Results 221 to 230 of about 980,977 (401)

Induced pluripotent stem cells in disease modelling and drug discovery

Nature reviews genetics, 2019
R. G. Rowe, G. Daley
semanticscholar   +1 more source

Recapitulating the human segmentation clock with pluripotent stem cells

Nature, 2020
Mitsuhiro Matsuda, Yoshihiro Yamanaka, Maya Uemura, M. Osawa, M. Saito, Ayako Nagahashi, Megumi Nishio, Long Guo, S. Ikegawa, Satoko Sakurai, Shunsuke Kihara, Thomas L. Maurissen, Michiko Nakamura, Tomoko Matsumoto, H. Yoshitomi, M. Ikeya, N. Kawakami, Takuya Yamamoto, K. Woltjen, Miki Ebisuya, J. Toguchida, C. Alev   +21 more
semanticscholar   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Correction: Generation of Human Melanocytes from Induced Pluripotent Stem Cells. [PDF]

PLoS One
Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y.   +10 more
europepmc   +1 more source

Neural differentiation from pluripotent stem cells: The role of natural and synthetic extracellular matrix

, 2014
Yan Li
openalex   +2 more sources

Generation of four severe early-onset chronic obstructive pulmonary disease (COPD) patient-derived induced pluripotent stem cell lines from peripheral blood mononuclear cells

, 2021
Engi Ahmed, Mathieu Fieldès, Joffrey Mianné, Chloé Bourguignon, A. Nasri, Isabelle Vachier, Saïd Assou, Arnaud Bourdin, John De Vos   +8 more
openalex   +1 more source

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Advanced Science, EarlyView.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Nicholas R. Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J. Adams, Mirella Dottori   +12 more
wiley   +1 more source

Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues

, 2021
Hiroaki Osada, Masahide Kawatou, Daiki Fujita, Yasuhiko Tabata, Kenji Minatoya, Jun K. Yamashita, Hidetoshi Masumoto   +6 more
openalex   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells. [PDF]

Stem Cell Reports
Sivakumar S, Wang Y, Goetsch SC, Pandit V, Wang L, Zhao H, Sundarrajan A, Armendariz D, Takeuchi C, Deng M, Nzima M, Chen WC, Dederich AE, El Hayek L, Gao T, Gogate A, Kaur K, Kim HB, McCoy MK, Niederstrasser H, Oura S, Pinzon-Arteaga CA, Sanghvi M, Schmitz DA, Yu L, Zhang Y, Zhou Q, Kraus WL, Xu L, Wu J, Posner BA, Chahrour MH, Hon GC, Munshi NV.   +33 more
europepmc   +1 more source