EPCs is still controversial.
arxiv  

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

Nature Biotechnology, 2015
Kidney cells and tissues derived from human pluripotent stem cells (hPSCs) may enable organ regeneration, disease modeling and drug screening. We report an efficient, chemically defined protocol for differentiating hPSCs into multipotent nephron ...
Ryuji Morizane, A. Q. Lam, Benjamin S. Freedman, S. Kishi, M. T. Valerius, J. Bonventre   +5 more
semanticscholar   +1 more source

Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction

Advanced Healthcare Materials, EarlyView.
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi, Beatrice Auletta, Luigi Sartore, Marco La Placa, Giada Cecconi, Pietro Chiolerio, Edoardo Maghin, Silvia Angiolillo, Eugenia Carraro, Onelia Gagliano, Cecilia Laterza, Nicola Elvassore, Martina Piccoli, Anna Urciuolo   +13 more
wiley   +1 more source

Legislation governing pluripotent stem cells in South Africa

South African Journal of Bioethics and Law, 2015
One of the most exciting areas of medical research involves the use of stem cells for the treatment of patients with a variety of diseases and for tissue repair.
Michael Pepper, C Gouveia, M Slabbert
doaj   +1 more source