Results 201 to 210 of about 202,277 (222)
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Pluripotency of embryonic stem cells
Cell and Tissue Research, 2007Embryonic stem (ES) cells derived from pre-implantation embryos have the potential to differentiate into any cell type derived from the three germ layers of ectoderm (epidermal tissues and nerves), mesoderm (muscle, bone, blood), and endoderm (liver, pancreas, gastrointestinal tract, lungs), including fetal and adult cells.
Yamanaka, S +7 more
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Pluripotent stem cells in rabbits.
2021International ...
Afanassieff, Marielle +4 more
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Induced Pluripotent Stem Cells
2010Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been possible with retroviral expression of the pluripotency-associated transcription factors Oct4, Sox2, Nanog, and Lin28 as well as Klf4 and c-Myc. iPS cells hold great potential as a model for diseases from the perspective of the individual patient and as an
Holm Zaehres +3 more
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Pluripotent Stem Cells in Mice
2012Pluripotent stem cells are able to self-renew and to differentiate into all adult cell types. Many studies report data describing these cells and characterize them in molecular terms. Gene expression data of pluripotent and non-pluripotent cells from mouse were assembled.
Dirk Repsilber +4 more
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Characterization of pluripotent stem cells
Nature Protocols, 2013Characterization of pluripotent stem cells is required for the registration of stem cell lines and allows for an impartial and objective comparison of the results obtained when generating multiple lines. It is therefore crucial to establish specific, fast and reliable protocols to detect the hallmarks of pluripotency.
Leopoldo Laricchia-Robbio +7 more
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Induced pluripotent stem cells
Russian Journal of Genetics, 2009Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC).
Sergey P. Medvedev +3 more
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Cryobanking Pluripotent Stem Cells
2017Cryobanking human pluripotent stem cells (hPSCs), be they human embryonic (hESCs) or induced pluripotent stem cells (iPSCs), is essential for their use in research and cell-based therapeutics. Working and master cell banks can be generated with a desired level of quality assurance applied during cell freezing and storage. Conventional vitrification has
Tenneille Ludwig +3 more
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The development of pluripotent stem cells
Current Opinion in Genetics & Development, 2012Stem cell biology has many roots, and the current interest in the possible medical and pharmaceutical applications of pluripotent stem cells has far removed origins in the biology of a rare but peculiar type of tumor, the teratomas. The identification of their stem cells and their relationship to the early embryo paved the way, first in the mouse and ...
Paul J. Gokhale, Peter W. Andrews
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Pluripotent Stem Cell Heterogeneity
2019Pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells, show heterogeneity with respect to their pluripotency, self-renewal ability, and other traits. PSC heterogeneity may exist among cell lines, among cells within a line, and among temporal states of individual cells.
Kiyoshi Ohnuma +2 more
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Pluripotent stem cells and their niches
Stem Cell Reviews, 2006The ability of stem cells to self-renew and to replace mature cells is fundamental to ontogeny and tissue regeneration. Stem cells of the adult organism can be categorized as mono-, bi-, or multipotent, based on the number of mature cell types to which they can give rise.
M. William Lensch +3 more
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