Results 261 to 270 of about 980,977 (401)

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Protocol for the differentiation of induced pluripotent stem cells into retinal pigment epithelial cells. [PDF]

STAR Protoc
Zorin M, Ewerling-Hähnel R, Nagel-Wolfrum K.   +2 more
europepmc   +1 more source

Generation of an induced pluripotent stem cell (iPSC) line (EXSURGi001-A) from a patient homozygous for the p.Ala165Thr mutation in the MTARC1 gene

Peter Tang, Eriselda Keshi, Silvana Wilken, Louise Wutsdorff, Julienne Mougnekabol, Johann Pratschke, Igor M. Sauer, Nils Haep   +7 more
openalex   +1 more source

One‐Step Coaxial 3D Printing of Pre‐Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing

Advanced Science, EarlyView.
A multifunctional vascular bed platform is created using coaxial 3D printing, allowing the one‐step integration of organoid microspheres with perfusable vascular structures. This strategy enables rapid and functional vascularization of organoids to support tissue repair and vascularization, providing a scalable and translationally promising approach ...
Kunrui Wang, Xiang Lan, Jianwei Chen, Yu Wu, Delong Zhu, Xiangkai Kong, Ying Hu, Qian Liu, Kun Wang, Tao Xu, Lei Zhu   +10 more
wiley   +1 more source

Induced pluripotent stem cells in the treatment of ischemic stroke. [PDF]

J Transl Int Med
Zhang Q, Song X, Ju Y, Zhao X.
europepmc   +1 more source

The role of cyclin dependent kinase 2 (Cdk2) in the proliferation and differentiation of pluripotent embryonic stem cells / Elaine B. Stead.

, 2002
Elaine Stead
openalex   +1 more source

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms

Steven Gillman
openalex   +1 more source

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

Nature, 2011
R. Lister, Mattia Pelizzola, Yasuyuki S. Kida, R. D. Hawkins, Joseph R. Nery, G. Hon, Jessica Antosiewicz-Bourget, Jessica Antosiewicz-Bourget, Ronan C. O’Malley, R. Castanon, Sarit A. Klugman, M. Downes, R. Yu, R. Stewart, R. Stewart, B. Ren, Bing-Jie Ren, J. Thomson, R. Evans, J. Ecker   +19 more
semanticscholar   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming. [PDF]

Cell Discov
Fu X, Peng F, Cai R, Mao J, Liu T, Dong Y, Cheng R, Yang Z, Chen G, Li C, Mu R, Cheng L, Wang Y, Guan J, Deng H.   +14 more
europepmc   +1 more source