Results 11 to 20 of about 201,548 (273)
ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs
STAR Protocols, 2023 Summary: CRISPR-Cas9 technology coupled with human induced pluripotent stem cells allows precise disease modeling in pluripotent cells and subsequently derived specialized cell types.
Katarzyna A. Ludwik +4 more
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Haematologica, 2015 Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells.
Isabel Dorn +16 more
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DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. [PDF]
PLoS ONE, 2012 The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability.
Li Z Luo +7 more
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Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout
Stem Cell Research, 2022 T-Box Transcription Factor 18 is a member of the T-box family, encoding TBX18 protein. As a transcriptional repressor, it related to developmental processes of a majority of tissues and organs and plays crucial part in the embryonic development of ...
Qi Xu +5 more
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Stem Cell Research, 2023 The voltage-gated potassium channel KvLQT1 encoded by KCNQ1 plays an important role in the repolarization of myocardial action potentials. KCNQ1 mutations can cause Long QT syndrome type 1 (LQT1), which is considered to be the most common causative gene ...
Hongyue Wang, Tianwei Guo, Feng Lan
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Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation [PDF]
, 2015 Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these processes is essential to the reprogramming of cells for biomedical applications, i.e., the experimental recovery of ...
arxiv +1 more source
Stem Cell Research & Therapy, 2017 Background Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling.
Elvira Parrotta +13 more
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Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. [PDF]
PLoS ONE, 2017 Oligodendrocytes myelinate axons and form myelin sheaths in the central nervous system. The development of therapies for demyelinating diseases, including multiple sclerosis and leukodystrophies, is a challenge because the pathogenic mechanisms of ...
Tomoko Yamashita +12 more
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The plant stem-cell niche and pluripotency: 15 years of an epigenetic perspective
Frontiers in Plant Science, 2022 Pluripotent stem-cells are slowly dividing cells giving rise to daughter cells that can either differentiate to new tissues and organs, or remain stem-cells.
Ralf Müller-Xing, Qian Xing
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A novel -mutated human induced pluripotent stem cell model for understanding -mutated tumors
Tumor Biology, 2020 A missense mutation of the guanine nucleotide binding protein alpha stimulating activity polypeptide 1 ( GNAS ) gene, typically Arg201Cys or Arg201His (R201H/R201C), leads to constitutive activation of the Gsα-cyclic AMP (cAMP) signaling pathway that ...
Katsuhito Watanabe +5 more
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