Results 271 to 280 of about 962,530 (405)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm. [PDF]

PLoS Comput Biol
Mostofinejad A, Romero DA, Brinson D, Waddell TK, Karoubi G, Amon CH.   +5 more
europepmc   +1 more source

Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains

, 2007
Lioudmila V. Sharova, Alexei A. Sharov, Yulan Piao, Nabeebi Shaik, Terry Sullivan, Colin L. Stewart, Brigid L.M. Hogan, Minoru S.H. Ko   +7 more
openalex   +1 more source

Generation of cerebral organoids from human pluripotent stem cells

Nature Protocols, 2014
Madeline A. Lancaster, J. Knoblich
semanticscholar   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Synthetic thermoresponsive scaffolds for the expansion and differentiation of human pluripotent stem cells into cardiomyocytes. [PDF]

RSC Adv
Arrieta-Viana LF, Mendez-Vega J, Torres-Lugo M.   +2 more
europepmc   +1 more source

Derivation and transcriptional profiling analysis of pluripotent stem cell lines from rat blastocysts [PDF]

, 2008
Chunliang Li, Ying Yang, Junjie Gu, Yu Ma, Ying Jin   +4 more
openalex   +1 more source

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection

Advanced Science, EarlyView.
Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +10 more
wiley   +1 more source

Corrigendum for Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins. [PDF]

J Clin Invest
Mo J, Anastasaki C, Chen Z, Shipman T, Papke J, Yin K, Gutmann DH, Le LQ.   +7 more
europepmc   +1 more source

Wwp2-Mediated Ubiquitination of the RNA Polymerase II Large Subunit in Mouse Embryonic Pluripotent Stem Cells

, 2007
Hui Li, Zhihong Zhang, Beibei Wang, Junmei Zhang, Yingming Zhao, Ying Jin   +5 more
openalex   +1 more source