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Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cells. [PDF]
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Deciphering reprogramming efficiency in human induced pluripotent stem cells: insights from the generation of 150 cell lines. [PDF]
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Chemical reprogramming of human somatic cells to pluripotent stem cells
Nature, 2022Jingyang Guan +25 more
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Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming.
Cell Stem Cell, 2023We recently demonstrated the chemical reprogramming of human somatic cells to pluripotent stem cells (hCiPSCs), which provides a robust approach for cell fate manipulation.
Shi Liuyang +14 more
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Induced pluripotent stem cells
Russian Journal of Genetics, 2009Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC).
A I, Shevchenko +3 more
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Cryobanking Pluripotent Stem Cells
2017Cryobanking human pluripotent stem cells (hPSCs), be they human embryonic (hESCs) or induced pluripotent stem cells (iPSCs), is essential for their use in research and cell-based therapeutics. Working and master cell banks can be generated with a desired level of quality assurance applied during cell freezing and storage. Conventional vitrification has
Crook, Jeremy Micah +2 more
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Pluripotent Stem Cell Heterogeneity
2019Pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells, show heterogeneity with respect to their pluripotency, self-renewal ability, and other traits. PSC heterogeneity may exist among cell lines, among cells within a line, and among temporal states of individual cells.
Yohei, Hayashi +2 more
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Induced Pluripotent Stem Cells
2010Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been possible with retroviral expression of the pluripotency-associated transcription factors Oct4, Sox2, Nanog, and Lin28 as well as Klf4 and c-Myc. iPS cells hold great potential as a model for diseases from the perspective of the individual patient and as an
Zaehres, Holm +2 more
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