Results 11 to 20 of about 980,977 (401)

Epigenetic memory in induced pluripotent stem cells. [PDF]

Nature, 2010
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues.
Aryee, MJ, Cahan, P, Cunniff, KC, Daley, GQ, Doi, A, Ehrlich, LIR, Feinberg, AP, Hanna, J, Hongguang, H, Irizarry, RA, Jaenisch, R, Ji, H, Jung, N, Kim, J, Kim, K, McKinney-Freeman, S, Murakami, P, Naveiras, O, Ng, K, Orkin, SH, Seita, J, Takeuchi, A, Weissleder, R, Weissman, IL, Wen, B, Yabuuchi, A, Yoon, TJ, Zhao, R   +27 more
core   +2 more sources

Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells [PDF]

, 2013
Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic ...
Inoue-Yokoo, Tomoko, Lai, Mei I., Lim, Wai Feng, Sugiyama, Daisuke, Tan, Keai Sinn   +4 more
core   +1 more source

Pluripotent stem cells [PDF]

Transfusion Clinique et Biologique, 2009
The isolation of human embryonic stem cells (ESC) in 1998 has created the hope that stem cells will one day be used to regenerate tissues and organs, even though it is obvious that a number of hurdles will need to be overcome for such therapies to become reality.
openaire   +3 more sources

Chromatin structure of pluripotent stem cells and induced pluripotent stem cells [PDF]

Briefings in Functional Genomics, 2011
Pluripotent embryonic stem (ES) cells are specialized cells with a dynamic chromatin structure, which is intimately connected with their pluripotency and physiology. In recent years somatic cells have been reprogrammed to a pluripotent state through over-expression of a defined set of transcription factors.
Paul, Delgado-Olguín, Félix, Recillas-Targa   +1 more
openaire   +2 more sources

An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells. [PDF]

, 2013
Duchenne muscular dystrophy is a progressive and incurable neuromuscular disease caused by genetic and biochemical defects of the dystrophin-glycoprotein complex.
Borges, Luciene, Chamberlain, Jeffrey S, Darabi, Radbod, Ervasti, James M, Filareto, Antonio, Iacovino, Michelina, Kyba, Michael, Mayerhofer, Timothy, McIvor, R Scott, Parker, Sarah, Perlingeiro, Rita CR, Schaaf, Tory   +11 more
core   +2 more sources

Reconstructing aspects of human embryogenesis with pluripotent stem cells

Nature Communications, 2021
Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown.
B. Sozen, Victoria Jorgensen, Bailey A. T. Weatherbee, Sisi Chen, Meng Zhu, M. Zernicka-Goetz   +5 more
semanticscholar   +1 more source

Porcine OCT4 reporter system as a tool for monitoring pluripotency states

Journal of Animal Reproduction and Biotechnology, 2021
Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent
Seung-Hun Kim, Chang-Kyu Lee
doaj   +1 more source

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing

Non-coding RNA Research, 2017
In recent years, different studies have revealed that adult mammalian cardiomyocytes have the capacity to self-renew under homeostatic conditions and after myocardial injury.
Elena Garreta, Patricia Prado, Juan Carlos Izpisua Belmonte, Nuria Montserrat   +3 more
doaj   +1 more source

Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells [PDF]

, 2016
A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved ...
Gowran, Aoife, Nigro, Patrizia, Perrucci, Gianluca L., Pompilio, Giulio, Rasponi, Marco, Righetti, Stefano, Visone, Roberta, Zanobini, Marco   +7 more
core   +4 more sources