Results 251 to 260 of about 980,977 (401)

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

RNA Degradation in Pluripotent Stem Cells: Mechanisms, Crosstalk, and Fate Regulation. [PDF]

Cells
Jeong S, Oh M, Han J, Kim SK.
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Generation of Intestinal and Colonic Organoids Derived From Human Pluripotent Stem Cells. [PDF]

Biol Cell
Bonneau L, Brossard L, Noël T, Perreaux V, Bachir L, Khan A, Vales S, Mahe MM.   +7 more
europepmc   +1 more source

Elisa Garrido - A Progerin-inducible human induced pluripotent stem cell line to study cardiac cell aging

, 2023
Elisa Garrido
openalex   +2 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Exiting the ground state: the broad spectrum of cell fates accessible from naïve human pluripotent stem cells. [PDF]

Cell Mol Life Sci
Park KM, Yin R, Theunissen TW.
europepmc   +1 more source

The application of patient-derived induced pluripotent stem cells for modeling and treatment of Alzheimer’s disease

, 2019
Fabin Han, Chuanguo Liu, Jin Huang, Juanli Chen, Chuanfei Wei, Xiwen Geng, Yanming Liu, Dong Han, Mengpeng Li   +8 more
openalex   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Metabolic patterns predispose human pluripotent stem cells to spatial organization of cell fate. [PDF]

Front Cell Dev Biol
Deng C, Zhang Z, Xiao X, Godoy-Parejo C, Xu F, Song C, Lin H, Li Q, Fang S, Liu W, Chen G.   +10 more
europepmc   +1 more source