Results 21 to 30 of about 959,542 (406)
Reconstructing aspects of human embryogenesis with pluripotent stem cells
Nature Communications, 2021 Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown.
B. Sozen +5 more
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Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing
Non-coding RNA Research, 2017 In recent years, different studies have revealed that adult mammalian cardiomyocytes have the capacity to self-renew under homeostatic conditions and after myocardial injury.
Elena Garreta +3 more
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Pluripotency of Induced Pluripotent Stem Cells
Genomics, Proteomics & Bioinformatics, 2013 Abstract Induced pluripotent stem (iPS) cells can be generated by forced expression of four pluripotency factors in somatic cells. This has received much attention in recent years since it may offer us a promising donor cell source for cell transplantation therapy. There has been great progress in iPS cell research in the past few years.
Chunjing Feng, Yundan Jia, Xiaoyang Zhao
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miRNA in Pluripotent Stem Cells [PDF]
Regenerative Medicine, 2010 Embryonic stem cells and induced pluripotent stem cells are characterized by their ability to self-renew and differentiate into any cell type. The molecular mechanism behind this process is a complex interplay between the transcriptional factors with epigenetic regulators and signaling pathways.
Ronald P. Hart +2 more
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Improving single-cell cloning workflow for gene editing in human pluripotent stem cells [PDF]
, 2018 The availability of human pluripotent stem cells (hPSCs) and progress in genome engineering technology have altered the way we approach scientific research and drug development screens.
Chen, Yi-Hsien, Pruett-Miller, Shondra M
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Absence of Rybp Compromises Neural Differentiation of Embryonic Stem Cells
Stem Cells International, 2016 Rybp (Ring1 and Yy1 Binding Protein) is a transcriptional regulator and member of the noncanonical polycomb repressive complex 1 with essential role in early embryonic development.
Gergo Kovacs +2 more
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Frontiers in Cell and Developmental Biology, 2022 The technique of induced pluripotent stem cells has significant application value in breeding and preserving the genetic integrity of fish species. However, it is still unclear whether the chemically induced pluripotent stem cells can be induced from non-
Wenting Xu +21 more
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Breathing Chromatin in Pluripotent Stem Cells [PDF]
Developmental Cell, 2006 Only a few factors controlling stem cell pluripotency have been identified to date, and we do not yet fully understand how they act to maintain pluripotency and control differentiation. A report in this issue of Developmental Cell (Meshorer et al., 2006) describes a new trait of pluripotent cells: hyperdynamic or "breathing" chromatin.
Thomas P. Zwaka
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Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies
Neural Regeneration Research, 2022 Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement therapies. Pluripotent stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected ...
Ignacio Rodriguez-Polo, Rüdiger Behr
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Pluripotent stem cell lines [PDF]
Genes & Development, 2008 The derivation of human embryonic stem cells 10 years ago ignited an explosion of public interest in stem cells, yet this achievement depended on prior decades of research on mouse embryonic carcinoma cells and embryonic stem cells. In turn, the recent derivation of mouse and human induced pluripotent stem cells depended on the prior studies on mouse ...
James A. Thomson, Junying Yu
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