Stability and Hopf bifurcation in a mathematical model of pluripotent stem cell dynamics [PDF]
Nonlinear Analysis Real World Applications 6, 4 (2005) 651-670, 2009 We study a mathematical model describing the dynamics of a pluripotent stem cell population involved in the blood production process in the bone marrow. This model is a differential equation with a time delay. The delay describes the cell cycle duration and is uniformly distributed on an interval. We obtain stability conditions independent of the delay.
Mostafa Adimy +2 more
arxiv +3 more sources
Epigenetic memory in induced pluripotent stem cells. [PDF]
Nature, 2010 Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues.
Aryee, MJ +27 more
core +2 more sources
Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation [PDF]
, 2015 Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these processes is essential to the reprogramming of cells for biomedical applications, i.e., the experimental recovery of ...
Furusawa, Chikara +2 more
arxiv +5 more sources
Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells. [PDF]
PLoS ONE, 2012 Human embryonic germ cells (EGCs) provide a powerful model for identifying molecules involved in the pluripotent state when compared to their progenitors, primordial germ cells (PGCs), and other pluripotent stem cells.
Nikta Pashai +7 more
doaj +19 more sources
Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells [PDF]
Stem Cells International, 2016 A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved ...
Aoife Gowran +7 more
doaj +4 more sources
Breathing Chromatin in Pluripotent Stem Cells [PDF]
Developmental Cell, 2006 Only a few factors controlling stem cell pluripotency have been identified to date, and we do not yet fully understand how they act to maintain pluripotency and control differentiation. A report in this issue of Developmental Cell (Meshorer et al., 2006) describes a new trait of pluripotent cells: hyperdynamic or "breathing" chromatin.
Thomas P. Zwaka
openalex +4 more sources
Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors [PDF]
, 2008 Kazutoshi Takahashi +6 more
openalex +2 more sources
Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System. [PDF]
, 2017 Monitoring pluripotent stem cell behaviors (self-renewal and differentiation to specific lineages/phenotypes) is critical for a fundamental understanding of stem cell biology and their translational applications.
Horner, Christopher B +7 more
core +15 more sources
Retrotransposons in pluripotent stem cells [PDF]
Cell Regeneration, 2020 AbstractTransposable elements constitute about half of the mammalian genome, and can be divided into two classes: the class I (retrotransposons) and the class II (DNA transposons). A few hundred types of retrotransposons, which are dynamic and stage specific, have been annotated.
Junjiu Huang +3 more
openaire +4 more sources
Pluripotency of induced pluripotent stem cells [PDF]
Journal of Animal Science and Biotechnology, 2012 Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) cells.
Shaorong Gao, Lan Kang
openaire +4 more sources